An address to young research workers: Inconsequences and blindness to the facts and unpublished observations.

Abstract:

:The critical remembrance of my research activity displays aspects of inconsequence and mental rigidity. Particular probative examples are called to mind. Unpublished observations concerning immortalized dental cells are summarized. As a consequence, if I could start again, I would improve several aspects of my behavior and attitude of mind.

journal_name

Connect Tissue Res

authors

Ruch JV

doi

10.1080/03008200290001195

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

80-6

issue

2-3

eissn

0300-8207

issn

1607-8438

journal_volume

43

pub_type

  • Downregulation of decorin and transforming growth factor-beta1 by decorin gene suppression in tendinocytes.

    abstract::Scars formed after tendonitis result in altered tissue mechanical properties after injury. The interaction of collagen molecules with decorin affects collagen fibrogenesis, and scar tissue is fragile as a consequence of a large amount of decorin in the scar. We hypothesized that scar formation could be prevented by co...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008200590935510

    authors: Hosaka Y,Kirisawa R,Mafune N,Takehana K

    更新日期:2005-01-01 00:00:00

  • The physical properties of elastic fibers and elastolysis.

    abstract::The effects of two forms of elastase on the Young's Modulus of elastic tissue have been studied. The monomeric, calcium poor form of the enzyme lowers the value of the Young's Modulus before an appreciable amount of protein is taken into solution. The polymeric, calcium rich enzyme on the other hand degrades the prote...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207609152217

    authors: Hall DA

    更新日期:1976-01-01 00:00:00

  • Lipids closely associated with bone morphogenetic protein (BMP)--and induced heterotopic bone formation. With preliminary observations of deficiencies in lipid and osteoinduction in lathyrism in rats.

    abstract::An extensive literature on bone morphogenetic protein (BMP) induced generation and regeneration shows general agreement about one observation. The incidence and quantity of bone were greatest when BMP was delivered with a carrier of various biologic and non biologic polymers. In the present research, neutral lipids ei...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209709160210

    authors: Urist MR,Behnam K,Kerendi F,Raskin K,Nuygen TD,Shamie AN,Malinin TI

    更新日期:1997-01-01 00:00:00

  • Electron imaging and diffraction study of individual crystals of bone, mineralized tendon and synthetic carbonate apatite.

    abstract::A transmission electron microscope study of carbonate apatite crystals isolated from bone and mineralizing tendon, as well as those produced synthetically under approximated-physiological conditions, shows that they are thin irregular shaped plates. Electron diffraction patterns of individual crystals confirm that the...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209109029158

    authors: Moradian-Oldak J,Weiner S,Addadi L,Landis WJ,Traub W

    更新日期:1991-01-01 00:00:00

  • Oriented fibrillogenesis of collagen in vitro by ordered convection.

    abstract::Oriented fibers, arising from the self assembly of collagen, may be produced from in vitro fibrillogenesis of soluble collagen with gradients of fibrillogenic potential. These gradients may be introduced by either concentration gradients of pronase-treated collagen or of arginine which, in turn, create concentration g...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208808992792

    authors: Ghosh S,Comper WD

    更新日期:1988-01-01 00:00:00

  • Roles of large aggregating proteoglycans in human intervertebral disc degeneration.

    abstract::Degeneration of the intervertebral discs, a natural progression of the aging process, is strongly implicated as a cause of low back pain. Aggrecan is the major structural proteoglycan in the extracellular matrix of the intervertebral disc. It is large, possessing numerous glycosaminoglycan chains and the ability to fo...

    journal_title:Connective tissue research

    pub_type: 杂志文章,评审

    doi:10.1080/03008207.2018.1499731

    authors: Wei Q,Zhang X,Zhou C,Ren Q,Zhang Y

    更新日期:2019-05-01 00:00:00

  • Association of the C-propeptide of type II collagen with mineralization of embryonic chick long bone and sternal development.

    abstract::Several proteins may play a role in bone formation. The C-propeptide of type II collagen is intimately associated with endochondral bone formation in bovine growth plate. We have used an antibody against this peptide to determine its immunofluorescent distribution in early stages of embryonic chick limb development wi...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208909002417

    authors: Kujawa MJ,Weitzhandler M,Poole AR,Rosenberg L,Caplan AI

    更新日期:1989-01-01 00:00:00

  • Partial characterization of collagenous and noncollagenous basement membrane proteins synthesized by the 14.5-day rat embryo parietal yolk sac in vitro.

