Abstract：
:Depression is a frequent comorbid disorder of many inflammatory diseases and it is suggested that brain inflammatory processes have a pathogenic role in mood dysregulation. Several immunocompromised patients have been treated with cytokines and long-term treatments have resulted in a variety of neuropsychiatric side-effects. The objective of the study was to present evidence for an association between the induction of neuropsychiatric side-effects during treatment with interferon-α (IFN-α) and changes in serotonergic and immunological parameters. Moreover, the use of IFN-α-induced depression as a paradigm for research into the pathophysiology of depressive disorders in general will be discussed. This literature review focused on the relationships between tryptophan, serotonin, cytokines and depression associated with interferon treatment. Immunotherapy with IFN-α influences several immunological and serotonergic parameters, and induces in most patients neurovegetative, somatic and depressive symptoms. Literature findings indicate that the development of depressive symptoms in patients undergoing cytokine therapy are secondary to cytokine induction and could be mediated by a reduced availability of tryptophan to the brain, resulting ultimately in decreased serotonergic activity. Changes in the metabolism of tryptophan and consequently of serotonin may play a role in the pathophysiology of interferon-induced depression. Studies on interferon-induced neuropsychiatric side-effects may be a promising research paradigm and shed light on the role of immunological and serotonergic factors in the pathogenesis of depressive disorders in general. However, first the appropriate symptomatology of the interferon-induced depressive states has to be documented.
journal_name
Acta Neuropsychiatrjournal_title
Acta neuropsychiatricaauthors
Fekkes D,Van Gool ARdoi
10.1034/j.1601-5215.2003.00007.xsubject
Has Abstractpub_date
2003-02-01 00:00:00pages
8-14issue
1eissn
0924-2708issn
1601-5215pii
S0924270800004695journal_volume
15pub_type
杂志文章abstract：OBJECTIVE:This study used a prospective design and the technique of structural modelling to examine the complex interrelations between psychological factors, immune status and complications after major surgery. METHODS:Twenty-nine women scheduled for elective cholecystectomy were studied prospectively. Information reg...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2009.00398.x
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVE:The FATIMA study (FAst TItration of quetiapine fumarate in bipolar I MAnia) evaluated the safety, tolerability and efficacy of a rapid dose escalation of quetiapine in acutely ill bipolar I patients experiencing a manic episode. METHODS:In an open-label, phase II pilot study, 29 patients aged 18 years or old...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2009.00378.x
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Studies on the determinants of the quality of life (QOL) after stroke bring differing results depending on the applied concept of QOL. This may lead to confusion about the contribution of various factors to the post-stroke QOL. OBJECTIVE:The aim of the study was: (i) to investigate functional and psychologi...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1034/j.1601-5215.2002.140504.x
更新日期：2002-10-01 00:00:00
abstract：OBJECTIVE:The mechanisms involved in the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, especially in the functioning of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) in depressed patients, are not well elucidated. The objective of this study was to conduct a systematic review of art...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2011.00610.x
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:Typical and atypical antipsychotic drugs have been shown to have different clinical, biochemical and behavioural profiles. It is well described that impairment of metabolism, especially in the mitochondria, leads to oxidative stress and neuronal death and has been implicated in the pathogenesis of a number of...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2012.00650.x
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Despite various studies, supportive evidence for the efficacy of exercise in treatment of mental illness is still weak. OBJECTIVE:The aim of this study was to compare two forms of exercise, namely running therapy (RT) and physiotraining therapy (PT), on stationary devices. METHODS:Patients in a day treatme...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2006.00115.x
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVE:Pain perception is reported to be altered in patients with depression and schizophrenia. However, few studies have investigated the pain perception in patients with bipolar disorders. We therefore aimed to compare pain sensitivity between patients with bipolar disorder, schizophrenia and controls. METHODS:St...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2007.00193.x
更新日期：2007-10-01 00:00:00
abstract：:The elucidation of sleep regulation is not an easy task. On one side, there is a multitude of solid yet disparate data, on the other side, the topic is tempting for engaging in wild speculation, particularly with respect to the functions of sleep. Models may exert a moderating influence by mediating between the two ex...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1017/S0924270800037443
更新日期：1995-06-01 00:00:00
abstract：:Depressive syndromes are a group of heterogeneous disorders. Atypical depression (AD) with reversed vegetative signs, such as hyperphagia or hypersomnia, is traditionally neglected, demonstrated by the fact that in the most widely used depression scales, such as the Hamilton Depression Scale (HAMD), melancholic sympto...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1034/j.1601-5215.2003.00029.x
更新日期：2003-08-01 00:00:00
abstract：OBJECTIVE:Psychometric research in the field of alcohol dependence has concentrated on identifying certain (personality) characteristics (i.e. typologies). This paper is aimed to identify such typologies and studies the relation of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) and Cloninger's temperament-c...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2007.00188.x
更新日期：2007-08-01 00:00:00
abstract：UNLABELLED:Jones MP, Bartrop RW, Forcier L, Penny R. The long-term impact of bereavement upon spouse health: a 10-year follow-up. OBJECTIVES:This study is the first to examine the effect of bereavement of a first-degree family member on subsequent morbidity over a 10-year follow-up period. METHODS:A sample of bereave...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2010.00482.x
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the involvement of nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome in schizophrenia-like behaviour in young animals exposed to maternal immune activation (MIA). METHODS:To this aim, on the 15th gestational day, the females received an injection of lipopolysaccharides. Whe...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1017/neu.2020.27
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Female patients with anorexia nervosa differ significantly from the control women in various dimensions of personality. OBJECTIVE:To investigate the personality dimensions measured with the Temperament and Character Inventory (TCI) in adolescent patients with restrictive-type and bulimic/purging-type anorex...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.0924-2708.2004.00073.x
