Effects of acute administration of mazindol on brain energy metabolism in adult mice.

Abstract:

OBJECTIVES:Mazindol is a sympathomimetic amine, widely used as an anorectic agent in the treatment of obesity. This drug causes psychostimulant effects because of its pharmacological profile similar to amphetamine, acting like a monoamine reuptake inhibitor. However, the mechanisms underlying the action of mazindol are still not clearly understood. METHODS:Swiss mice received a single acute administration of mazindol (0.25, 1.25 and 2.5 mg/kg, ip) or saline. After 2 h, the animals were killed by decapitation; the brain was removed and used for the evaluation of activities of mitochondrial respiratory chain complexes, Krebs cycle enzymes and creatine kinase. RESULTS:Acute administration of mazindol decreased complex I activity only in the hippocampus. Complex IV activity was increased in the cerebellum (2.5 mg/kg) and cerebral cortex (0.25 mg/kg). Citrate synthase activity was increased in the cerebellum (1.25 mg/kg) and cerebral cortex (1.25 mg/kg), and creatine kinase activity was increased in the cerebellum (1.25 mg/kg). CONCLUSION:We suggest that the inhibition of complex I in the hippocampus only and activation of complex IV, citrate synthase and creatine kinase occurs because of a stimulus effect of mazindol in the central nervous system, which causes a direct impairment on energy metabolism.

journal_name

Acta Neuropsychiatr

journal_title

Acta neuropsychiatrica

authors

Gonçalves CL,Scaini G,Rezin GT,Jeremias IC,Bez GD,Daufenbach JF,Gomes LM,Ferreira GK,Zugno AI,Streck EL

doi

10.1017/neu.2013.43

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

146-54

issue

3

eissn

0924-2708

issn

1601-5215

pii

S0924270813000434

journal_volume

26

pub_type

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