The Helicobacter pylori CrdRS two-component regulation system (HP1364/HP1365) is required for copper-mediated induction of the copper resistance determinant CrdA.

Abstract:

:Here we describe that the Helicobacter pylori sensor kinase produced by HP1364 and the response regulator produced by HP1365 and designated CrdS and CrdR, respectively, are both required for transcriptional induction of the H. pylori copper resistance determinant CrdA by copper ions. CrdRS-deficient mutants lacked copper induction of crdA expression and were copper sensitive. A direct role of CrdR in transcriptional regulation of crdA was confirmed by in vitro binding of CrdR to the crdA upstream region. A 21-nucleotide sequence located near the crdA promoter was shown to be required for CrdR binding.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Waidner B,Melchers K,Stähler FN,Kist M,Bereswill S

doi

10.1128/JB.187.13.4683-4688.2005

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

4683-8

issue

13

eissn

0021-9193

issn

1098-5530

pii

187/13/4683

journal_volume

187

pub_type

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