Abstract:
:Hyperhomocysteinemia causes connective tissue pathology. Several theories on the mechanism of homocysteine toxicity in connective tissue are reviewed briefly. A possible new mechanism was revealed recently in the discovery of a reaction in which homocysteine thiolactone is converted to mercaptopropionaldehyde. The reaction is the Strecker degradation of amino acids in which ninhydrin is replaced by the structurally similar dehydroascorbic acid. The reaction may occur in vivo and may be pathogenic to connective tissue in four ways: (1) the reaction may deplete ascorbic acid that is required for collagen synthesis, (2) the mercaptoaldehyde product may interfere with collagen synthesis, (3) the mercaptoaldehyde may cause abnormal cross-linking of collagen molecules, and (4) the mercaptoaldehyde may attach to collagen molecules rendering them antigenic and triggering an autoimmune response.
journal_name
Connect Tissue Resjournal_title
Connective tissue researchauthors
Toohey JIdoi
10.1080/03008200801913742subject
Has Abstractpub_date
2008-01-01 00:00:00pages
57-61issue
2eissn
0300-8207issn
1607-8438pii
791846471journal_volume
49pub_type
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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journal_title:Connective tissue research
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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