Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression.

Abstract:

OBJECTIVE:This study aimed to explore effects of adjunctive treatment with N-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar depression. METHODS:This is a secondary analysis of a placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, and week 32 of the open-label and maintenance phases of the clinical trial to determine changes in interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-α (TNF-α), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following adjunctive NAC treatment, and to explore mediation and moderator effects of the listed markers. RESULTS:Levels of brain-derived neurotrophic factor (BDNF), tumour necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukins (IL) -6, 8, or 10 were not significantly changed during the course of the trial or specifically in the open-label and maintenance phases. There were no mediation or moderation effects of the biological factors on the clinical parameters. CONCLUSION:The results suggest that these particular biological parameters may not be directly involved in the therapeutic mechanism of action of adjunctive NAC in bipolar depression.

journal_name

Acta Neuropsychiatr

journal_title

Acta neuropsychiatrica

authors

Panizzutti B,Bortolasci C,Hasebe K,Kidnapillai S,Gray L,Walder K,Berk M,Mohebbi M,Dodd S,Gama C,Magalhães PV,Cotton SM,Kapczinski F,Bush AI,Malhi GS,Dean OM

doi

10.1017/neu.2018.13

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

334-341

issue

6

eissn

0924-2708

issn

1601-5215

pii

S0924270818000133

journal_volume

30

pub_type

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