Abstract:
OBJECTIVE:To investigate oxidative stress parameters [total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase (PON), arylesterase (ARE) and thiol-disulphide homeostasis] in patients who were diagnosed as having somatic symptom disorder in accordance with Diagnostic and Statistical Manual of Mental Disorders-5. METHODS:The study included 41 medication-free patients with somatic symptom disorder and 47 age, sex, and sociodemographic-matched healthy individuals. The patients were administered the Patient Health Questionnaire-15, Somatic Symptom Amplification Scale, Beck Depression Inventory, and Beck Anxiety Inventory. TOS, TAS, OSI, PON, ARE thiol, disulphide levels, and routine biochemical parameters were compared between the two groups. RESULTS:TOS, OSI, disulphide levels, disulphide/native thiol, and disulphide/total thiol ratios were found significantly higher in the patient group compared with the control group (p 0.05). CONCLUSION:This study showed that the level of oxidants increased and oxidative balance was impaired in somatic symptom disorder. Oxidative stress may play a role in the aetiopathogenesis of this disorder. This is the first study to report an association between oxidative stress and somatic symptom disorder.
journal_name
Acta Neuropsychiatrjournal_title
Acta neuropsychiatricaauthors
Kabadayi Sahin E,Caykoylu A,Senat A,Erel Odoi
10.1017/neu.2018.33subject
Has Abstractpub_date
2018-12-18 00:00:00pages
1-6eissn
0924-2708issn
1601-5215pii
S0924270818000339pub_type
杂志文章abstract:OBJECTIVE:Fas (CD95), commonly categorised as a death receptor due to its well-defined role in apoptosis, can paradoxically also promote neuroprotection. We have previously found that defects in Fas signalling render mice highly susceptible to neural degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mous...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
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abstract:OBJECTIVES:Disturbances in the noradrenergic system, including alterations in the densities of α2-adrenoceptors, are posited to be involved in the pathophysiology of depression. In this study, we investigate the binding of α2-adrenoceptors in regions relevant to depression in an animal model of depression. METHODS:Usi...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
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journal_title:Acta neuropsychiatrica
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doi:10.1111/j.1601-5215.2006.00115.x
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abstract:OBJECTIVES:To investigate how individuals with a history of affective disorder use and perceive their use of social media and online dating. METHODS:A questionnaire focusing on affective disorders and the use of social media and online dating was handed out to outpatients from unipolar depression and bipolar disorder ...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2020.36
更新日期:2020-10-15 00:00:00
abstract::In the training program for residents in psychiatry, scientific education and participation in research projects are relatively underdeveloped. This may result in a gap between recently acquired scientific knowledge and its implementation in clinical practice. Since the start of the residency training in psychiatry in...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800036310
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2007.00188.x
更新日期:2007-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2012.00682.x
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abstract::Patients with panic disorder (PD) report a transient feeling of anxiety upon inhalation of CO2 enriched air. They rate this experience as similar to symptoms of a panic attack. This hypersensitivity has been proposed as an experimental disease model. This paper examines the validity of single breath inhalation of 35% ...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800037030
更新日期:1996-12-01 00:00:00
abstract::Neuroleptic malignant syndrome (NMS) is associated with the administration of antipsychotic agents and other drugs such as l-dopa, antidepressants, and antihistaminic agents. Unexpected changes in mental status, new-onset catatonia, episodic tachycardia, tachypnea, hypertension, dysarthria, dysphagia, diaphoresis, sia...
journal_title:Acta neuropsychiatrica
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abstract:OBJECTIVE:The differentiation between a 'non-organic' depressive episode and an organic depressive disorder on the basis of clinical grounds might be challenging. METHODS:We report a case with an initially typical severe depressive episode without any focal neurological deficits. RESULTS:Only medical history from a t...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章,随机对照试验
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S092427080003622X
更新日期:1999-06-01 00:00:00
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.0924-2708.2006.00121.x
更新日期:2006-02-01 00:00:00
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2012.00671.x
更新日期:2013-04-01 00:00:00
abstract::The alterations in the inflammatory response system (IRS) appear to be quite different between OCD and anorexia nervosa and are also different from the changes observed in major depression. In anorexia nervosa, there is some evidence for increased production of monocytic cytokines, i.e. tumor necrosis factor-α (TNFα) ...
journal_title:Acta neuropsychiatrica
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doi:10.1017/S0924270800035869
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800036838
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pub_type: 杂志文章
doi:10.1111/j.1601-5215.2009.00414.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) are in increasing use in the general population to treat health problems. The objective of the current article is to review the evidence for the rationale and benefit of LCn-3PUFA in the treatment of common psychiatric disorders in children and adoles...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2007.00189.x
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Double depression, the combination of major depression and dysthymia, is associated with poor health-related quality of life (HRQoL) and increased health service utilization. OBJECTIVE:To determine the prevalence of double depression, its associated morbidity and use of health services and antidepressants. ...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2006.00153.x
更新日期:2006-10-01 00:00:00
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2012.00650.x
更新日期:2013-02-01 00:00:00
abstract::BACKGROUND: Yoga therapy (YT) improves cognitive function in healthy individuals, but its impact on cognitive function among persons with schizophrenia (SZ) has not been investigated. AIMS: Evaluate adjunctive YT for cognitive domains impaired in SZ. METHODS: Patients with SZ received YT or treatment as usual (TAU; ...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2011.00587.x
更新日期:2012-04-01 00:00:00
abstract:INTRODUCTION AND AIM:Posttraumatic stress disorder (PTSD) is associated with increased medical morbidity, particularly from the autoimmune and cardiovascular diseases. Changes in the endocrine and immune system are key mediators in this process. The aim of our study was to investigate weather hormones (cortisol and pro...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
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更新日期:2009-06-01 00:00:00
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journal_title:Acta neuropsychiatrica
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更新日期:2002-08-01 00:00:00
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800037376
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Schizophrenia is consistently associated with lower IQ compared to the IQ of control groups, or estimated premorbid IQ. It is not likely that the IQ scores deteriorate during the prodromal phase or first psychotic episode; they are already present before the onset of the prodromal phase and have been detecte...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1034/j.1601-5215.2002.140302.x
更新日期:2002-06-01 00:00:00