Abstract：
:Microcrack accumulation in cortical bone has been implicated in skeletal fragility and stress fractures. These cracks have also been shown to affect the mechanical and material properties of cortical bone. Their growth has been linked to osteocyte apoptosis and the initiation of the remodeling process, which also has a role in their repair. Clinically, osteoporosis is diagnosed using dual energy x-ray absorptiometry. However, evidence now indicates that bone mass alone is insufficient to satisfactorily explain the skeletal fragility of osteoporosis and consideration needs to be given to bone quality in the diagnosis and treatment of the disease. Bone quality includes parameters such as trabecular and cortical microarchitecture, morphology, bone turnover, degree of mineralization of the bone matrix, and significantly, the amount of microdamage present in the bone. Current clinical treatments concentrate on the inhibition of osteoclast activity to maintain bone mass in osteoporotic patients. However, these cells have a major role in removing existing microcracks from the bone matrix, and hence the use of bone resorption- inhibiting drugs may lead to insufficient bone repair and therefore an increase in microdamage accumulation and loss of bone quality.
journal_name
Curr Osteoporos Repjournal_title
Current osteoporosis reportsauthors
O'Brien FJ,Brennan O,Kennedy OD,Lee TCdoi
10.1007/s11914-005-0002-1keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
39-45issue
2eissn
1544-1873issn
1544-2241journal_volume
3pub_type
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journal_title：Current osteoporosis reports
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journal_title：Current osteoporosis reports
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
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更新日期：2016-10-01 00:00:00
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journal_title：Current osteoporosis reports
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更新日期：2011-12-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
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更新日期：2019-08-01 00:00:00
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更新日期：2004-03-01 00:00:00
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更新日期：2021-01-07 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
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更新日期：2012-12-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-12-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
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更新日期：2015-08-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
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更新日期：2020-02-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
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更新日期：2013-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-12-01 00:00:00
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更新日期：2017-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-06-01 00:00:00
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更新日期：2016-12-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
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更新日期：2021-01-11 00:00:00
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更新日期：2010-03-01 00:00:00
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更新日期：2017-10-01 00:00:00
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更新日期：2019-06-01 00:00:00
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更新日期：2020-06-01 00:00:00
