Abstract:
OBJECTIVE:The incidence of restless legs syndrome (RLS) is presumed to be higher among people with schizophrenia who take antipsychotic medication, most of which blocks the dopamine D2 receptor. The purpose of this study was to determine whether the G-protein β3 subunit (GNB3) C825T polymorphism is associated with antipsychotic-induced RLS in schizophrenia. METHODS:We examined 178 Korean patients with schizophrenia. All of the subjects were evaluated using the diagnostic criteria of the International Restless Legs Syndrome Study Group and the International Restless Legs Scale. Genotyping was performed for the C825T polymorphism in the GNB3 gene. RESULTS:The genotype distribution did not differ significantly between antipsychotic-induced RLS patients and patients who had no-RLS symptoms (χ 2 = 4.30, p = 0.116). The genotypes of the C825T single-nucleotide polymorphism (SNP) were classified into two groups: C+ (CC and CT genotypes) and C- (TT genotype). The presence of the C allele (C+) was associated with an increased likelihood of RLS (χ 2 = 4.14, p = 0.042; odds ratio = 2.56, 95% confidence interval = 1.02-6.47). CONCLUSIONS:These results suggest that the GNB3 C825T SNP is associated with RLS in schizophrenia. However, confirming this association requires future larger scale studies in which the effects of medication are strictly controlled.
journal_name
Acta Neuropsychiatrjournal_title
Acta neuropsychiatricaauthors
Kang SG,Lee HJ,Choi JE,Park JH,Lee SS,Han C,Kim YK,Kim SH,Lee MS,Joe SH,Jung IK,Kim Ldoi
10.1111/j.1601-5215.2007.00240.xsubject
Has Abstractpub_date
2007-12-01 00:00:00pages
351-6issue
6eissn
0924-2708issn
1601-5215pii
S0924270800002441journal_volume
19pub_type
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
abstract::Objective This study explored the utility of the Health Belief Models (HBM) in explaining medication adherence in subjects with severe affective disorders. Method Well established measuring instruments, with confirmed reliability and validity, were used to assess each component of two HBMs and adherence with mood stab...
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abstract:OBJECTIVE:Psychometric research in the field of alcohol dependence has concentrated on identifying certain (personality) characteristics (i.e. typologies). This paper is aimed to identify such typologies and studies the relation of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) and Cloninger's temperament-c...
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更新日期:2002-10-01 00:00:00
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更新日期:2003-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-12-01 00:00:00
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更新日期:2020-10-15 00:00:00
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更新日期:2003-10-01 00:00:00
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更新日期:2010-06-01 00:00:00
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更新日期:2006-02-01 00:00:00