Changes in immune and endocrine systems in posttraumatic stress disorder - prospective study.

Abstract:

INTRODUCTION AND AIM:Posttraumatic stress disorder (PTSD) is associated with increased medical morbidity, particularly from the autoimmune and cardiovascular diseases. Changes in the endocrine and immune system are key mediators in this process. The aim of our study was to investigate weather hormones (cortisol and prolactin), proinflammatory cytokines (interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)), components of HPA-axis (lymphocyte expression of glucocorticoid receptor (GR)), immune function (natural killer cell cytotoxicity) and peripheral blood percentages of various lymphocyte subpopulations (T cells, helper T cells, cytotoxic T cells, B cells and natural killer cells) change in patients with posttraumatic stress disorder over time.

journal_name

Acta Neuropsychiatr

journal_title

Acta neuropsychiatrica

authors

Vidović A,Vilibić M,Sabioncello A,Gotovac K,Rabatić S,Folnegović-Šmalc V,Dekaris D

doi

10.1017/S0924270800032725

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

46-50

eissn

0924-2708

issn

1601-5215

pii

S0924270800032725

journal_volume

21 Suppl 2

pub_type

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