Abstract:
:BACKGROUND: Aberrant electrophysiological and hemodynamic processing of auditory oddball stimuli is among the most robustly documented findings in patients with schizophrenia. However, no study to date has directly examined linked patterns of electrical and hemodynamic differences in patients and controls. METHODS: In a recent paper we demonstrated a data-driven approach, joint independent component analysis (jICA) to fuse together functional magnetic resonance imaging (fMRI) and event-related potential (ERP) data and elucidated the chronometry of auditory oddball target detection in healthy control subjects. In this paper we extend our fusion method to identify specific differences in the neuronal chronometry of target detection for chronic schizophrenia patients compared to healthy controls. RESULTS: We found one linked source, consistent with the N2 response, known to be related to cognitive processing of deviant stimuli, spatially localized to bilateral fronto-temporal regions. This source showed significant between-group differences both in amplitude response and in the fMRI/ERP distribution pattern. These findings are consistent with previous work showing N2 amplitude and latency abnormalities in schizophrenia, and provide new information about the linkage between the two. CONCLUSIONS: In summary, we use a novel approach to isolate and identify a linked fMRI/ERP component which shows marked differences in chronic schizophrenia patients. We also demonstrate that jointly using both fMRI and ERP measures provides a fully picture of the underlying hemodynamic and electrical changes which are present in patients. Our approach also has broad applicability to other diseases such as autism, Alzheimer's disease, or bipolar disorder.
journal_name
Acta Neuropsychiatrjournal_title
Acta neuropsychiatricaauthors
Calhoun V,Wu L,Kiehl K,Eichele T,Pearlson Gdoi
10.1111/j.1601-5215.2010.00467.xsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
127-138issue
3eissn
0924-2708issn
1601-5215journal_volume
22pub_type
杂志文章abstract::Most forms of behaviour whether normal or abnormal, show a tendency to run in families. However, these can range from symptoms of dementia and movement disorder caused by the comparatively rare autosomal dominant Huntington's disease to common everyday aspects of behaviour such as religious persuasion or career choice...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800036127
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:To observe spike activity in electroencephalograms (EEGs), patients with symptomatic partial epilepsy are rarely monitored during the hyperventilation stages. CASE:A 38-year-old woman suffered from a ruptured arteriovenous malformation in the left temporal lobe. One and a half years later, the patient exper...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2007.00167.x
更新日期:2007-02-01 00:00:00
abstract::Several lines of evidence suggest that there may be abnormal brain serotonin metabolism in habitually biolent and impulsive offenders. These personality disorders are usually connected with early onset, male limited type 2 alcoholism in which one central feature is the abnormal tendency to behave aggressively and impu...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800035110
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVE:Stress can stimulate increased production of oxygen radicals. We investigated the correlations between serum levels of lipid peroxidation markers and those in brain samples in different stress models. METHODS:Animals (n = 96) were divided equally into eight groups: a control group and groups treated with vit...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2013.32
更新日期:2014-02-01 00:00:00
abstract:UNLABELLED:Jones MP, Bartrop RW, Forcier L, Penny R. The long-term impact of bereavement upon spouse health: a 10-year follow-up. OBJECTIVES:This study is the first to examine the effect of bereavement of a first-degree family member on subsequent morbidity over a 10-year follow-up period. METHODS:A sample of bereave...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2010.00482.x
更新日期:2010-10-01 00:00:00
abstract::For more than 20 years, patients with borderline personality disorder have been treated as in-patients in the UC St-Jozef in Kortenberg, Belgium. The majority of these patients were treated in a psychoanalytical or a behavior therapy ward. During these years, the treatment programs of these wards were gradually adjust...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1034/j.1601-5215.2002.140206.x
更新日期:2002-04-01 00:00:00
abstract::In this first part of a review on recent insights into the structure and function of the γ-aminobuty rie acid type A - benzodiazepine receptor system, the γ-aminobutyric acid type A (GABAA) receptor and the different types of benzodiazepine (BDZ) receptors known at this moment are dicussed. GABAA- and BDZ receptors ar...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800037078
更新日期:1996-09-01 00:00:00
abstract::Depressive syndromes are a group of heterogeneous disorders. Atypical depression (AD) with reversed vegetative signs, such as hyperphagia or hypersomnia, is traditionally neglected, demonstrated by the fact that in the most widely used depression scales, such as the Hamilton Depression Scale (HAMD), melancholic sympto...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1034/j.1601-5215.2003.00029.x
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Recognition memory dysfunction has been frequently reported in schizophrenic populations, and has been linked with the development of delusions and thought disorder. A range of neuropsychological abnormalities have also been documented in the biological asymptomatic relatives of patients with schizophrenia; ...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1034/j.1601-5215.2003.00044.x
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Schizophrenia is consistently associated with lower IQ compared to the IQ of control groups, or estimated premorbid IQ. It is not likely that the IQ scores deteriorate during the prodromal phase or first psychotic episode; they are already present before the onset of the prodromal phase and have been detecte...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1034/j.1601-5215.2002.140302.x
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Previous studies suggest that brain serotonin neurotransmission may mediate the actions of lithium carbonate. Acute tryptophan depletion (ATD) reduces brain serotonin and allows the study of this neurotransmitter in patient groups. Serotonin modulates electroencephalographic (EEG) activity, which is abnormal...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800035481
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:Schizoaffective disorder is a disease with both affective and psychotic symptoms. In this study, we aimed to compare oxidative metabolism markers of schizoaffective disorder, bipolar disorder and schizophrenic patients. Furthermore, we also aimed to investigate whether schizoaffective disorder could be differ...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2013.44
