Abstract:
BACKGROUND:Double depression, the combination of major depression and dysthymia, is associated with poor health-related quality of life (HRQoL) and increased health service utilization. OBJECTIVE:To determine the prevalence of double depression, its associated morbidity and use of health services and antidepressants. METHODS:A random and representative sample of the South Australian general population was interviewed. The mood module of the Primary Care Evaluation of Mental Disorders (PRIME-MD), the Short-Form Health Status Questionnaire (SF-36) and Assessment of Quality of Life (AQoL) instruments were administered, and data relating to health service utilization, antidepressant use and role functioning were collected. RESULTS:Double depression was present in 3.3% of the population. The use of health services was significantly higher in this group than those with no depression, or dysthymia or major depression alone. Only 15.2% had attended a community health service, 18.2% had seen a psychiatrist, 10.1% a psychologist, 16.2% a social worker and 9.1% any other counsellor in the last month. While 41.4% were currently taking an antidepressant, the average doses of the two most commonly prescribed antidepressants were below the maximum recommended doses, and the use of antidepressant augmentation strategies was also minimal. CONCLUSIONS:While double depression is associated with increased morbidity and use of health services, the optimum use of both pharmacological and nonpharmacological treatments is clearly lacking in this community sample.
journal_name
Acta Neuropsychiatrjournal_title
Acta neuropsychiatricaauthors
Goldney RD,Bain MAdoi
10.1111/j.1601-5215.2006.00153.xsubject
Has Abstractpub_date
2006-10-01 00:00:00pages
210-5issue
5eissn
0924-2708issn
1601-5215pii
S0924270800003392journal_volume
18pub_type
杂志文章abstract:OBJECTIVE:Typical and atypical antipsychotic drugs have been shown to have different clinical, biochemical and behavioural profiles. It is well described that impairment of metabolism, especially in the mitochondria, leads to oxidative stress and neuronal death and has been implicated in the pathogenesis of a number of...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2012.00650.x
更新日期:2013-02-01 00:00:00
abstract::Most forms of behaviour whether normal or abnormal, show a tendency to run in families. However, these can range from symptoms of dementia and movement disorder caused by the comparatively rare autosomal dominant Huntington's disease to common everyday aspects of behaviour such as religious persuasion or career choice...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800036127
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to analyse demographic and clinical characteristics, as well as psychiatric diagnoses to identify gender differences in patients with attempted suicide in a Mexican population. METHODS:Between September 2010 and September 2012, 140 suicide attempts were documented in the Depa...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2015.6
更新日期:2015-06-01 00:00:00
abstract::A psychofysiological study of the cardiac adaptivity to attention-demanding reaction time tasks demonstrated that children with a lesser variant of the pervasive developmental disorder (DSM-IV: PDDNOS) exhibit less cardiac responsiveness to attention tasks than healthy children do. We studied changes in heart rate var...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S092427080003605X
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the involvement of nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome in schizophrenia-like behaviour in young animals exposed to maternal immune activation (MIA). METHODS:To this aim, on the 15th gestational day, the females received an injection of lipopolysaccharides. Whe...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2020.27
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:The aims of this study were to determine the dominant affective temperament changes in stroke survivors and whether temperament affects the disability. METHODS:A total of 63 stroke patients were included in this study. Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire was used to...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2008.00335.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To review the literature comparing electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) for major depression. METHODS:Data from the six randomised, prospective studies were agglutinated into one data set. Special attention was given to the methods of both TMS and ECT as well as data pe...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2008.00333.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of and factors associated with depression and stress with perceived quality of life and the salivary cortisol levels in Community Health Agent (CHA). Materials and Methods Cross-sectional descriptive study of CHAs in Pelotas-RS, Brazil. Data collection, including sociodemographic i...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2015.58
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) are in increasing use in the general population to treat health problems. The objective of the current article is to review the evidence for the rationale and benefit of LCn-3PUFA in the treatment of common psychiatric disorders in children and adoles...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2007.00189.x
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:To investigate how individuals with a history of affective disorder use and perceive their use of social media and online dating. METHODS:A questionnaire focusing on affective disorders and the use of social media and online dating was handed out to outpatients from unipolar depression and bipolar disorder ...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2020.36
更新日期:2020-10-15 00:00:00
abstract::The elucidation of sleep regulation is not an easy task. On one side, there is a multitude of solid yet disparate data, on the other side, the topic is tempting for engaging in wild speculation, particularly with respect to the functions of sleep. Models may exert a moderating influence by mediating between the two ex...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800037443
更新日期:1995-06-01 00:00:00
abstract:OBJECTIVE:To investigate gender differences in psychiatric comorbidity patients diagnosed with attention-deficit hyperactivity disorder (ADHD) as adults. METHODS:Interviews about current ADHD symptoms and psychiatric comorbidity on axis I and II (Structured Clinical Interview for DSM-IV axis I and axis II) were conduc...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2012.00682.x
更新日期:2013-06-01 00:00:00
abstract::In this first part of a review on recent insights into the structure and function of the γ-aminobuty rie acid type A - benzodiazepine receptor system, the γ-aminobutyric acid type A (GABAA) receptor and the different types of benzodiazepine (BDZ) receptors known at this moment are dicussed. GABAA- and BDZ receptors ar...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800037078
