Cytokines in de obsessief compulsieve stoornis en in anorexia nervosa: een overzicht.

Abstract:

:The alterations in the inflammatory response system (IRS) appear to be quite different between OCD and anorexia nervosa and are also different from the changes observed in major depression. In anorexia nervosa, there is some evidence for increased production of monocytic cytokines, i.e. tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6), and decreased production of Th-1 like cytokines, i.e. IL-2 and IFNγ. In the same patients there are also signs of immunosuppression, e.g. lowered numbers of CD4 and CD8 T cells and increased production of transforming growth factor-beta (TGFβ). The increased production of monocytic cytokines may be the consequence of the hyponutritional status of those patients. The diminished production of the Th-1 like cytokines may be the consequence of at least four different factors: 1) the deficiency in nutritional factors; 2) neuroendocrine disorders, such as increased Cortisol production; 3) the increased TGFβ production; and 4) lower serum dipeptidyl peptidase activity. In OCD no consistent or specific alterations in the IRS are observed. There is no evidence that IRS activation may play a role in the pathophysiology of OCD and anorexia nervosa.

journal_name

Acta Neuropsychiatr

journal_title

Acta neuropsychiatrica

authors

van West D,Maes M

doi

10.1017/S0924270800035869

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

125-9

issue

4

eissn

0924-2708

issn

1601-5215

pii

S0924270800035869

journal_volume

11

pub_type

杂志文章
  • Brain 5-HT function in bipolar affective disorder.

    abstract:BACKGROUND:Previous studies suggest that brain serotonin neurotransmission may mediate the actions of lithium carbonate. Acute tryptophan depletion (ATD) reduces brain serotonin and allows the study of this neurotransmitter in patient groups. Serotonin modulates electroencephalographic (EEG) activity, which is abnormal...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1017/S0924270800035481

    authors: Young AH,Hughes JH,Ashton CH

    更新日期:2000-09-01 00:00:00

  • Recognition memory abnormalities in asymptomatic biological parents of a patient with schizophrenia.

    abstract:BACKGROUND:Recognition memory dysfunction has been frequently reported in schizophrenic populations, and has been linked with the development of delusions and thought disorder. A range of neuropsychological abnormalities have also been documented in the biological asymptomatic relatives of patients with schizophrenia; ...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1034/j.1601-5215.2003.00044.x

    authors: Edelstyn NM,Drakeford J,Oyebode F,Findlay CD

    更新日期:2003-10-01 00:00:00

  • Assessment of the hypothalamic-pituitary-adrenal axis activity: glucocorticoid receptor and mineralocorticoid receptor function in depression with early life stress - a systematic review.

    abstract:OBJECTIVE:The mechanisms involved in the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, especially in the functioning of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) in depressed patients, are not well elucidated. The objective of this study was to conduct a systematic review of art...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1111/j.1601-5215.2011.00610.x

    authors: Von Werne Baes C,de Carvalho Tofoli SM,Martins CM,Juruena MF

    更新日期:2012-02-01 00:00:00

  • Safety, tolerability and efficacy of a rapid dose escalation of quetiapine in bipolar I mania: the FATIMA study.

    abstract:OBJECTIVE:The FATIMA study (FAst TItration of quetiapine fumarate in bipolar I MAnia) evaluated the safety, tolerability and efficacy of a rapid dose escalation of quetiapine in acutely ill bipolar I patients experiencing a manic episode. METHODS:In an open-label, phase II pilot study, 29 patients aged 18 years or old...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1111/j.1601-5215.2009.00378.x

    authors: Constant E,Seghers A,Ranalli E,Ryckmans V,Snauwaert P,Parent M,Vandenhoven G

    更新日期:2009-06-01 00:00:00

  • Good news regarding SSRI safety in Danish meta-analysis.

    abstract::In two previous letters on an selective serotonin reuptake inhibitor (SSRI) meta-analysis conducted by the Copenhagen Trial Unit at Copenhagen University Hospital, we have commented on a large number of errors, almost all of which have tilted the results in an anti-drug direction, that unfortunately mar this publicati...

    journal_title:Acta neuropsychiatrica

    pub_type: 评论,杂志文章

    doi:10.1017/neu.2019.42

    authors: Hieronymus F,Lisinski A,Näslund J,Eriksson E

    更新日期:2020-02-01 00:00:00

  • Neuroticism, alexithymia, negative affect and positive affect as predictors of medically unexplained symptoms in primary care.

