Common gene variants interactions related to uric acid transport are associated with knee osteoarthritis susceptibility.

abstract：:Conditions were established to stimulate human gingival fibroblast explant cultures to synthesize milligram quantities of the metalloproteinase proenzymes, prostromelysin and procollagenase. To stimulate enzyme production, cells were treated with 1 nM recombinant human IL-1 beta for approximately 7 days under serum fr...

journal_title：Connective tissue research

authors： Lark MW,Walakovits LA,Shah TK,Vanmiddlesworth J,Cameron PM,Lin TY

更新日期：1990-01-01 00:00:00

abstract：AIM OF THE STUDY:Tendons are exposed to mechanical stress constantly during movements and thus they are frequently subjected to injuries. Rotator cuff tears are common musculoskeletal disorders, mainly involving the supraspinatus tendon. The characterization of the tenocytes derived from this tendon and the comparison ...

journal_title：Connective tissue research

authors： Viganò M,Lugano G,Orfei CP,Menon A,Ragni E,Colombini A,de Luca P,Talò G,Randelli PS,de Girolamo L

更新日期：2020-09-14 00:00:00

abstract：:The in-vitro fluoride treatment technique has been introduced to investigate the composite behavior of bone tissue. Bone tissue with different mechanical properties can be obtained by varying the concentration, pH and immersion time in fluoride ion solutions. The chemical and physical changes in intact pieces of bone ...

journal_title：Connective tissue research

authors： Kotha SP,DePaula CA,Koike K,Pan Y,Ohno M,Abjornson C,Rangarajan S,Guzelsu N

更新日期：2002-01-01 00:00:00

abstract：:Ultrasound is a therapeutic agent commonly used to treat sports-related tendinopathy. Tendon healing requires tendon cells migration to the repair site, followed by the proliferation and synthesis of extracellular matrix. This study was designed to determine the effect of ultrasound on migration of tendon cells intrin...

journal_title：Connective tissue research

authors： Tsai WC,Chen JY,Pang JH,Hsu CC,Lin MS,Chieh LW

更新日期：2008-01-01 00:00:00

abstract：:Effects of applied hydrostatic pressure on transmembrane potentials were investigated in sheep articular chondrocytes and human skin fibroblasts in non-confluent monolayer cultures. Resting potentials in chondrocytes (about -12 mv) and in fibroblasts (about -15 mV) were increased and decreased respectively by over 40%...

journal_title：Connective tissue research

authors： Wright MO,Stockwell RA,Nuki G

更新日期：1992-01-01 00:00:00

abstract：:Purpose: The osteocyte is considered the major mechanosensor in bone, capable of detecting forces at a cellular level to coordinate bone formation and resorption. The pathology of age-related bone loss, a hallmark of osteoporosis, is attributed in part to impaired osteocyte mechanosensing. However, real-time evidence ...

journal_title：Connective tissue research

authors： Morrell AE,Robinson ST,Silva MJ,Guo XE

更新日期：2020-05-01 00:00:00

abstract：:Bone sialoprotein (BSP) expression is restricted to cells associated with the mineralization of bones and teeth. We previously identified a homeodomain binding element in a 2.5 kb fragment of the murine Bsp promoter that is required for osteoblast-selective expression in cell culture. To examine the role of this eleme...

journal_title：Connective tissue research

authors： Gopalakrishnan R,Thomas PE,Benson MD,Wang D,Franceschi RT

更新日期：2003-01-01 00:00:00

abstract：:Purpose: In experimental models of equine joint-injury and osteoarthritis synovial fluid (SF) composition (proteoglycan-4, hyaluronan) can vary, along with changes to SF mechanical function (lubrication, viscosity). The study hypotheses were a) clinical equine joint-injury and disease results in altered SF composition...

journal_title：Connective tissue research

authors： Matheson A,Regmi SC,Martin-Alarcon L,Jay GD,Scott WM,Schmidt TA

更新日期：2020-04-20 00:00:00

abstract：:A transmission electron microscope study of carbonate apatite crystals isolated from bone and mineralizing tendon, as well as those produced synthetically under approximated-physiological conditions, shows that they are thin irregular shaped plates. Electron diffraction patterns of individual crystals confirm that the...

journal_title：Connective tissue research

authors： Moradian-Oldak J,Weiner S,Addadi L,Landis WJ,Traub W

更新日期：1991-01-01 00:00:00

abstract：:This study aims to elucidate the feasible geometry of the scaffolds in bone and periodontal tissue engineering. Several biomaterials with different geometries are compared in terms of their patterns of ectopic BMP-induced chondrogenesis and osteogenesis. The materials include a honeycomb-shaped hydroxyapatite (HCHAP) ...