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:To investigate how individuals with a history of affective disorder use and perceive their use of social media and online dating. METHODS:A questionnaire focusing on affective disorders and the use of social media and online dating was handed out to outpatients from unipolar depression and bipolar disorder ...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2020.36
更新日期:2020-10-15 00:00:00
abstract::Immunopathogenesis of multiple sclerosis is a complex process involving T cell mediated autoimmunity at initial stage of disease. A long standing view that Th1 cells are critical for early inflammatory development of lesions is challenging by recent findings that Th1 helper cells with Th17 phenotype are even more impo...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800032622
更新日期:2009-06-01 00:00:00
abstract::Over the past 25 years much effort has been put into the research of the relationship between neuropsychiatric disorders and the concentrations of CSF-monoamine metabolites. Most of this research has beenfocused on the relation between CSF-concentrations of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HV...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800034785
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:Recent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong asso...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2018.4
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Despite various studies, supportive evidence for the efficacy of exercise in treatment of mental illness is still weak. OBJECTIVE:The aim of this study was to compare two forms of exercise, namely running therapy (RT) and physiotraining therapy (PT), on stationary devices. METHODS:Patients in a day treatme...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2006.00115.x
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) are in increasing use in the general population to treat health problems. The objective of the current article is to review the evidence for the rationale and benefit of LCn-3PUFA in the treatment of common psychiatric disorders in children and adoles...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2007.00189.x
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:Inverse relationships between the C-reactive protein (CRP) levels and cognitive performance in acute psychosis have been demonstrated. We aimed to investigate how the serum level and initial change of CRP in acutely admitted patients with psychosis was correlated with cognitive performance during a 6-months f...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2018.25
更新日期:2019-02-01 00:00:00
abstract::A psychofysiological study of the cardiac adaptivity to attention-demanding reaction time tasks demonstrated that children with a lesser variant of the pervasive developmental disorder (DSM-IV: PDDNOS) exhibit less cardiac responsiveness to attention tasks than healthy children do. We studied changes in heart rate var...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S092427080003605X
更新日期:1999-09-01 00:00:00
abstract::In the past decade, neuroimaging research has identified key components in the neural system that underlies bipolar disorder (BD). The ventral prefrontal cortex (VPFC) and amygdala are highly interconnected structures that jointly play a central role in emotional regulation. Numerous research groups have reported prom...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:
更新日期:2009-09-23 00:00:00
abstract::A great interindividual variability exists in biological response to drugs. This variability is partly attributable to pharmacodynamic factors (drug - receptor interactions) and partly to pharmacokinetic factors. Drugs can be eliminated from the body by renal clearance, metabolism or both. Although every tissue has so...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S092427080003622X
更新日期:1999-06-01 00:00:00
abstract::In two previous letters on an selective serotonin reuptake inhibitor (SSRI) meta-analysis conducted by the Copenhagen Trial Unit at Copenhagen University Hospital, we have commented on a large number of errors, almost all of which have tilted the results in an anti-drug direction, that unfortunately mar this publicati...
journal_title:Acta neuropsychiatrica
pub_type: 评论,杂志文章
doi:10.1017/neu.2019.42
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:To investigate oxidative stress parameters [total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase (PON), arylesterase (ARE) and thiol-disulphide homeostasis] in patients who were diagnosed as having somatic symptom disorder in accordance with Diagnostic and Stat...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/neu.2018.33
更新日期:2018-12-18 00:00:00
abstract::Neuroleptic malignant syndrome (NMS) is associated with the administration of antipsychotic agents and other drugs such as l-dopa, antidepressants, and antihistaminic agents. Unexpected changes in mental status, new-onset catatonia, episodic tachycardia, tachypnea, hypertension, dysarthria, dysphagia, diaphoresis, sia...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.0924-2708.2004.00085.x
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Bacterial meningitis is an infection of the central nervous system characterised by strong inflammatory response. The brain is highly dependent on ATP, and the cell energy is obtained through oxidative phosphorylation, a process which requires the action of various respiratory enzyme complexes and creatine k...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2012.00671.x
更新日期:2013-04-01 00:00:00
abstract::In the past decade, neuroimaging research has identified key components in the neural system that underlies bipolar disorder (BD). The ventral prefrontal cortex (VPFC) and amygdala are highly interconnected structures that jointly play a central role in emotional regulation. Numerous research groups have reported prom...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1111/j.1601-5215.2009.00414.x
更新日期:2009-10-01 00:00:00
abstract::Fatigue is a common problem; when chronic and disabling, subjects can be categorized as having chronic fatigue syndrome (CFS). Whilst it is most likely a multifactorial condition of biopsychosocial origin, the nature of the pathophysiological component remains unclear. There has been a wealth of interest in the possib...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1046/j.1601-5215.2003.00050.x
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:Somatization has been defined in a number of ways. Despite their differences, these definitions have one element in common, namely the presence of somatic symptoms that cannot be explained (adequately) by organic findings. OBJECTIVE:The primary objectives of the dissertation were to gain a better insight in...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1034/j.1601-5215.2002.140404.x
更新日期:2002-08-01 00:00:00
abstract:INTRODUCTION AND AIM:Posttraumatic stress disorder (PTSD) is associated with increased medical morbidity, particularly from the autoimmune and cardiovascular diseases. Changes in the endocrine and immune system are key mediators in this process. The aim of our study was to investigate weather hormones (cortisol and pro...
journal_title:Acta neuropsychiatrica
pub_type: 杂志文章
doi:10.1017/S0924270800032725
更新日期:2009-06-01 00:00:00