    abstract:BACKGROUND:Somatization has been defined in a number of ways. Despite their differences, these definitions have one element in common, namely the presence of somatic symptoms that cannot be explained (adequately) by organic findings. OBJECTIVE:The primary objectives of the dissertation were to gain a better insight in...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1034/j.1601-5215.2002.140404.x

    authors: De Gucht V

    更新日期:2002-08-01 00:00:00

  • In vitro effect of antipsychotics on brain energy metabolism parameters in the brain of rats.

    abstract:OBJECTIVE:Typical and atypical antipsychotic drugs have been shown to have different clinical, biochemical and behavioural profiles. It is well described that impairment of metabolism, especially in the mitochondria, leads to oxidative stress and neuronal death and has been implicated in the pathogenesis of a number of...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1111/j.1601-5215.2012.00650.x

    authors: Scaini G,Rochi N,Morais MO,Maggi DD,De-Nês BT,Quevedo J,Streck EL

    更新日期:2013-02-01 00:00:00

  • The role of serotonin in panic: evidence from tryptophan depletion studies.

    abstract::There has been growing interest in the role of serotonin (5-hydroxytryptamine, 5-HT) in anxiety, including pathological states such as panic disorder. The technique of tryptophan depletion (TD), which causes an acute, temporary and reversible reduction in brain 5-HT levels, is a useful minimally invasive paradigm to a...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1111/j.0924-2708.2004.0081.x

    authors: Pyle AC,Argyropoulos SV,Nutt DJ

    更新日期:2004-04-01 00:00:00

  • Low IQ scores in schizophrenia: primary or secondary deficit?

    abstract:BACKGROUND:Schizophrenia is consistently associated with lower IQ compared to the IQ of control groups, or estimated premorbid IQ. It is not likely that the IQ scores deteriorate during the prodromal phase or first psychotic episode; they are already present before the onset of the prodromal phase and have been detecte...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1034/j.1601-5215.2002.140302.x

    authors: van Beilen M,Withaar F,van Zomeren AH,van den Bosch R

    更新日期:2002-06-01 00:00:00

  • Adjunctive cognitive remediation for schizophrenia using yoga: an open, non-randomized trial.

    abstract::BACKGROUND: Yoga therapy (YT) improves cognitive function in healthy individuals, but its impact on cognitive function among persons with schizophrenia (SZ) has not been investigated. AIMS: Evaluate adjunctive YT for cognitive domains impaired in SZ. METHODS: Patients with SZ received YT or treatment as usual (TAU; ...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1111/j.1601-5215.2011.00587.x

    authors: Bhatia T,Agarwal A,Shah G,Wood J,Richard J,Gur RE,Gur RC,Nimgaonkar VL,Mazumdar S,Deshpande SN

    更新日期:2012-04-01 00:00:00

  • The prospects of new antipsychotic principles.

    abstract::Biological schizophrenia research has been dominated by the dopamine hypothesis for decades, but in recent years a more diversified view has gained increasing attention. Several neurotransmitters are now being discussed, and especially their interaction in complex circuitries. The demonstration of an atypical profile ...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1017/S0924270800036838

    authors: Carlsson A

    更新日期:1997-06-01 00:00:00

  • Correlation between amygdala volume and impulsivity in adults with attention-deficit hyperactivity disorder.

    abstract:BACKGROUND:Attention-deficit hyperactivity disorder (ADHD) is a chronic neurobiological disorder with childhood onset and persistence through adolescence and adulthood. ADHD patients frequently show exaggerated emotional responses. The amygdala plays an important role in emotion processing and in the activation of the ...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1017/neu.2015.34

    authors: Tajima-Pozo K,Ruiz-Manrique G,Yus M,Arrazola J,Montañes-Rada F

    更新日期:2015-12-01 00:00:00

  • Characterisation and outcome of neuropsychiatric symptoms in patients with anti-NMDAR encephalitis.

    abstract:BACKGROUND:Encephalitis due to anti-N-methyl-D-aspartate receptor antibodies (ANMDARE) is the most frequent immune-mediated encephalitis. It is distinguished by the subacute onset of neuropsychiatric symptoms. OBJECTIVE:To evaluate the characteristic neuropsychiatric symptoms and their outcome in patients diagnosed wi...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1017/neu.2019.46

    authors: Restrepo-Martinez M,Ramirez-Bermudez J,Bayliss L,Espinola-Nadurille M

    更新日期:2020-04-01 00:00:00

  • The developing role of pharmacogenetics in psychiatry.

    abstract::A great interindividual variability exists in biological response to drugs. This variability is partly attributable to pharmacodynamic factors (drug - receptor interactions) and partly to pharmacokinetic factors. Drugs can be eliminated from the body by renal clearance, metabolism or both. Although every tissue has so...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1017/S092427080003622X

    authors: Touw DJ

    更新日期:1999-06-01 00:00:00

  • Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression.

