Abstract:
OBJECTIVE:To develop and test a novel fMRI compatible comprehensive and expressive language task that reliably and predictably activates both Wernicke's and Broca's cortical brain regions, respectively, and has utility for the determination of hemispheric language dominance. METHODS:Ten healthy men (seven) and women (three) were administered a task based on the television game Jeopardy that was adapted for fMRI presentation. The task was programmed using E-PRIME software and designed to run as an event-related experiment. The study was conducted on 3 T MRI Phillips Intera scanner, and data was anlysed using Brain Voyager QX. All subjects provided written informed consent. RESULTS:The Jeopardy task produced robust left hemisphere activation in regions corresponding to Wernicke's and Broca's areas. CONCLUSION:This novel fMRI compatible task (Jeopardy) reliably maps both Broca's and Wernicke's areas with robust hemispheric lateralization. It is potentially useful in language localization studies as it offers advantages over conventional procedures and other fMRI tasks by virtue of being non-invasive and mapping both language areas in one experiment.
journal_name
Acta Neuropsychiatrjournal_title
Acta neuropsychiatricaauthors
Berntsen EM,Rasmussen IA,Samuelsen P,Xu J,Haraldseth O,Lagopoulos J,Malhi GSdoi
10.1111/j.1601-5215.2006.00134.xsubject
Has Abstractpub_date
2006-04-01 00:00:00pages
115-9issue
2eissn
0924-2708issn
1601-5215pii
S0924270800003598journal_volume
18pub_type
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-06-01 00:00:00
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journal_title:Acta neuropsychiatrica
pub_type: 杂志文章,随机对照试验
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