当前位置： SCI文献检索 > ACTA NEUROPSYCHIATRICA期刊下所有文献 > Evaluation of energetic metabolism in the rat brain after meningitis induction by Klebsiella pneumoniae.

Evaluation of energetic metabolism in the rat brain after meningitis induction by Klebsiella pneumoniae.

Abstract：

BACKGROUND:Bacterial meningitis is an infection of the central nervous system characterised by strong inflammatory response. The brain is highly dependent on ATP, and the cell energy is obtained through oxidative phosphorylation, a process which requires the action of various respiratory enzyme complexes and creatine kinase (CK) as an effective buffering system of cellular ATP levels in tissues that consume high energy. OBJECTIVES:Evaluate the activities of mitochondrial respiratory chain complexes I, II, III, IV and CK activity in hippocampus and cortex of the Wistar rat submitted to meningitis by Klebsiella pneumoniae. METHODS:Adult Wistar rats received either 10 µl of sterile saline as a placebo or an equivalent volume of K. pneumoniae suspension. The animals were killed in different times at 6, 12, 24 and 48 h after meningitis induction. Another group was treated with antibiotic, starting at 16 h and continuing daily until their decapitation at 24 and 48 h after induction. RESULTS:In the hippocampus, the meningitis group without antibiotic treatment, the complex I was increased at 24 and 48 h, complex II was increased at 48 h, complex III was inhibited at 6, 12, 24 and 48 h and in complex IV all groups with or without antibiotic treatment were inhibited after meningitis induction, in the cortex there was no alteration. Discussion Although descriptive, our results show that antibiotic prevented in part the changes of the mitochondrial respiratory chain. The meningitis model could be a good research tool to study the biological mechanisms involved in the pathophysiology of the K. pneumoniae meningitis.

journal_name

Acta Neuropsychiatr

journal_title

Acta neuropsychiatrica

authors

Barichello T,Simões LR,Generoso JS,Carradore MM,Moreira AP,Panatto AP,Costa CS,Filho AS,Jeremias IC,Bez GD,Streck E

doi

10.1111/j.1601-5215.2012.00671.x

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

95-100

issue

2

eissn

0924-2708

issn

1601-5215

pii

S1601521512000171

journal_volume

25

pub_type

杂志文章

相关文献

ACTA NEUROPSYCHIATRICA文献大全
  • To what extent psychiatric patients feel involved in decision making about their mental health care? Relationships with socio-demographic, clinical, and psychological variables.

    abstract：BACKGROUND:Shared decision making (SDM) is an essential component of patient-centered care, but there is little information about its use in the psychiatric care. OBJECTIVE:To measure to what extent psychiatric patients feel they were involved in the process and steps of decision making about treatment choice and to a...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/neu.2014.21

    authors： De las Cuevas C,Peñate W

    更新日期：2014-12-01 00:00:00

  • The developing role of pharmacogenetics in psychiatry.

    abstract：:A great interindividual variability exists in biological response to drugs. This variability is partly attributable to pharmacodynamic factors (drug - receptor interactions) and partly to pharmacokinetic factors. Drugs can be eliminated from the body by renal clearance, metabolism or both. Although every tissue has so...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/S092427080003622X

    authors： Touw DJ

    更新日期：1999-06-01 00:00:00

  • Neuroticism, alexithymia, negative affect and positive affect as predictors of medically unexplained symptoms in primary care.

    abstract：BACKGROUND:Somatization has been defined in a number of ways. Despite their differences, these definitions have one element in common, namely the presence of somatic symptoms that cannot be explained (adequately) by organic findings. OBJECTIVE:The primary objectives of the dissertation were to gain a better insight in...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1034/j.1601-5215.2002.140404.x

    authors： De Gucht V

    更新日期：2002-08-01 00:00:00

  • Safety, tolerability and efficacy of a rapid dose escalation of quetiapine in bipolar I mania: the FATIMA study.

    abstract：OBJECTIVE:The FATIMA study (FAst TItration of quetiapine fumarate in bipolar I MAnia) evaluated the safety, tolerability and efficacy of a rapid dose escalation of quetiapine in acutely ill bipolar I patients experiencing a manic episode. METHODS:In an open-label, phase II pilot study, 29 patients aged 18 years or old...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1111/j.1601-5215.2009.00378.x

    authors： Constant E,Seghers A,Ranalli E,Ryckmans V,Snauwaert P,Parent M,Vandenhoven G

    更新日期：2009-06-01 00:00:00

  • Gender differences of axis I and II comorbidity in subjects diagnosed with attention-deficit hyperactivity disorder as adults.