    abstract:OBJECTIVE:There is clear evidence of a genetic component in major depression, and several studies indicate that neuropeptide Y (NPY) could play an important role in the pathophysiology of the disease. A well-known polymorphism encoding the substitution of leucine to proline in the signal peptide sequence of NPY (Leu7Pr...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1111/j.1601-5215.2011.00600.x

    authors: Koefoed P,Woldbye DP,Hansen TV,Eplov LF,Christiansen SH,Mors O,Kessing LV,Werge T,Kaipio K,Pesonen U,Fahmy T,Mellerup E,Jakobsen KD,Hansen ES,Knudsen GM,Bukh JD,Bock C,Lindberg C,Kristensen AS,Dam H,Nordentoft M,

    更新日期:2012-04-01 00:00:00

  • Integratie van opleiding en onderzoek in de opleiding tot psychiater.

    abstract::In the training program for residents in psychiatry, scientific education and participation in research projects are relatively underdeveloped. This may result in a gap between recently acquired scientific knowledge and its implementation in clinical practice. Since the start of the residency training in psychiatry in...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1017/S0924270800036310

    authors: Verhoeven WM,Goessens LF,van den Berg YW,Tuinier S

    更新日期:1999-03-01 00:00:00

  • Comparing running therapy with physiotraining therapy in the treatment of mood disorders.

    abstract:BACKGROUND:Despite various studies, supportive evidence for the efficacy of exercise in treatment of mental illness is still weak. OBJECTIVE:The aim of this study was to compare two forms of exercise, namely running therapy (RT) and physiotraining therapy (PT), on stationary devices. METHODS:Patients in a day treatme...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1111/j.1601-5215.2006.00115.x

    authors: Judith Haffmans PM,Kleinsman AC,van Weelden C,Huijbrechts IP,Hoencamp E

    更新日期:2006-06-01 00:00:00

  • A Ventral Prefrontal-Amygdala Neural System in Bipolar Disorder: A View from Neuroimaging Research.

    abstract::In the past decade, neuroimaging research has identified key components in the neural system that underlies bipolar disorder (BD). The ventral prefrontal cortex (VPFC) and amygdala are highly interconnected structures that jointly play a central role in emotional regulation. Numerous research groups have reported prom...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:

    authors: Womer FY,Kalmar JH,Wang F,Blumberg HP

    更新日期:2009-09-23 00:00:00

  • Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression.

    abstract:OBJECTIVE:This study aimed to explore effects of adjunctive treatment with N-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar depression. METHODS:This is a secondary analysis of a placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, and week 32 of the open-...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/neu.2018.13

    authors: Panizzutti B,Bortolasci C,Hasebe K,Kidnapillai S,Gray L,Walder K,Berk M,Mohebbi M,Dodd S,Gama C,Magalhães PV,Cotton SM,Kapczinski F,Bush AI,Malhi GS,Dean OM

    更新日期:2018-12-01 00:00:00

  • Associations between C-reactive protein levels and cognition during the first 6 months after acute psychosis.

    abstract:OBJECTIVE:Inverse relationships between the C-reactive protein (CRP) levels and cognitive performance in acute psychosis have been demonstrated. We aimed to investigate how the serum level and initial change of CRP in acutely admitted patients with psychosis was correlated with cognitive performance during a 6-months f...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1017/neu.2018.25

    authors: Fathian F,Løberg EM,Gjestad R,Steen VM,Kroken RA,Jørgensen HA,Johnsen E

    更新日期:2019-02-01 00:00:00

  • Anxiety and styles of coping with occupational stress resulting from work with 'dangerous' prisoners in prison service officers.

    abstract:OBJECTIVE:Prisoners categorised as 'dangerous' are a category of prisoners that require and/or force into using special measures of caution, protection and security. The aim of the study was to examine the intensity of anxiety (as a state and as a trait) experienced by officers working with 'dangerous' prisoners and st...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1017/neu.2015.31

    authors: Tsirigotis K,Gruszczyński W,Pęczkowski S

    更新日期:2015-10-01 00:00:00

  • Putting the brain in Jeopardy: a novel comprehensive and expressive language task?

    abstract:OBJECTIVE:To develop and test a novel fMRI compatible comprehensive and expressive language task that reliably and predictably activates both Wernicke's and Broca's cortical brain regions, respectively, and has utility for the determination of hemispheric language dominance. METHODS:Ten healthy men (seven) and women (...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1111/j.1601-5215.2006.00134.x

    authors: Berntsen EM,Rasmussen IA,Samuelsen P,Xu J,Haraldseth O,Lagopoulos J,Malhi GS

