Long chain omega-3 polyunsaturated fatty acids in the treatment of psychiatric illnesses in children and adolescents.

Abstract:

OBJECTIVE:Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) are in increasing use in the general population to treat health problems. The objective of the current article is to review the evidence for the rationale and benefit of LCn-3PUFA in the treatment of common psychiatric disorders in children and adolescents. METHODS:A search of Psychlit, PubMed and Cochrane Databases was conducted using the terms child, adolescent, bipolar, depression, psychosis, first-episode psychosis, schizophrenia, attention deficit hyperactivity disorder (ADHD), autism, psychiatric, omega-3, n-3, docosahexaenoic acid and eicosapentaenoic acid. Further studies were identified from the bibliographies of published reviews. RESULTS:One small randomized controlled trial with LCn-3PUFA supplementation in depression in children found a small beneficial effect over placebo. Four placebo-controlled trials showed uncertain benefit of LCn-3PUFA for ADHD. Single placebo-controlled trials showed no benefit in autism or bipolar disorder. There is an absence of studies examining benefit for first-episode psychosis or schizophrenia in children and adolescents. CONCLUSIONS:While children and adolescents are receiving LCn-3PUFA for a range of psychiatric indications, there is only evidence of likely benefit for unipolar depression.

journal_name

Acta Neuropsychiatr

journal_title

Acta neuropsychiatrica

authors

Clayton EH,Hanstock TL,Garg ML,Hazell PL

doi

10.1111/j.1601-5215.2007.00189.x

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

92-103

issue

2

eissn

0924-2708

issn

1601-5215

pii

S0924270800003033

journal_volume

19

pub_type

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