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:Post-traumatic stress disorder (PTSD) displays high co-morbidity with major depression and treatment-resistant depression (TRD). Earlier work demonstrated exaggerated depressive-like symptoms in a gene×environment model of TRD and an abrogated response to imipramine. We extended the investigation by studying ...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2016.50
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:Inverse relationships between the C-reactive protein (CRP) levels and cognitive performance in acute psychosis have been demonstrated. We aimed to investigate how the serum level and initial change of CRP in acutely admitted patients with psychosis was correlated with cognitive performance during a 6-months f...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2018.25
更新日期:2019-02-01 00:00:00
abstract::Biological schizophrenia research has been dominated by the dopamine hypothesis for decades, but in recent years a more diversified view has gained increasing attention. Several neurotransmitters are now being discussed, and especially their interaction in complex circuitries. The demonstration of an atypical profile ...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800036838
更新日期:1997-06-01 00:00:00
abstract::Melatonin is a hormone secreted by the pineal gland mainly during the night. The discovery that this melatonin secretion decreases under the influence of bright light, gave rise to the use of light therapy in some affective disorders. The literature on the relationship between melatonin secretion and mood is reviewed ...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800037376
更新日期:1995-09-01 00:00:00
abstract::BACKGROUND: Aberrant electrophysiological and hemodynamic processing of auditory oddball stimuli is among the most robustly documented findings in patients with schizophrenia. However, no study to date has directly examined linked patterns of electrical and hemodynamic differences in patients and controls. METHODS: I...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2010.00467.x
更新日期:2010-06-01 00:00:00
abstract::In the past decade, neuroimaging research has identified key components in the neural system that underlies bipolar disorder (BD). The ventral prefrontal cortex (VPFC) and amygdala are highly interconnected structures that jointly play a central role in emotional regulation. Numerous research groups have reported prom...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:
更新日期:2009-09-23 00:00:00
abstract:OBJECTIVE:To investigate oxidative stress parameters [total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase (PON), arylesterase (ARE) and thiol-disulphide homeostasis] in patients who were diagnosed as having somatic symptom disorder in accordance with Diagnostic and Stat...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2018.33
更新日期:2018-12-18 00:00:00
abstract:OBJECTIVE:To develop and test a novel fMRI compatible comprehensive and expressive language task that reliably and predictably activates both Wernicke's and Broca's cortical brain regions, respectively, and has utility for the determination of hemispheric language dominance. METHODS:Ten healthy men (seven) and women (...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2006.00134.x
更新日期:2006-04-01 00:00:00
abstract::In the training program for residents in psychiatry, scientific education and participation in research projects are relatively underdeveloped. This may result in a gap between recently acquired scientific knowledge and its implementation in clinical practice. Since the start of the residency training in psychiatry in...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800036310
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:The incidence of restless legs syndrome (RLS) is presumed to be higher among people with schizophrenia who take antipsychotic medication, most of which blocks the dopamine D2 receptor. The purpose of this study was to determine whether the G-protein β3 subunit (GNB3) C825T polymorphism is associated with anti...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2007.00240.x
更新日期:2007-12-01 00:00:00
abstract::BACKGROUND: Yoga therapy (YT) improves cognitive function in healthy individuals, but its impact on cognitive function among persons with schizophrenia (SZ) has not been investigated. AIMS: Evaluate adjunctive YT for cognitive domains impaired in SZ. METHODS: Patients with SZ received YT or treatment as usual (TAU; ...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2011.00587.x
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:The mechanisms involved in the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, especially in the functioning of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) in depressed patients, are not well elucidated. The objective of this study was to conduct a systematic review of art...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2011.00610.x
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:Prisoners categorised as 'dangerous' are a category of prisoners that require and/or force into using special measures of caution, protection and security. The aim of the study was to examine the intensity of anxiety (as a state and as a trait) experienced by officers working with 'dangerous' prisoners and st...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2015.31
更新日期:2015-10-01 00:00:00
abstract::Depression is a frequent comorbid disorder of many inflammatory diseases and it is suggested that brain inflammatory processes have a pathogenic role in mood dysregulation. Several immunocompromised patients have been treated with cytokines and long-term treatments have resulted in a variety of neuropsychiatric side-e...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1034/j.1601-5215.2003.00007.x
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:We investigated whether the nitric oxide (NO) precursor, L-arginine, can prevent the antidepressant-like action of the fast-acting antidepressant, ketamine, in a genetic rat model of depression, and/or induce changes in the glutamate (Glu)/N-methyl-D-aspartate receptor (NMDAR)/NO/cyclic guanosine monophosphat...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2014.39
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:Disturbances in the noradrenergic system, including alterations in the densities of α2-adrenoceptors, are posited to be involved in the pathophysiology of depression. In this study, we investigate the binding of α2-adrenoceptors in regions relevant to depression in an animal model of depression. METHODS:Usi...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2015.24
更新日期:2015-12-01 00:00:00
abstract::Immunopathogenesis of multiple sclerosis is a complex process involving T cell mediated autoimmunity at initial stage of disease. A long standing view that Th1 cells are critical for early inflammatory development of lesions is challenging by recent findings that Th1 helper cells with Th17 phenotype are even more impo...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800032622
更新日期:2009-06-01 00:00:00