    更新日期:2006-04-01 00:00:00

  • Interferon, tryptophan and depression.

    abstract::Depression is a frequent comorbid disorder of many inflammatory diseases and it is suggested that brain inflammatory processes have a pathogenic role in mood dysregulation. Several immunocompromised patients have been treated with cytokines and long-term treatments have resulted in a variety of neuropsychiatric side-e...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1034/j.1601-5215.2003.00007.x

    authors: Fekkes D,Van Gool AR

    更新日期:2003-02-01 00:00:00

  • Is CO2 inhalation a specific marker for panic disorder? An experimental panic model.

    abstract::Patients with panic disorder (PD) report a transient feeling of anxiety upon inhalation of CO2 enriched air. They rate this experience as similar to symptoms of a panic attack. This hypersensitivity has been proposed as an experimental disease model. This paper examines the validity of single breath inhalation of 35% ...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1017/S0924270800037030

    authors: Griez E

    更新日期:1996-12-01 00:00:00

  • Possible association between G-protein β3 subunit C825T polymorphism and antipsychotic-induced restless legs syndrome in schizophrenia.

    abstract:OBJECTIVE:The incidence of restless legs syndrome (RLS) is presumed to be higher among people with schizophrenia who take antipsychotic medication, most of which blocks the dopamine D2 receptor. The purpose of this study was to determine whether the G-protein β3 subunit (GNB3) C825T polymorphism is associated with anti...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1111/j.1601-5215.2007.00240.x

    authors: Kang SG,Lee HJ,Choi JE,Park JH,Lee SS,Han C,Kim YK,Kim SH,Lee MS,Joe SH,Jung IK,Kim L

    更新日期:2007-12-01 00:00:00

  • Temperament and Character Inventory (TCI) in adolescents with anorexia nervosa.

    abstract:BACKGROUND:Female patients with anorexia nervosa differ significantly from the control women in various dimensions of personality. OBJECTIVE:To investigate the personality dimensions measured with the Temperament and Character Inventory (TCI) in adolescent patients with restrictive-type and bulimic/purging-type anorex...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1111/j.0924-2708.2004.00073.x

    authors: Rybakowski F,Slopien A,Zakrzewska M,Hornowska E,Rajewski A

    更新日期:2004-06-01 00:00:00

  • Gene polymorphisms and response to transcranial direct current stimulation for auditory verbal hallucinations in schizophrenia.

    abstract:OBJECTIVE:Recent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong asso...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1017/neu.2018.4

    authors: Chhabra H,Shivakumar V,Subbanna M,Kalmady SV,Bose A,Agarwal SM,Sreeraj VS,Dinakaran D,Narayanaswamy JC,Debnath M,Venkatasubramanian G

    更新日期:2018-08-01 00:00:00

  • Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test.

    abstract:OBJECTIVE:Ginsenosides, biologically-active components of the root of Panax ginseng, have been reported to have therapeutic benefits in a number of disease states including psychiatric conditions such as major depressive disorder. Our objective was to determine if a standardized commercial ginseng extract, G115®, could...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1017/neu.2021.2

    authors: Terstege DJ,MacDonald DS,Tasker RA

    更新日期:2021-01-22 00:00:00

  • A randomised, placebo-controlled trial of transcranial pulsed electromagnetic fields in patients with multiple chemical sensitivity.

    abstract:OBJECTIVE:To evaluate the efficacy of transcranially applied pulsed electromagnetic fields (PEMF) on functional impairments and symptom severity in multiple chemical sensitivity (MCS) patients. METHODS:The study was conducted as a nationwide trial in Denmark using a randomised, parallel-group, double-blind and placebo...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/neu.2016.51

    authors: Tran MTD,Skovbjerg S,Arendt-Nielsen L,Christensen KB,Elberling J

    更新日期:2017-10-01 00:00:00

  • Serum lipid peroxidation markers are correlated with those in brain samples in different stress models.

    abstract:OBJECTIVE:Stress can stimulate increased production of oxygen radicals. We investigated the correlations between serum levels of lipid peroxidation markers and those in brain samples in different stress models. METHODS:Animals (n = 96) were divided equally into eight groups: a control group and groups treated with vit...

    journal_title:Acta neuropsychiatrica

    pub_type: 杂志文章

    doi:10.1017/neu.2013.32

    authors: Celikbilek A,Gocmen AY,Tanik N,Yaras N,Yargicoglu P,Gumuslu S

    更新日期:2014-02-01 00:00:00