更新日期：2004-06-01 00:00:00
abstract：:Fatigue is a common problem; when chronic and disabling, subjects can be categorized as having chronic fatigue syndrome (CFS). Whilst it is most likely a multifactorial condition of biopsychosocial origin, the nature of the pathophysiological component remains unclear. There has been a wealth of interest in the possib...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1046/j.1601-5215.2003.00050.x
更新日期：2003-12-01 00:00:00
abstract：:BACKGROUND: Aberrant electrophysiological and hemodynamic processing of auditory oddball stimuli is among the most robustly documented findings in patients with schizophrenia. However, no study to date has directly examined linked patterns of electrical and hemodynamic differences in patients and controls. METHODS: I...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2010.00467.x
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:The aims of this study were to determine the dominant affective temperament changes in stroke survivors and whether temperament affects the disability. METHODS:A total of 63 stroke patients were included in this study. Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire was used to...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2008.00335.x
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:ConstaTRE is an open-label, randomised, controlled, relapse prevention trial in patients with stable schizophrenia or schizoaffective disorder switched to risperidone long-acting injectable (RLAI) or oral quetiapine, and was designed to test the hypothesis that injectable antipsychotic treatment with risperid...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1017/neu.2013.7
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:The aim of the present study was to analyse demographic and clinical characteristics, as well as psychiatric diagnoses to identify gender differences in patients with attempted suicide in a Mexican population. METHODS:Between September 2010 and September 2012, 140 suicide attempts were documented in the Depa...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1017/neu.2015.6
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:There is clear evidence of a genetic component in major depression, and several studies indicate that neuropeptide Y (NPY) could play an important role in the pathophysiology of the disease. A well-known polymorphism encoding the substitution of leucine to proline in the signal peptide sequence of NPY (Leu7Pr...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2011.00600.x
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:The differentiation between a 'non-organic' depressive episode and an organic depressive disorder on the basis of clinical grounds might be challenging. METHODS:We report a case with an initially typical severe depressive episode without any focal neurological deficits. RESULTS:Only medical history from a t...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1017/neu.2013.19
更新日期：2013-08-01 00:00:00
abstract：:BACKGROUND: Yoga therapy (YT) improves cognitive function in healthy individuals, but its impact on cognitive function among persons with schizophrenia (SZ) has not been investigated. AIMS: Evaluate adjunctive YT for cognitive domains impaired in SZ. METHODS: Patients with SZ received YT or treatment as usual (TAU; ...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2011.00587.x
更新日期：2012-04-01 00:00:00
abstract：:Immunopathogenesis of multiple sclerosis is a complex process involving T cell mediated autoimmunity at initial stage of disease. A long standing view that Th1 cells are critical for early inflammatory development of lesions is challenging by recent findings that Th1 helper cells with Th17 phenotype are even more impo...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1017/S0924270800032622
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Sleep disorders are widespread among patients with schizophrenia and contribute to adverse clinical outcomes. Antipsychotic drugs exert varying effects on sleep, and the effects of atypical agents may differ from those of conventional neuroleptics. OBJECTIVE:To review the literature on the effects of atypic...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.0924-2708.2004.00103.x
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVE:To investigate gender differences in psychiatric comorbidity patients diagnosed with attention-deficit hyperactivity disorder (ADHD) as adults. METHODS:Interviews about current ADHD symptoms and psychiatric comorbidity on axis I and II (Structured Clinical Interview for DSM-IV axis I and axis II) were conduc...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.1601-5215.2012.00682.x
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Shared decision making (SDM) is an essential component of patient-centered care, but there is little information about its use in the psychiatric care. OBJECTIVE:To measure to what extent psychiatric patients feel they were involved in the process and steps of decision making about treatment choice and to a...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1017/neu.2014.21
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:To investigate oxidative stress parameters [total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase (PON), arylesterase (ARE) and thiol-disulphide homeostasis] in patients who were diagnosed as having somatic symptom disorder in accordance with Diagnostic and Stat...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1017/neu.2018.33
更新日期：2018-12-18 00:00:00
abstract：:There has been growing interest in the role of serotonin (5-hydroxytryptamine, 5-HT) in anxiety, including pathological states such as panic disorder. The technique of tryptophan depletion (TD), which causes an acute, temporary and reversible reduction in brain 5-HT levels, is a useful minimally invasive paradigm to a...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1111/j.0924-2708.2004.0081.x
更新日期：2004-04-01 00:00:00
abstract：BACKGROUND:Previous studies suggest that brain serotonin neurotransmission may mediate the actions of lithium carbonate. Acute tryptophan depletion (ATD) reduces brain serotonin and allows the study of this neurotransmitter in patient groups. Serotonin modulates electroencephalographic (EEG) activity, which is abnormal...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1017/S0924270800035481
更新日期：2000-09-01 00:00:00
abstract：:Objective This study explored the utility of the Health Belief Models (HBM) in explaining medication adherence in subjects with severe affective disorders. Method Well established measuring instruments, with confirmed reliability and validity, were used to assess each component of two HBMs and adherence with mood stab...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1017/S0924270800035584
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of and factors associated with depression and stress with perceived quality of life and the salivary cortisol levels in Community Health Agent (CHA). Materials and Methods Cross-sectional descriptive study of CHAs in Pelotas-RS, Brazil. Data collection, including sociodemographic i...
journal_title：Acta neuropsychiatrica
pub_type： 杂志文章
doi：10.1017/neu.2015.58
更新日期：2016-06-01 00:00:00