    abstract：OBJECTIVE:To investigate gender differences in psychiatric comorbidity patients diagnosed with attention-deficit hyperactivity disorder (ADHD) as adults. METHODS:Interviews about current ADHD symptoms and psychiatric comorbidity on axis I and II (Structured Clinical Interview for DSM-IV axis I and axis II) were conduc...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1111/j.1601-5215.2012.00682.x

    authors： Edvinsson D,Lindström E,Bingefors K,Lewander T,Ekselius L

    更新日期：2013-06-01 00:00:00

  • Electroconvulsive therapy versus transcranial magnetic stimulation for major depression: a review with recommendations for future research.

    abstract：OBJECTIVE:To review the literature comparing electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) for major depression. METHODS:Data from the six randomised, prospective studies were agglutinated into one data set. Special attention was given to the methods of both TMS and ECT as well as data pe...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1111/j.1601-5215.2008.00333.x

    authors： Rasmussen KG

    更新日期：2008-12-01 00:00:00

  • Melatonine en stemmingsstoornissen.

    abstract：:Melatonin is a hormone secreted by the pineal gland mainly during the night. The discovery that this melatonin secretion decreases under the influence of bright light, gave rise to the use of light therapy in some affective disorders. The literature on the relationship between melatonin secretion and mood is reviewed ...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/S0924270800037376

    authors： Beullens J

    更新日期：1995-09-01 00:00:00

  • Immunopathogenesis of multiple sclerosis.

    abstract：:Immunopathogenesis of multiple sclerosis is a complex process involving T cell mediated autoimmunity at initial stage of disease. A long standing view that Th1 cells are critical for early inflammatory development of lesions is challenging by recent findings that Th1 helper cells with Th17 phenotype are even more impo...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/S0924270800032622

    authors： Brinar V

    更新日期：2009-06-01 00:00:00

  • Long chain omega-3 polyunsaturated fatty acids in the treatment of psychiatric illnesses in children and adolescents.

    abstract：OBJECTIVE:Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) are in increasing use in the general population to treat health problems. The objective of the current article is to review the evidence for the rationale and benefit of LCn-3PUFA in the treatment of common psychiatric disorders in children and adoles...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1111/j.1601-5215.2007.00189.x

    authors： Clayton EH,Hanstock TL,Garg ML,Hazell PL

    更新日期：2007-04-01 00:00:00

  • Anxiety and styles of coping with occupational stress resulting from work with 'dangerous' prisoners in prison service officers.

    abstract：OBJECTIVE:Prisoners categorised as 'dangerous' are a category of prisoners that require and/or force into using special measures of caution, protection and security. The aim of the study was to examine the intensity of anxiety (as a state and as a trait) experienced by officers working with 'dangerous' prisoners and st...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/neu.2015.31

    authors： Tsirigotis K,Gruszczyński W,Pęczkowski S

    更新日期：2015-10-01 00:00:00

  • Benzodiazepinen in perspectief (I): De GABAA-benzodiazepine-receptor.

    abstract：:In this first part of a review on recent insights into the structure and function of the γ-aminobuty rie acid type A - benzodiazepine receptor system, the γ-aminobutyric acid type A (GABAA) receptor and the different types of benzodiazepine (BDZ) receptors known at this moment are dicussed. GABAA- and BDZ receptors ar...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/S0924270800037078

    authors： Vermeulen PJ,Zitman FG

    更新日期：1996-09-01 00:00:00

  • A Ventral Prefrontal-Amygdala Neural System in Bipolar Disorder: A View from Neuroimaging Research.

    abstract：:In the past decade, neuroimaging research has identified key components in the neural system that underlies bipolar disorder (BD). The ventral prefrontal cortex (VPFC) and amygdala are highly interconnected structures that jointly play a central role in emotional regulation. Numerous research groups have reported prom...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：

    authors： Womer FY,Kalmar JH,Wang F,Blumberg HP

    更新日期：2009-09-23 00:00:00

  • Serotoninergic findings in habitual violence and impulsivity. A review.

    abstract：:Several lines of evidence suggest that there may be abnormal brain serotonin metabolism in habitually biolent and impulsive offenders. These personality disorders are usually connected with early onset, male limited type 2 alcoholism in which one central feature is the abnormal tendency to behave aggressively and impu...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/S0924270800035110

    authors： Virkkunen MD

    更新日期：1990-09-01 00:00:00

  • Gender differences in socio-demographic, clinical characteristics and psychiatric diagnosis in/of suicide attempters in a Mexican population.

