Comparison of language impairment in late-onset depression and Alzheimer's disease.

Abstract:

OBJECTIVES:Depression and dementia are highly prevalent in the elderly. Language impairment is an inherent component of Alzheimer's disease (AD), which can also be encountered in depressed patients. The aim of this study wasto compare the profiles of language abilities in late-onset depression and mild AD groups. METHODS:We studied 25 patients with late-onset depression (mean age 73.6 ± 6.6 years; schooling 9.1 ± 5.7 years) and 30 patients with mild AD (77.6 ± 5.4 years; 7.5 ± 7.1 years) using the Arizona Battery for Communication Disorders of Dementia (ABCD), compared to a group of 30 controls (73.8 ± 5.8 years; 9.1 ± 5.4 years). Cut-off scores to discriminate between Controls × Depression and Depression × AD were determined. RESULTS:Depressed patients' scores were similar to AD in confrontation naming, concept definition, following commands, repetition and reading comprehension (sentence). Episodic memory and mental status subtests were useful in differentiating depressed patients from AD, a result that was reproduced when using analysis of covariance to control for the effect of age in the same subtests (p = 0.01 and 0.04, respectively). CONCLUSION:Language impairment resembling AD was found in the aforementioned language subtests of the ABCD in elderly depressed patients; the mental status and episodic memory subtests were useful to discriminate between AD and depression. The ABCD has proven to be a suitable tool for language evaluation in this population and should aid in the differentiation of AD and pseudodementia (as that of depression).

journal_name

Acta Neuropsychiatr

journal_title

Acta neuropsychiatrica

authors

da Silva Novaretti TM,D'Ávila Freitas MI,Mansur LL,Nitrini R,Radanovic M

doi

10.1111/j.1601-5215.2011.00526.x

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

62-8

issue

2

eissn

0924-2708

issn

1601-5215

pii

S0924270800026454

journal_volume

23

pub_type

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