journal_title：Connective tissue research

authors： Kuboki Y,Jin Q,Kikuchi M,Mamood J,Takita H

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Excessive apoptosis plays an important role in the progression of intervertebral disc degeneration. However, the effect of autophagy, another type of programmed cell death, on the pathogenesis of disc degeneration is still unclear. Macroautophagy and chaperone-mediated autophagy (CMA) change and intervertebra...

journal_title：Connective tissue research

authors： Ye W,Xu K,Huang D,Liang A,Peng Y,Zhu W,Li C

更新日期：2011-01-01 00:00:00

abstract：:Purpose/Aim: Elevated serum phosphate is one of the major factors contributing to vascular calcification. Studies suggested that extracellular vesicles released from vascular smooth muscle cells significantly contribute to the initiation and progression of this pathology. Recently, we have demonstrated that elevated p...

journal_title：Connective tissue research

authors： Chaudhary SC,Khalid S,Smethurst V,Monier D,Mobley J,Huet A,Conway JF,Napierala D

更新日期：2018-12-01 00:00:00

abstract：:Changes in the structure and organization of collagen fibrils were recently described in the skin of aspartylglycosaminuria patients. The skin of the patients contained a normal amount and distribution of glycosaminoglycans, but the dermatan sulfate of aspartylglycosaminuria skin was more sensitive to chondroitinase A...

journal_title：Connective tissue research

authors： Näntö-Salonen K,Larjava H,Säämanen AM,Heino J,Penttinen R,Pelliniemi LJ,Tammi M

更新日期：1987-01-01 00:00:00

abstract：:Abnormal polyanion metabolism in cultured fibroblasts from patients with pseudoxanthoma elasticum (PXE) was studied by incubating normal and PXE fibroblasts in culture medium containing 35SO4 for 96 hr and measuring differences in secreted 35SO4-labelled proteoglycans (35S-PG). PXE medium contained less high molecular...

journal_title：Connective tissue research

authors： Gordon SG,Overland M,Foley J

更新日期：1978-01-01 00:00:00

abstract：OVERVIEW:Periostin (POSTN) is critical to bone and dental tissue morphogenesis, postnatal development, and maintenance; however, its roles in tissue repair and regeneration mediated by human periodontal ligament mesenchymal stem cells (PDLSCs) remain unclear. The present study was designed to evaluate the effects of PO...

journal_title：Connective tissue research

authors： Wu Z,Dai W,Wang P,Zhang X,Tang Y,Liu L,Wang Q,Li M,Tang C

更新日期：2018-03-01 00:00:00

abstract：:Two overlapping clones encompassing 8.5 kb of the human elastin gene were isolated from two genomic libraries constructed by partial digestion with either HaeIII/AluI or Sau3A and contained in lambda Charon 4A or EMBL3, respectively. The 6 kb of DNA comprising the most 3' portion of the gene were sequenced demonstrati...

journal_title：Connective tissue research

authors： Indik Z,Yoon K,Morrow SD,Cicila G,Rosenbloom J,Rosenbloom J,Ornstein-Goldstein N

更新日期：1987-01-01 00:00:00

abstract：:To investigate the source of bone brittleness in the disease osteogenesis imperfecta (OI), biomechanical properties have been measured in the femurs from a homozygous (oim/oim) mutant mouse model of OI, its heterozygous littermates, and wild-type animals. The novel technique of ultrasound critical-angle reflectometry ...

journal_title：Connective tissue research

authors： Mehta SS,Antich PP,Landis WJ

更新日期：1999-01-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) (4F2 and 7E12) were prepared against heparan sulfate proteoglycan (HSPG) isolated from bovine glomeruli. Enzyme linked immunosorbent assays (ELISA) and immunoblotting demonstrated that the mABs reacted with HSPG. Indirect immunofluorescence (IF) showed that the mAbs stained renal basement ...

journal_title：Connective tissue research

authors： Kemeny E,Fillit HM,Damle S,Mahabir R,Kefalides NA,Gregory JD,Antonovych T,Sabnis S,Zabriskie JB

更新日期：1988-01-01 00:00:00

abstract：:Purpose: Non-pathological child cortical bone (NPCCB) studies can provide clinicians with vital information and insights. However, assessing the anisotropic elastic properties of NPCCB remains a challenge for the biomechanical engineering community. For the first time, this paper provides elastic moduli values for NPC...

journal_title：Connective tissue research

authors： Semaan M,Karam E,Baron C,Pithioux M

更新日期：2019-07-01 00:00:00

abstract：:Primary chondrocytes cultured in agarose can escape the gel, accumulate at the interface between agarose and the culture medium, and form an outgrowing tissue. These outgrowths can appear as voluminous cartilage-like nodules that have never been previously investigated. In the present study, bovine articular chondrocy...