    abstract::Parietal yolk sacs isolated from 14.5-day rat embryos and incubated in vitro with either [14C]proline, [3H]mannose or 3H-labeled amino acid mixture synthesized and secreted basement membrane collagenous and noncollagenous glycoprotein components with relative molecular weights of 350,000 (350K), 220,000 (220K), 185,00...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208209008056

    authors: Clark CC,Kefalides NA

    更新日期:1982-01-01 00:00:00

  • Stem cell-based small-diameter vascular grafts in dynamic culture.

    abstract::Purpose: Transplantation of autologous and/or allogeneic blood vessels is the most convenient treatment for vascular diseases. With regard to extensive need for blood vessels, developments in vascular tissue engineering are contributing greatly. In this study, our aim is to create intact small-diameter tubular vascula...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008207.2019.1651848

    authors: Çelebi-Saltik B,Öteyaka MÖ,Gökçinar-Yagci B

    更新日期:2021-03-01 00:00:00

  • Effect of temperature on the metabolism of proteoglycans in explants of bovine articular cartilage.

    abstract::The turnover of proteoglycans in bovine articular cartilage was determined in explant cultures, maintained at 32 degrees C or 37 degrees C. Both the rate of proteoglycan synthesis and the release of newly synthesized proteoglycans were decreased in cultures incubated at 32 degrees C compared to 37 degrees C. At both t...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209109152166

    authors: Brand HS,De Koning MH,van Kampen GP,Van der Korst JK

    更新日期:1991-01-01 00:00:00

  • Effects of pulsed electromagnetic fields on the mRNA expression of RANK and CAII in ovariectomized rat osteoclast-like cell.

    abstract::This study was designed to determine the effects of pulsed electromagnetic fields (PEMF) on the mRNA expression of the receptor activator of NF-kappa-B (RANK) and carbonic anhydrase II (CA II) in ovariectomized rat osteoclast-like cells. Marrow cells were harvested from femora and tibiae of rats, from which the ovarie...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008200902855917

    authors: Chen J,He HC,Xia QJ,Huang LQ,Hu YJ,He CQ

    更新日期:2010-01-01 00:00:00

  • Stimulation of small proteoglycan synthesis by the hyaluronan synthesis inhibitor 4-methylumbelliferone in human skin fibroblasts.

    abstract::Human skin fibroblasts cultured with 4-methylumbelliferone (MU), a hyaluronan synthesis inhibitor, produce a hyaluronan-deficient extracellular matrix (See [9]). Our present study investigated the effects of MU on proteoglycan, which is the other main component of the extracellular matrix, and interacts with hyalurona...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008200802684615

    authors: Funahashi M,Nakamura T,Kakizaki I,Mizunuma H,Endo M

    更新日期:2009-01-01 00:00:00

  • Distributions of types I, II and III collagen by region in the human supraspinatus tendon.

    abstract::The mechanical properties of the human supraspinatus tendon (SST) are highly heterogeneous and may reflect an important adaptive response to its complex, multiaxial loading environment. However, these functional properties are associated with a location-dependent structure and composition that have not been fully eluc...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207.2013.847096

    authors: Buckley MR,Evans EB,Matuszewski PE,Chen YL,Satchel LN,Elliott DM,Soslowsky LJ,Dodge GR

    更新日期:2013-01-01 00:00:00

  • Influence of substrate nature and immobilization of implanted dentin matrix components during induction of reparative dentinogenesis.

    abstract::The biological effects of isolated soluble dentin extracellular matrix components on the induction of reparative dentinogenesis in exposed cavities in ferret canine teeth have been shown to be blocked by immobilizing the extracellular matrix components on nitrocellulose or Millipore membranes during implantation. This...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209509013736

    authors: Smith AJ,Tobias RS,Cassidy N,Bégue-Kirn C,Ruch JV,Lesot H

    更新日期:1995-01-01 00:00:00

  • Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference.

