Abstract:
PURPOSE OF REVIEW:The goal of the review is to summarize the current knowledge on the process of chondrocyte-to-osteoblast transdifferentiation during endochondral bone formation and its potential implications in fracture healing and disease. RECENT FINDINGS:Lineage tracing experiments confirmed the transdifferentiation of chondrocytes into osteoblasts. More recent studies lead to the discovery of molecules involved in this process, as well as to the hypothesis that these cells may re-enter a stem cell-like phase prior to their osteoblastic differentiation. This review recapitulates the current knowledge regarding chondrocyte transdifferentiating into osteoblasts, the developmental and postnatal events where transdifferentiation appears to be relevant, and the molecules implicated in this process.
journal_name
Curr Osteoporos Repjournal_title
Current osteoporosis reportsauthors
Wolff LI,Hartmann Cdoi
10.1007/s11914-019-00511-3subject
Has Abstractpub_date
2019-06-01 00:00:00pages
129-137issue
3eissn
1544-1873issn
1544-2241pii
10.1007/s11914-019-00511-3journal_volume
17pub_type
杂志文章,评审abstract::Substantial evidence exists that in addition to the well-known complications of diabetes, increased fracture risk is an important morbidity. This risk is probably due, at least in part, to altered bone remodeling and bone cell function in diabetes. Circulating biochemical markers of bone formation, including P1NP, ost...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-015-0265-0
更新日期:2015-06-01 00:00:00
abstract::Low vitamin D status, which is endemic due to inadequate oral intake combined with sun avoidance, contributes to musculoskeletal and other pathologies. Although controversial, it is increasingly recommended that serum 25-hydroxyvitamin D (25D) concentrations less than 30 ng/mL be considered suboptimal. Clinicians shou...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-008-0017-5
更新日期:2008-09-01 00:00:00
abstract::Osteoporosis in men is an unrecognized but growing problem as the number of men who live to old age increases. The 10-year fracture risk at age 50 quadruples by age 80, and in general the incidence rate of osteoporotic fracture in men is about half that of women. Of note, the mortality and morbidity after hip fracture...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-996-0030-5
更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Osteogenesis is a complex process involving the specification of multiple progenitor cells and their maturation and differentiation into matrix-secreting osteoblasts. Osteogenesis occurs not only during embryogenesis but also during growth, after an injury, and in normal homeostatic maintenance. While...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-017-0379-7
更新日期:2017-08-01 00:00:00
abstract::Many orthobiologic adjuvants are available and widely utilized for general skeletal restoration. Their use for the specific task of osteoporotic fracture augmentation is less well recognized. Common conductive materials are reviewed for their value in this patient population including the large group of allograft adju...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-014-0249-5
更新日期:2015-02-01 00:00:00
abstract::A prior fracture is a well-documented risk factor for a subsequent fracture and it doubles the risk of subsequent fractures. Few studies have investigated the time that elapses between the initial and subsequent fracture. These studies show that the subsequent fracture risk is not constant, but fluctuates over time. T...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-010-0023-2
更新日期:2010-09-01 00:00:00
abstract::Establishing a Fracture Liaison Service (FLS) to identify and treat patients with a recent fragility fracture has been shown to be effective, save money, useful to document high quality of care, and makes good clinical sense. A FLS starts with an osteoporosis champion and encompasses identification of patients with a ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-013-0177-9
更新日期:2013-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to explore the role of monocyte chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone remodelling, particularly the action of osteoblasts and osteoclasts, and its role in the development and metastasis of cancers that target the bone. RECENT FINDI...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-019-00545-7
更新日期:2019-12-01 00:00:00
abstract::Microbial biofilms have been observed and described in bone specimens of patients with bisphosphonate (BP)-associated osteonecrosis of the jaw (BONJ) and investigators are more recently suggesting that this condition essentially represents an osteomyelitis of the jaw clinically, with greater susceptibility in some pat...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-010-0008-1
更新日期:2010-03-01 00:00:00
abstract::Osteoporosis is characterized by the occurrence of a host of fractures. According to densitometric values, an operational definition for osteoporosis corresponds to a loss of 25% to 30% (-2.5 T-scores) compared with the mean values of bone mineral density of young premenopausal women. For years, research tried to deve...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-010-0024-1
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL), and has emerged as an important novel therapy for skeletal disorders. This article examines the use of denosumab in children. RECENT FINDINGS:Considerable safety and efficacy data exists for denosumab treatment ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-017-0380-1
更新日期:2017-08-01 00:00:00
abstract::Because there are now effective agents for treatment of osteoporosis, the question is being raised as to whether or not it is ethical to have placebo-controlled trials of new agents. It is ethical for patients who are at low risk of serious or irreversible harm to participate in placebo-controlled trials as long as th...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-004-0012-4
更新日期:2004-03-01 00:00:00
abstract::There is an increasing repertoire of laboratory tests available for assessing the bone remodeling process. Biochemical markers of bone remodeling can be measured in serum or urine, and have a number of potential roles in the management of fracture risk. Differences in remodeling between individuals might be related to...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-996-0002-9
更新日期:2003-12-01 00:00:00
abstract::Vitamin D, acting through its active metabolite 1,25(OH)(2)D(3), exerts its influence on many physiologic processes in addition to the regulation of calcium and phosphate homeostasis. These processes include the immune system. Both the adaptive and innate immune systems are affected by 1,25(OH)(2)D(3) and its receptor...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-009-0011-6