journal_title：Connective tissue research

authors： Tran-Khanh N,Chevrier A,Lascau-Coman V,Hoemann CD,Buschmann MD

更新日期：2010-06-01 00:00:00

abstract：:Gene expression of osteopontin (OPN) has been investigated in mice by application of laser capture microdissection (LCM) and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. LCM permits individual cells to be isolated ("captured") from tissue sections for molecular analyses. In this study, chondrocyt...

journal_title：Connective tissue research

authors： Landis WJ,Jacquet R,Hillyer J,Zhang J

更新日期：2003-01-01 00:00:00

abstract：:The small leucine-rich repeat proteoglycans (SLRPs) constitute a group of structurally and functionally related molecules that participate in the organization of the extracellular matrix ECM and have important effects on cell behavior. Osteosarcomas are heterogeneous bone tumors whose common characteristic is the prod...

journal_title：Connective tissue research

authors： Nikitovic D,Berdiaki K,Chalkiadaki G,Karamanos N,Tzanakakis G

更新日期：2008-01-01 00:00:00

abstract：:Aseptic loosening remains the primary cause of failure in total joint arthroplasty. Implant-derived particles are thought to be a main cause of osteolysis that leads to the failure. Substance P (SP) immunoreactive nerve fibers have been detected in the periprosthetic membrane of aseptic loose hip prostheses. We isolat...

journal_title：Connective tissue research

authors： Qian Y,Zhang XL,Zeng BF,Jiang Y,Shen H,Wang Q

更新日期：2013-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are members of the Metzincin family of proteases responsible for degrading the extracellular matrix (ECM). In early studies, MMP degradation of the sub-epithelial basement membrane was thought to be tumor cell autonomous and contribute to the invasive behavior of malignant cells. It is...

journal_title：Connective tissue research

authors： Stetler-Stevenson WG,Gavil NV

更新日期：2014-01-01 00:00:00

abstract：:Size measurements of dispersed rat bone crystals show that with age a greater proportion exceeds 400 A in length. The surface fractures of more heavily mineralized bones tend to be smooth and stepped, whereas those of less mineralized bones are fibrous. These observations combined with information reported elsewhere o...

journal_title：Connective tissue research

authors： Weiner S,Traub W

更新日期：1989-01-01 00:00:00

abstract：:The interaction of elastin and microfibrils in elastogenesis in vitro was investigated with electron microscopy and immunohistochemistry. Fetal human pulmonary fibroblasts were cultured with or without beta-aminopropionitrile (BAPN). One week after seeding, the extracellular microfibrils were loosely arranged without ...

journal_title：Connective tissue research

authors： Fukuda Y,Nakazawa N,Yamanaka N

更新日期：1993-01-01 00:00:00

abstract：:This study examines the similarities and differences in the noncollagenous domain (NC1) of type IV collagen from human glomerular basement membrane (hGBM), alveolar basement membrane (hABM), and placenta (hPBM). Following collagenase digestion, NC1 domain was isolated on Bio-Gel A-0.5m or by cation exchange chromatogr...

journal_title：Connective tissue research

authors： Shen GQ,Butkowski R,Cheng T,Wieslander J,Katz A,Cass J,Fish AJ

更新日期：1990-01-01 00:00:00

abstract：UNLABELLED:PURPOSE/AIMS OF THE STUDY: Bone's hierarchical structure can be visualized using a variety of methods. Many techniques, such as light and electron microscopy generate two-dimensional (2D) images, while micro-computed tomography (µCT) allows a direct representation of the three-dimensional (3D) structure. In ...

journal_title：Connective tissue research

authors： Hoerth RM,Baum D,Knötel D,Prohaska S,Willie BM,Duda GN,Hege HC,Fratzl P,Wagermaier W

更新日期：2015-04-01 00:00:00

abstract：:Osteogenesis imperfecta is a congenital disease commonly characterized by brittle bones and caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the body. The oim model has a natural collagen mutation, converting its heterotrimeric structure (two α1 and one α2 chains)...

journal_title：Connective tissue research

authors： Bart ZR,Hammond MA,Wallace JM

更新日期：2014-08-01 00:00:00

abstract：:Positive effects on the tensile characteristics of swine digital extensors were found following twelve months of exercise training. Compared to sedentary controls, the tendons from the exercised animals became stronger as a material and exhibited hypertrophy. These biomechanical results were supported by biochemical a...

journal_title：Connective tissue research

authors： Woo SL,Ritter MA,Amiel D,Sanders TM,Gomez MA,Kuei SC,Garfin SR,Akeson WH

更新日期：1980-01-01 00:00:00