A comprehensive study of oxidative stress in patients with somatic symptom disorder.

Abstract:

OBJECTIVE:To investigate oxidative stress parameters [total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase (PON), arylesterase (ARE) and thiol-disulphide homeostasis] in patients who were diagnosed as having somatic symptom disorder in accordance with Diagnostic and Statistical Manual of Mental Disorders-5. METHODS:The study included 41 medication-free patients with somatic symptom disorder and 47 age, sex, and sociodemographic-matched healthy individuals. The patients were administered the Patient Health Questionnaire-15, Somatic Symptom Amplification Scale, Beck Depression Inventory, and Beck Anxiety Inventory. TOS, TAS, OSI, PON, ARE thiol, disulphide levels, and routine biochemical parameters were compared between the two groups. RESULTS:TOS, OSI, disulphide levels, disulphide/native thiol, and disulphide/total thiol ratios were found significantly higher in the patient group compared with the control group (p 0.05). CONCLUSION:This study showed that the level of oxidants increased and oxidative balance was impaired in somatic symptom disorder. Oxidative stress may play a role in the aetiopathogenesis of this disorder. This is the first study to report an association between oxidative stress and somatic symptom disorder.

journal_name

Acta Neuropsychiatr

journal_title

Acta neuropsychiatrica

authors

Kabadayi Sahin E,Caykoylu A,Senat A,Erel O

doi

10.1017/neu.2018.33

subject

Has Abstract

pub_date

2018-12-18 00:00:00

pages

1-6

eissn

0924-2708

issn

1601-5215

pii

S0924270818000339

pub_type

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