    abstract：OBJECTIVE:The aim of the present study was to analyse demographic and clinical characteristics, as well as psychiatric diagnoses to identify gender differences in patients with attempted suicide in a Mexican population. METHODS:Between September 2010 and September 2012, 140 suicide attempts were documented in the Depa...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/neu.2015.6

    authors： Fresán A,González-Castro TB,Peralta-Jiménez Y,Juárez-Rojop I,Pool-García S,Velázquez-Sánchez MP,López-Narváez L,Tovilla-Zárate CA

    更新日期：2015-06-01 00:00:00

  • Double depression: its morbidity and management in a community setting.

    abstract：BACKGROUND:Double depression, the combination of major depression and dysthymia, is associated with poor health-related quality of life (HRQoL) and increased health service utilization. OBJECTIVE:To determine the prevalence of double depression, its associated morbidity and use of health services and antidepressants. ...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1111/j.1601-5215.2006.00153.x

    authors： Goldney RD,Bain MA

    更新日期：2006-10-01 00:00:00

  • α2-adrenoceptor binding in Flinders-sensitive line compared with Flinders-resistant line and Sprague-Dawley rats.

    abstract：OBJECTIVES:Disturbances in the noradrenergic system, including alterations in the densities of α2-adrenoceptors, are posited to be involved in the pathophysiology of depression. In this study, we investigate the binding of α2-adrenoceptors in regions relevant to depression in an animal model of depression. METHODS:Usi...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/neu.2015.24

    authors： Lillethorup TP,Iversen P,Wegener G,Doudet DJ,Landau AM

    更新日期：2015-12-01 00:00:00

  • Temperament and Character Inventory (TCI) in adolescents with anorexia nervosa.

    abstract：BACKGROUND:Female patients with anorexia nervosa differ significantly from the control women in various dimensions of personality. OBJECTIVE:To investigate the personality dimensions measured with the Temperament and Character Inventory (TCI) in adolescent patients with restrictive-type and bulimic/purging-type anorex...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1111/j.0924-2708.2004.00073.x

    authors： Rybakowski F,Slopien A,Zakrzewska M,Hornowska E,Rajewski A

    更新日期：2004-06-01 00:00:00

  • Cytokines in de obsessief compulsieve stoornis en in anorexia nervosa: een overzicht.

    abstract：:The alterations in the inflammatory response system (IRS) appear to be quite different between OCD and anorexia nervosa and are also different from the changes observed in major depression. In anorexia nervosa, there is some evidence for increased production of monocytic cytokines, i.e. tumor necrosis factor-α (TNFα) ...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/S0924270800035869

    authors： van West D,Maes M

    更新日期：1999-12-01 00:00:00

  • Adjunctive cognitive remediation for schizophrenia using yoga: an open, non-randomized trial.

    abstract：:BACKGROUND: Yoga therapy (YT) improves cognitive function in healthy individuals, but its impact on cognitive function among persons with schizophrenia (SZ) has not been investigated. AIMS: Evaluate adjunctive YT for cognitive domains impaired in SZ. METHODS: Patients with SZ received YT or treatment as usual (TAU; ...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1111/j.1601-5215.2011.00587.x

    authors： Bhatia T,Agarwal A,Shah G,Wood J,Richard J,Gur RE,Gur RC,Nimgaonkar VL,Mazumdar S,Deshpande SN

    更新日期：2012-04-01 00:00:00

  • Sleep quality in schizophrenia and the effects of atypical antipsychotic medication.

    abstract：BACKGROUND:Sleep disorders are widespread among patients with schizophrenia and contribute to adverse clinical outcomes. Antipsychotic drugs exert varying effects on sleep, and the effects of atypical agents may differ from those of conventional neuroleptics. OBJECTIVE:To review the literature on the effects of atypic...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1111/j.0924-2708.2004.00103.x

    authors： Haffmans PM,Oolders HJ,Hoencamp E,Schreiner A

    更新日期：2004-12-01 00:00:00

  • Is CO2 inhalation a specific marker for panic disorder? An experimental panic model.

    abstract：:Patients with panic disorder (PD) report a transient feeling of anxiety upon inhalation of CO2 enriched air. They rate this experience as similar to symptoms of a panic attack. This hypersensitivity has been proposed as an experimental disease model. This paper examines the validity of single breath inhalation of 35% ...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/S0924270800037030

    authors： Griez E

    更新日期：1996-12-01 00:00:00

  • Gene polymorphisms and response to transcranial direct current stimulation for auditory verbal hallucinations in schizophrenia.

    abstract：OBJECTIVE:Recent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong asso...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/neu.2018.4

    authors： Chhabra H,Shivakumar V,Subbanna M,Kalmady SV,Bose A,Agarwal SM,Sreeraj VS,Dinakaran D,Narayanaswamy JC,Debnath M,Venkatasubramanian G

