Neuroleptic malignant syndrome: risk factors, pathophysiology, and treatment.

abstract：OBJECTIVES:Mazindol is a sympathomimetic amine, widely used as an anorectic agent in the treatment of obesity. This drug causes psychostimulant effects because of its pharmacological profile similar to amphetamine, acting like a monoamine reuptake inhibitor. However, the mechanisms underlying the action of mazindol are...

journal_title：Acta neuropsychiatrica

authors： Gonçalves CL,Scaini G,Rezin GT,Jeremias IC,Bez GD,Daufenbach JF,Gomes LM,Ferreira GK,Zugno AI,Streck EL

更新日期：2014-06-01 00:00:00

abstract：:Biological schizophrenia research has been dominated by the dopamine hypothesis for decades, but in recent years a more diversified view has gained increasing attention. Several neurotransmitters are now being discussed, and especially their interaction in complex circuitries. The demonstration of an atypical profile ...

journal_title：Acta neuropsychiatrica

authors： Carlsson A

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Studies on the determinants of the quality of life (QOL) after stroke bring differing results depending on the applied concept of QOL. This may lead to confusion about the contribution of various factors to the post-stroke QOL. OBJECTIVE:The aim of the study was: (i) to investigate functional and psychologi...

journal_title：Acta neuropsychiatrica

authors： Jaracz K,Jaracz J,Kozubski W,Rybakowski JK

更新日期：2002-10-01 00:00:00

abstract：:A huge number of natural and synthetic compounds modulate the function of the γ-aminobutyric acid type A receptor (GABAA-R) by interacting with several allosteric binding sites which may differ in the various GABAA-R subtypes. The benzodiazepine receptor (BDZ-R) is the most intensively studied allosteric site. It is t...

journal_title：Acta neuropsychiatrica

authors： Vermeulen PJ,Zitman FG

更新日期：2000-03-01 00:00:00

abstract：:The alterations in the inflammatory response system (IRS) appear to be quite different between OCD and anorexia nervosa and are also different from the changes observed in major depression. In anorexia nervosa, there is some evidence for increased production of monocytic cytokines, i.e. tumor necrosis factor-α (TNFα) ...

journal_title：Acta neuropsychiatrica

authors： van West D,Maes M

更新日期：1999-12-01 00:00:00

abstract：:Several lines of evidence suggest that there may be abnormal brain serotonin metabolism in habitually biolent and impulsive offenders. These personality disorders are usually connected with early onset, male limited type 2 alcoholism in which one central feature is the abnormal tendency to behave aggressively and impu...

journal_title：Acta neuropsychiatrica

authors： Virkkunen MD

更新日期：1990-09-01 00:00:00

abstract：:For more than 20 years, patients with borderline personality disorder have been treated as in-patients in the UC St-Jozef in Kortenberg, Belgium. The majority of these patients were treated in a psychoanalytical or a behavior therapy ward. During these years, the treatment programs of these wards were gradually adjust...

journal_title：Acta neuropsychiatrica

authors： Pieters G,Vermote R

更新日期：2002-04-01 00:00:00

abstract：UNLABELLED:Jones MP, Bartrop RW, Forcier L, Penny R. The long-term impact of bereavement upon spouse health: a 10-year follow-up. OBJECTIVES:This study is the first to examine the effect of bereavement of a first-degree family member on subsequent morbidity over a 10-year follow-up period. METHODS:A sample of bereave...

journal_title：Acta neuropsychiatrica

authors： Jones MP,Bartrop RW,Forcier L,Penny R

更新日期：2010-10-01 00:00:00

abstract：:Depressive syndromes are a group of heterogeneous disorders. Atypical depression (AD) with reversed vegetative signs, such as hyperphagia or hypersomnia, is traditionally neglected, demonstrated by the fact that in the most widely used depression scales, such as the Hamilton Depression Scale (HAMD), melancholic sympto...

journal_title：Acta neuropsychiatrica

authors： Murck H

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Schizophrenia is consistently associated with lower IQ compared to the IQ of control groups, or estimated premorbid IQ. It is not likely that the IQ scores deteriorate during the prodromal phase or first psychotic episode; they are already present before the onset of the prodromal phase and have been detecte...

