Serotoninergic findings in habitual violence and impulsivity. A review.

Abstract:

:Several lines of evidence suggest that there may be abnormal brain serotonin metabolism in habitually biolent and impulsive offenders. These personality disorders are usually connected with early onset, male limited type 2 alcoholism in which one central feature is the abnormal tendency to behave aggressively and impulsively under the influence of alcohol repeatedly. Low CSF 5-HIAA has been found to correlate with familial alcoholism tendencies; paternal alcoholism. Both this and with it the tendency to abnormal oral glucose tolerance test (tendency to low blood glucose nadir) predict the new violent and impulsive crimes under the influence of alcohol. Also peripheral measures such as platelet MAO, abnormal tryptophan/LNAA ratio in plasma, whole blood serotonin, blood platelet uptake of serotonin, platelet 3H-IMI dinging (Bmax), abnormal prolactin and Cortisol secretion in fenfluramine challenge, and possibly daily urinary free Cortisol secretion correlate with impulsive aggressive behavior.

journal_name

Acta Neuropsychiatr

journal_title

Acta neuropsychiatrica

authors

Virkkunen MD

doi

10.1017/S0924270800035110

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

66-71

issue

3

eissn

0924-2708

issn

1601-5215

pii

S0924270800035110

journal_volume

2

pub_type

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