    更新日期：2018-08-01 00:00:00

  • In vitro effect of antipsychotics on brain energy metabolism parameters in the brain of rats.

    abstract：OBJECTIVE:Typical and atypical antipsychotic drugs have been shown to have different clinical, biochemical and behavioural profiles. It is well described that impairment of metabolism, especially in the mitochondria, leads to oxidative stress and neuronal death and has been implicated in the pathogenesis of a number of...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1111/j.1601-5215.2012.00650.x

    authors： Scaini G,Rochi N,Morais MO,Maggi DD,De-Nês BT,Quevedo J,Streck EL

    更新日期：2013-02-01 00:00:00

  • A comprehensive study of oxidative stress in patients with somatic symptom disorder.

    abstract：OBJECTIVE:To investigate oxidative stress parameters [total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase (PON), arylesterase (ARE) and thiol-disulphide homeostasis] in patients who were diagnosed as having somatic symptom disorder in accordance with Diagnostic and Stat...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/neu.2018.33

    authors： Kabadayi Sahin E,Caykoylu A,Senat A,Erel O

    更新日期：2018-12-18 00:00:00

  • Post-stroke quality of life and depression.

    abstract：BACKGROUND:Studies on the determinants of the quality of life (QOL) after stroke bring differing results depending on the applied concept of QOL. This may lead to confusion about the contribution of various factors to the post-stroke QOL. OBJECTIVE:The aim of the study was: (i) to investigate functional and psychologi...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1034/j.1601-5215.2002.140504.x

    authors： Jaracz K,Jaracz J,Kozubski W,Rybakowski JK

    更新日期：2002-10-01 00:00:00

  • Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression.

    abstract：OBJECTIVE:This study aimed to explore effects of adjunctive treatment with N-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar depression. METHODS:This is a secondary analysis of a placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, and week 32 of the open-...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章,随机对照试验

    doi：10.1017/neu.2018.13

    authors： Panizzutti B,Bortolasci C,Hasebe K,Kidnapillai S,Gray L,Walder K,Berk M,Mohebbi M,Dodd S,Gama C,Magalhães PV,Cotton SM,Kapczinski F,Bush AI,Malhi GS,Dean OM

    更新日期：2018-12-01 00:00:00

  • Serum lipid peroxidation markers are correlated with those in brain samples in different stress models.

    abstract：OBJECTIVE:Stress can stimulate increased production of oxygen radicals. We investigated the correlations between serum levels of lipid peroxidation markers and those in brain samples in different stress models. METHODS:Animals (n = 96) were divided equally into eight groups: a control group and groups treated with vit...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/neu.2013.32

    authors： Celikbilek A,Gocmen AY,Tanik N,Yaras N,Yargicoglu P,Gumuslu S

    更新日期：2014-02-01 00:00:00

  • In-patient treatment of borderline personality disorder: convergences and divergences between a psychoanalytical and a cognitive-behavioral approach.

    abstract：:For more than 20 years, patients with borderline personality disorder have been treated as in-patients in the UC St-Jozef in Kortenberg, Belgium. The majority of these patients were treated in a psychoanalytical or a behavior therapy ward. During these years, the treatment programs of these wards were gradually adjust...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1034/j.1601-5215.2002.140206.x

    authors： Pieters G,Vermote R

    更新日期：2002-04-01 00:00:00

  • Neuroleptic malignant syndrome: risk factors, pathophysiology, and treatment.

    abstract：:Neuroleptic malignant syndrome (NMS) is associated with the administration of antipsychotic agents and other drugs such as l-dopa, antidepressants, and antihistaminic agents. Unexpected changes in mental status, new-onset catatonia, episodic tachycardia, tachypnea, hypertension, dysarthria, dysphagia, diaphoresis, sia...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1111/j.0924-2708.2004.00085.x

    authors： Ananth J,Aduri K,Parameswaran S,Gunatilake S

    更新日期：2004-08-01 00:00:00

  • Changes in immune and endocrine systems in posttraumatic stress disorder - prospective study.

    abstract：INTRODUCTION AND AIM:Posttraumatic stress disorder (PTSD) is associated with increased medical morbidity, particularly from the autoimmune and cardiovascular diseases. Changes in the endocrine and immune system are key mediators in this process. The aim of our study was to investigate weather hormones (cortisol and pro...

    journal_title：Acta neuropsychiatrica

    pub_type： 杂志文章

    doi：10.1017/S0924270800032725

    authors： Vidović A,Vilibić M,Sabioncello A,Gotovac K,Rabatić S,Folnegović-Šmalc V,Dekaris D

    更新日期：2009-06-01 00:00:00