journal_title：Acta neuropsychiatrica

authors： van Beilen M,Withaar F,van Zomeren AH,van den Bosch R

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Shared decision making (SDM) is an essential component of patient-centered care, but there is little information about its use in the psychiatric care. OBJECTIVE:To measure to what extent psychiatric patients feel they were involved in the process and steps of decision making about treatment choice and to a...

journal_title：Acta neuropsychiatrica

authors： De las Cuevas C,Peñate W

更新日期：2014-12-01 00:00:00

abstract：:Melatonin is a hormone secreted by the pineal gland mainly during the night. The discovery that this melatonin secretion decreases under the influence of bright light, gave rise to the use of light therapy in some affective disorders. The literature on the relationship between melatonin secretion and mood is reviewed ...

journal_title：Acta neuropsychiatrica

authors： Beullens J

更新日期：1995-09-01 00:00:00

abstract：:Over the past 25 years much effort has been put into the research of the relationship between neuropsychiatric disorders and the concentrations of CSF-monoamine metabolites. Most of this research has beenfocused on the relation between CSF-concentrations of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HV...

journal_title：Acta neuropsychiatrica

authors： Verhoeven WM

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Somatization has been defined in a number of ways. Despite their differences, these definitions have one element in common, namely the presence of somatic symptoms that cannot be explained (adequately) by organic findings. OBJECTIVE:The primary objectives of the dissertation were to gain a better insight in...

journal_title：Acta neuropsychiatrica

authors： De Gucht V

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:Stress can stimulate increased production of oxygen radicals. We investigated the correlations between serum levels of lipid peroxidation markers and those in brain samples in different stress models. METHODS:Animals (n = 96) were divided equally into eight groups: a control group and groups treated with vit...

journal_title：Acta neuropsychiatrica

authors： Celikbilek A,Gocmen AY,Tanik N,Yaras N,Yargicoglu P,Gumuslu S

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:To investigate gender differences in psychiatric comorbidity patients diagnosed with attention-deficit hyperactivity disorder (ADHD) as adults. METHODS:Interviews about current ADHD symptoms and psychiatric comorbidity on axis I and II (Structured Clinical Interview for DSM-IV axis I and axis II) were conduc...

journal_title：Acta neuropsychiatrica

authors： Edvinsson D,Lindström E,Bingefors K,Lewander T,Ekselius L

更新日期：2013-06-01 00:00:00

abstract：:Most forms of behaviour whether normal or abnormal, show a tendency to run in families. However, these can range from symptoms of dementia and movement disorder caused by the comparatively rare autosomal dominant Huntington's disease to common everyday aspects of behaviour such as religious persuasion or career choice...

journal_title：Acta neuropsychiatrica

authors： McGuffin P

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVE:The mechanisms involved in the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, especially in the functioning of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) in depressed patients, are not well elucidated. The objective of this study was to conduct a systematic review of art...

journal_title：Acta neuropsychiatrica

authors： Von Werne Baes C,de Carvalho Tofoli SM,Martins CM,Juruena MF

更新日期：2012-02-01 00:00:00

abstract：:Fatigue is a common problem; when chronic and disabling, subjects can be categorized as having chronic fatigue syndrome (CFS). Whilst it is most likely a multifactorial condition of biopsychosocial origin, the nature of the pathophysiological component remains unclear. There has been a wealth of interest in the possib...

journal_title：Acta neuropsychiatrica

authors： Cleare AJ

更新日期：2003-12-01 00:00:00

abstract：:In the training program for residents in psychiatry, scientific education and participation in research projects are relatively underdeveloped. This may result in a gap between recently acquired scientific knowledge and its implementation in clinical practice. Since the start of the residency training in psychiatry in...