更新日期:2009-07-01 00:00:00
abstract::Intercellular communication within the bone microenvironment is critical for the maintenance of normal bone structure. Osteoblast-lineage cells at all stages of differentiation, from pluripotent precursors to matrix-embedded osteocytes, produce regulatory factors that modulate the differentiation and activity of both ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-012-0096-1
更新日期:2012-06-01 00:00:00
abstract::Caloric restriction caused by undernutrition or over-exercise is increasingly common and has significant health consequences such as hypothalamic amenorrhea, infertility, attainment of low peak bone mass, and bone loss leading to fracture. In these patients, the pathophysiology of amenorrhea and bone loss is multifact...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-007-0011-3
更新日期:2007-12-01 00:00:00
abstract::Atraumatic fractures of the skeleton in osteoporotic patients are directly related to a deterioration of bone strength. However, the failure of the bone tissue to withstand functional load bearing cannot be explained as a simple decrease in bone mineral density (quantity); strength is also significantly dependent upon...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-003-0003-x
更新日期:2003-06-01 00:00:00
abstract::Osteocytes, the most abundant cell type in bone, remain the least characterized. Several theories have been proposed regarding their function, including osteolysis, sensing the strains produced in response to mechanical loading of bones, and producing signals that affect the function of osteoblasts and osteoclasts and...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-007-0007-z
更新日期:2007-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize reports published since the 2013 American Society of Bone and Mineral Research Task Force Report on atypical femoral fractures (AFF). RECENT FINDINGS:The absolute incidence of AFFs remains low. AFFs are primarily associated with prolonged bisphosphonate (BP) exposure, but have also been ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-018-0464-6
更新日期:2018-08-01 00:00:00
abstract::Nutritional status is an essential component in determining whole body energy homeostasis. The balance between energy/food intake and metabolism is governed by a range of hormones secreted from various parts of the body. Their subsequent dissemination via the blood results in a wide range of biological responses inclu...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-013-0157-0
更新日期:2013-09-01 00:00:00
abstract::Microcrack accumulation in cortical bone has been implicated in skeletal fragility and stress fractures. These cracks have also been shown to affect the mechanical and material properties of cortical bone. Their growth has been linked to osteocyte apoptosis and the initiation of the remodeling process, which also has ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-005-0002-1
更新日期:2005-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The goal of this paper is to review state-of-the-art transcriptome profiling methods and their recent applications in the field of skeletal biology. RECENT FINDINGS:Next-generation sequencing of mRNA (RNA-seq) methods have been established and routinely used in skeletal biology research. RNA-seq has ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-019-00517-x
更新日期:2019-08-01 00:00:00
abstract::The postmenopausal state is the most common underlying cause for osteoporosis and most of our understanding of the condition relates to this group. Recent evidence has suggested that hormone therapy may no longer have the pre-eminent place it once held but the same studies have also confirmed its antifracture efficacy...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-004-0018-y
更新日期:2004-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Fractures of osteoporotic bone in elderly individuals need special attention. This manuscript reviews the current strategies to provide sufficient fracture fixation stability with a particular focus on fractures that frequently occur in elderly individuals with osteoporosis and require full load-beari...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-019-00535-9
更新日期:2019-12-01 00:00:00
abstract::Understanding of osteoclast formation and activation has advanced considerably since the discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem cells express receptor activator of NF-jB ligand (RANKL), which binds to its receptor, RANK, on the surface of osteoclasts and their precursors....
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-007-0024-y
更新日期:2007-09-01 00:00:00
abstract::Osteoporotic fractures result in significant morbidity and mortality. Anabolic agents reverse the negative skeletal balance that characterizes osteoporosis by stimulating osteoblast-dependent bone formation to a greater degree than osteoclast-dependent bone resorption. Parathyroid hormone (PTH) and parathyroid hormone...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-013-0171-2
更新日期:2013-12-01 00:00:00
abstract::The occurrence of a fragility fracture is an opportunity to recognize osteoporosis and begin treatment to reduce the risk of another fracture. However, selecting the treatment may have an impact on the incident fracture and this requires careful consideration of the patient and the treatment choices. There is no conse...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-011-0061-4
更新日期:2011-09-01 00:00:00
abstract::Musculoskeletal diseases are highly prevalent with staggering annual health care costs across the globe. The combined wasting of muscle (sarcopenia) and bone (osteoporosis)-both in normal aging and pathologic states-can lead to vastly compounded risk for fracture in patients. Until now, our therapeutic approach to the...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-014-0204-5
更新日期:2014-06-01 00:00:00
abstract:PURPOSE OF REVIEW:We outline the diverse processes contributing to bone mineralization and bone matrix maturation by describing two mouse models with bone strength defects caused by restricted deletion of the receptor tyrosine kinase ligand EphrinB2. RECENT FINDINGS:Stage-specific EphrinB2 deletion differs in its effe...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-019-00524-y
更新日期:2019-10-01 00:00:00
abstract::Currently, the measurement of areal bone mineral density (aBMD) is used at NASA to evaluate the effects of spaceflight on the skeletal health of astronauts. Notably, there are precipitous declines in aBMD with losses >10 % detected in the hip and spine in some astronauts following a typical 6-month mission in space. H...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-013-0136-5
更新日期:2013-06-01 00:00:00