Depression as first manifestation of a large intracerebral lymphoma.

Abstract:

OBJECTIVE:The differentiation between a 'non-organic' depressive episode and an organic depressive disorder on the basis of clinical grounds might be challenging. METHODS:We report a case with an initially typical severe depressive episode without any focal neurological deficits. RESULTS:Only medical history from a third party raised doubts about this provisional diagnosis. Brain magnetic resonance imaging revealed a highly malignant diffuse large intracerebral B-cell lymphoma in the right frontal lobe changing the diagnosis into an organic depressive disorder. The patient recovered after neurosurgical resection, chemotherapy and autologous stem cell transplantation. CONCLUSION:This report helps to reduce possible errors in the differential diagnosis of depressive disorders by underlining the importance of a comprehensive medical history including anamnesis from a third party and neuroimaging, especially in first or atypical manifestation of depressive disorders.

journal_name

Acta Neuropsychiatr

journal_title

Acta neuropsychiatrica

authors

Etgen T,Fleissner S

doi

10.1017/neu.2013.19

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

248-50

issue

4

eissn

0924-2708

issn

1601-5215

pii

S0924270813000197

journal_volume

25

pub_type

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