    abstract::Multiple hereditary exostoses (MHE) is an autosomal dominant disorder that affects about 1 in 50,000 children worldwide. MHE, also known as hereditary multiple exostoses (HME) or multiple osteochondromas (MO), is characterized by cartilage-capped outgrowths called osteochondromas that develop adjacent to the growth pl...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008207.2017.1394295

    authors: Phan AQ,Pacifici M,Esko JD

    更新日期:2018-01-01 00:00:00

  • The effect of halides (NaCl and NaI) on in vitro pancreatic elastase activity.

    abstract::The effect of I- and C1- on the enzymatic degradation of elastin pancreatic elastase has been studied. At low halide concentrations both ions show a marked stimulation of elastolysis, I- being significantly more effective than Cl-. Kinetic plots of enzyme activity indicate that anions enhance the susceptibility of the...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207809152616

    authors: Winkler RH

    更新日期:1978-01-01 00:00:00

  • Expression of the elastin promoter in novel tissue sites in transgenic mouse embryos.

    abstract::We have previously shown in a transgenic mouse line, in which 5.2 kb of the elastin promoter was linked to the reporter enzyme chloramphenicol acetyltransferase (CAT), that the highest levels of expression were found in embryonic lungs and aorta, while lower levels were detected in other elastin-containing tissues. Fu...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209909029111

    authors: Lakkakorpi J,Li K,Decker S,Korkeela E,Piddington R,Abrams W,Bashir M,Uitto J,Rosenbloom J

    更新日期:1999-01-01 00:00:00

  • Biochemical evaluation of organ cultures from primate flexor tendons.

    abstract::Recently our laboratory has reported, in a lacerated flexor tendon model, that the "early turnover" phase of the repair process extends for a longer period of time in vivo than previously documented. The extensive turnover of the collagenous matrix was consistent with the presence of collagenolytic activity in repairi...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208909103903

    authors: Russell JE,Manske PR

    更新日期:1989-01-01 00:00:00

  • Biochemical characterization of collagen in alveolar mucosa and attached gingiva of pig.

    abstract::Alveolar mucosa and attached gingiva are two continuous but functionally distinct connective tissues covering alveolar bone of the jaw. In this study, the major matrix component of these tissues, collagen, was biochemically characterized and compared. The tissues were obtained from mature pigs and analyzed for collage...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008200601143508

    authors: Katafuchi M,Matsuura T,Atsawasuwan P,Sato H,Yamauchi M

    更新日期:2007-01-01 00:00:00

  • Nitrite-induced cross-linking alters remodeling and mechanical properties of collagenous engineered tissues.

    abstract::Cumulative damage to long-lived connective tissue proteins play a key role in the development of age-related human diseases such as cardiovascular stiffening and age-related macular degeneration. The processes that result in the accumulation of increasingly insoluble, undigestible damaged collagen are only partially k...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008200600721569

    authors: Paik DC,Saito LY,Sugirtharaj DD,Holmes JW

    更新日期:2006-01-01 00:00:00

  • Water content of equine articular cartilage: effects of enzymatic degradation and "artificial fibrillation".

    abstract::A method is described for accurate and reproducible determination of wet and dry weights of small articular cartilage samples. The water content of the articular cartilage samples before and after treatment with selective degradative enzymes and "artificial fibrillation" was determined. It was found that the water con...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208209160266

    authors: Simon WH,Wohl DL

    更新日期:1982-01-01 00:00:00

  • Molecular and structural mapping of collagen fibril interactions.

    abstract::The fibrous collagens form the structural basis of all mammalian connective tissues, including the vasculature, dermis, bones, tendons, cartilage, and those tissues that support organs such as the heart, kidneys, liver, and lungs. The helical structure of collagen has been extensively studied but in addition to its he...

    journal_title:Connective tissue research

    pub_type: 杂志文章,评审

    doi:10.3109/03008207.2010.511353

    authors: Orgel JP,San Antonio JD,Antipova O

    更新日期:2011-02-01 00:00:00

  • TGF beta-1 downregulates DMP-1 and DSPP in odontoblasts.

