Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein.

Abstract:

:Escherichia coli acetyl coenzyme A carboxylase (ACC), the first enzyme of the fatty acid biosynthetic pathway, is inhibited by acylated derivatives of acyl carrier protein (ACP). ACP lacking an acyl moiety does not inhibit ACC. Acylated derivatives of ACP having chain lengths of 6 to 20 carbon atoms were similarly inhibitory at physiologically relevant concentrations. The observed feedback inhibition was specific to the protein moiety, as shown by the inability of the palmitoyl thioester of spinach ACP I to inhibit ACC.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Davis MS,Cronan JE Jr

doi

10.1128/JB.183.4.1499-1503.2001

keywords:

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

1499-503

issue

4

eissn

0021-9193

issn

1098-5530

journal_volume

183

pub_type

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