Putting the brain in Jeopardy: a novel comprehensive and expressive language task?

Abstract:

OBJECTIVE:To develop and test a novel fMRI compatible comprehensive and expressive language task that reliably and predictably activates both Wernicke's and Broca's cortical brain regions, respectively, and has utility for the determination of hemispheric language dominance. METHODS:Ten healthy men (seven) and women (three) were administered a task based on the television game Jeopardy that was adapted for fMRI presentation. The task was programmed using E-PRIME software and designed to run as an event-related experiment. The study was conducted on 3 T MRI Phillips Intera scanner, and data was anlysed using Brain Voyager QX. All subjects provided written informed consent. RESULTS:The Jeopardy task produced robust left hemisphere activation in regions corresponding to Wernicke's and Broca's areas. CONCLUSION:This novel fMRI compatible task (Jeopardy) reliably maps both Broca's and Wernicke's areas with robust hemispheric lateralization. It is potentially useful in language localization studies as it offers advantages over conventional procedures and other fMRI tasks by virtue of being non-invasive and mapping both language areas in one experiment.

journal_name

Acta Neuropsychiatr

journal_title

Acta neuropsychiatrica

authors

Berntsen EM,Rasmussen IA,Samuelsen P,Xu J,Haraldseth O,Lagopoulos J,Malhi GS

doi

10.1111/j.1601-5215.2006.00134.x

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

115-9

issue

2

eissn

0924-2708

issn

1601-5215

pii

S0924270800003598

journal_volume

18

pub_type

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