The role of serotonin in panic: evidence from tryptophan depletion studies.

Abstract:

:There has been growing interest in the role of serotonin (5-hydroxytryptamine, 5-HT) in anxiety, including pathological states such as panic disorder. The technique of tryptophan depletion (TD), which causes an acute, temporary and reversible reduction in brain 5-HT levels, is a useful minimally invasive paradigm to aid the research of the role of 5-HT in various disorders. This review discusses the evidence supporting the hypothesis that 5-HT function is of importance in the neurobiology of panic disorder and considers in more detail how our understanding has been influenced by work using the technique of TD. Possible avenues for future research are also discussed.

journal_name

Acta Neuropsychiatr

journal_title

Acta neuropsychiatrica

authors

Pyle AC,Argyropoulos SV,Nutt DJ

doi

10.1111/j.0924-2708.2004.0081.x

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

79-84

issue

2

eissn

0924-2708

issn

1601-5215

pii

S0924270800004075

journal_volume

16

pub_type

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