journal_title：Acta neuropsychiatrica

authors： Verhoeven WM,Goessens LF,van den Berg YW,Tuinier S

更新日期：1999-03-01 00:00:00

abstract：:A great interindividual variability exists in biological response to drugs. This variability is partly attributable to pharmacodynamic factors (drug - receptor interactions) and partly to pharmacokinetic factors. Drugs can be eliminated from the body by renal clearance, metabolism or both. Although every tissue has so...

journal_title：Acta neuropsychiatrica

authors： Touw DJ

更新日期：1999-06-01 00:00:00

abstract：:The elucidation of sleep regulation is not an easy task. On one side, there is a multitude of solid yet disparate data, on the other side, the topic is tempting for engaging in wild speculation, particularly with respect to the functions of sleep. Models may exert a moderating influence by mediating between the two ex...

journal_title：Acta neuropsychiatrica

authors： Borbély AA

更新日期：1995-06-01 00:00:00

abstract：:Depression is a frequent comorbid disorder of many inflammatory diseases and it is suggested that brain inflammatory processes have a pathogenic role in mood dysregulation. Several immunocompromised patients have been treated with cytokines and long-term treatments have resulted in a variety of neuropsychiatric side-e...

journal_title：Acta neuropsychiatrica

authors： Fekkes D,Van Gool AR

更新日期：2003-02-01 00:00:00

abstract：:Het is al lang bekend dat het optreden van ontwikke-lingsmijlpalen sterk van baby tot baby kan verschillen. Theorieën of modellen die daarentegen een strakke timing, gepaard gaande met geringe individuele verschillen, voor ontwikkelingsverschijnselen postuleren, hebben dan ook een zware bewijslast te torsen. Het model...

journal_title：Acta neuropsychiatrica

authors： van Geert P,de Weerth C

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:Recent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong asso...

journal_title：Acta neuropsychiatrica

authors： Chhabra H,Shivakumar V,Subbanna M,Kalmady SV,Bose A,Agarwal SM,Sreeraj VS,Dinakaran D,Narayanaswamy JC,Debnath M,Venkatasubramanian G

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence of and factors associated with depression and stress with perceived quality of life and the salivary cortisol levels in Community Health Agent (CHA). Materials and Methods Cross-sectional descriptive study of CHAs in Pelotas-RS, Brazil. Data collection, including sociodemographic i...

journal_title：Acta neuropsychiatrica

authors： Knuth BS,Cocco RA,Radtke VA,Medeiros JR,Oses JP,Wiener CD,Jansen K

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Encephalitis due to anti-N-methyl-D-aspartate receptor antibodies (ANMDARE) is the most frequent immune-mediated encephalitis. It is distinguished by the subacute onset of neuropsychiatric symptoms. OBJECTIVE:To evaluate the characteristic neuropsychiatric symptoms and their outcome in patients diagnosed wi...

journal_title：Acta neuropsychiatrica

authors： Restrepo-Martinez M,Ramirez-Bermudez J,Bayliss L,Espinola-Nadurille M

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Recognition memory dysfunction has been frequently reported in schizophrenic populations, and has been linked with the development of delusions and thought disorder. A range of neuropsychological abnormalities have also been documented in the biological asymptomatic relatives of patients with schizophrenia; ...

journal_title：Acta neuropsychiatrica

authors： Edelstyn NM,Drakeford J,Oyebode F,Findlay CD

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:Ginsenosides, biologically-active components of the root of Panax ginseng, have been reported to have therapeutic benefits in a number of disease states including psychiatric conditions such as major depressive disorder. Our objective was to determine if a standardized commercial ginseng extract, G115®, could...

journal_title：Acta neuropsychiatrica

authors： Terstege DJ,MacDonald DS,Tasker RA

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Attention-deficit hyperactivity disorder (ADHD) is a chronic neurobiological disorder with childhood onset and persistence through adolescence and adulthood. ADHD patients frequently show exaggerated emotional responses. The amygdala plays an important role in emotion processing and in the activation of the ...

journal_title：Acta neuropsychiatrica

authors： Tajima-Pozo K,Ruiz-Manrique G,Yus M,Arrazola J,Montañes-Rada F

更新日期：2015-12-01 00:00:00