    abstract::Transforming growth factor beta-1 (TGF beta-1) is a multifunctional growth factor that is expressed in numerous cell types. It has been shown to induce secretion of dentin extracellular matrix components associated with primary dentinogenesis and to play a role in tertiary or reparative dentinogenesis. In this study, ...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008200290000565

    authors: Unterbrink A,O'Sullivan M,Chen S,MacDougall M

    更新日期:2002-01-01 00:00:00

  • The effects of aging upon the connective tissues of the periodontal ligament.

    abstract::The ultrastructural features of the cells and of the oxytalan fibers within the periodontal ligaments of aged rats (2 year old) were quantified and compared with data for tissues obtained from younger animals (8 week old). Sections of the mid-root regions of the mandibular first molars were prepared for examination by...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209509016978

    authors: Moxham BJ,Evans IL

    更新日期:1995-01-01 00:00:00

  • Helix structure of ribbon-like crystals in bovine enamel.

    abstract::In the early mineralized enamel crystals, ribbon-like crystals appear near the ameloblasts. Some ribbon-like crystals showed helical or spiral structure within restricted environment during the preparation of embryonic bovine specimens for electron microscope. These specimens did not suffer from the cutting damages no...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209809017027

    authors: Suzuki K,Sakae T,Kozawa Y

    更新日期:1998-01-01 00:00:00

  • X-ray diffraction and scanning electron microscopy of bovine media aortic wall.

    abstract::Scanning electron microscopy and high angle X-ray diffraction were used to define the relationship between collagen and elastin of bovine aortic wall. The diffraction pattern shows on one hand that the broad rings at 4.5 A and 9 A, due to elastin, do not orient on stretching and on the other hand, that the collagen ri...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207709152610

    authors: Bigi A,Ripamonti A,Roveri N

    更新日期:1977-01-01 00:00:00

  • Expression analysis of angiogenic growth factors and biological axis CXCL12/CXCR4 axis in idiopathic pulmonary fibrosis.

    abstract::Idiopathic pulmonary fibrosis (IPF) is associated with aberrant repair, persistence of collagen deposition, and the development of vascular remodeling. However, the role of angiogenesis in the pathogenesis of IPF is still undetermined. The aim of this study was to evaluate the combined mRNA expression of vascular endo...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008200903056150

    authors: Antoniou KM,Soufla G,Lymbouridou R,Economidou F,Lasithiotaki I,Manousakis M,Drositis I,Spandidos DA,Siafakas NM

    更新日期:2010-01-01 00:00:00

  • The catabolic fate of hyaluronic acid.

    abstract::Part of the hyaluronic acid (HA) synthesized in peripheral tissues enters the blood circulation through the lymph. It is rapidly taken up by the endothelial cells in the liver (half-life in blood is 2.5-5.5 minutes) and degraded. Pure primary cultures of liver endothelial cells were obtained by a newly developed techn...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208609001971

    authors: Laurent TC,Dahl IM,Dahl LB,Engström-Laurent A,Eriksson S,Fraser JR,Granath KA,Laurent C,Laurent UB,Lilja K

    更新日期:1986-01-01 00:00:00

  • Changes in vascular extracellular matrix accumulation reflect phenotypic differences between the arterial wall of pigeons resistant and susceptible to the development of spontaneous atherosclerosis.

    abstract::White Carneau pigeons have previously been shown to be genetically susceptible to the development of spontaneous atherogenesis. The severity of development of atheromatous lesions is considerably greater than a more resistant breed of Show Racer pigeons. Analysis of levels of total hydroxyproline and isodesmosine in t...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209009009813

    authors: Park HS,Kniep AC,Smith SC,Robie SM,Smith EC,Yu SY,Mackenzie JW,Scott GE,Boyd CD

    更新日期:1990-01-01 00:00:00

  • Is low molecular weight hyaluronan an early indicator of disease in avian systemic sclerosis?

    abstract:AIM OF THE STUDY:To further elucidate the pathogenesis of systemic sclerosis (SSc) an experimental avian model was used. The University of California at Davis line 200 (UCD-200) chickens spontaneously develop a SSc-like disease that has most features of human SSc with vascular effects, inflammation, autoimmunity, and f...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008207.2016.1182997

    authors: Kerje S,Hellman U,Do L,Larsson G,Kämpe O,Engström-Laurent A,Lindqvist U

    更新日期:2016-09-01 00:00:00