When the Nervous System Turns Skeletal Muscles into Bones: How to Solve the Conundrum of Neurogenic Heterotopic Ossification.

abstract：:Frailty is highly prevalent in the elderly, increasing the risk of poor outcomes that include falls, incident disability, hospitalization, and mortality. Thus, a great need exists to characterize the underlying mechanisms and ultimately identify strategies that prevent, delay, and even reverse frailty. Mouse models ca...

journal_title：Current osteoporosis reports

authors： Seldeen KL,Pang M,Troen BR

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Novel therapies for damaged and diseased bone are being developed in a preclinical testing process consisting of in vitro cell experiments followed by in vivo animal studies. The in vitro results are often not representative of the results observed in vivo. This could be caused by the complexity of th...

journal_title：Current osteoporosis reports

authors： Cramer EEA,Ito K,Hofmann S

更新日期：2021-01-11 00:00:00

abstract：PURPOSE OF REVIEW:Authors review the safety and efficacy of romosozumab for the treatment of osteoporosis as demonstrated in three phase III clinical trials and offer insights into the potential cardiovascular risk associated with its use. RECENT FINDINGS:Incidence of new vertebral fracture is dramatically reduced wit...

journal_title：Current osteoporosis reports

authors： Fixen C,Tunoa J

更新日期：2021-01-07 00:00:00

abstract：PURPOSE OF REVIEW:One aim in bone tissue engineering is to develop human cell-based, 3D in vitro bone models to study bone physiology and pathology. Due to the heterogeneity of cells among patients, patient's own cells are needed to be obtained, ideally, from one single cell source. This review attempts to identify the...

journal_title：Current osteoporosis reports

authors： Ansari S,Ito K,Hofmann S

更新日期：2021-01-15 00:00:00

abstract：:In a previous version of this publication, the author Mercedes Rodriguez Celin's name was listed as M.R. Celin. ...

journal_title：Current osteoporosis reports

authors： Rodriguez Celin M,Simon JC,Krzak JJ,Fial AV,Kruger KM,Smith PA,Harris GF

更新日期：2020-10-29 00:00:00

abstract：PURPOSE OF REVIEW:The goal of the review is to summarize the current knowledge on the process of chondrocyte-to-osteoblast transdifferentiation during endochondral bone formation and its potential implications in fracture healing and disease. RECENT FINDINGS:Lineage tracing experiments confirmed the transdifferentiati...

journal_title：Current osteoporosis reports

authors： Wolff LI,Hartmann C

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to explore the role of monocyte chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone remodelling, particularly the action of osteoblasts and osteoclasts, and its role in the development and metastasis of cancers that target the bone. RECENT FINDI...

journal_title：Current osteoporosis reports

authors： Mulholland BS,Forwood MR,Morrison NA

更新日期：2019-12-01 00:00:00

abstract：:Caloric restriction caused by undernutrition or over-exercise is increasingly common and has significant health consequences such as hypothalamic amenorrhea, infertility, attainment of low peak bone mass, and bone loss leading to fracture. In these patients, the pathophysiology of amenorrhea and bone loss is multifact...

journal_title：Current osteoporosis reports

authors： Fenichel RM,Warren MP

更新日期：2007-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review critiques the ability of CT-based methods to predict incident hip and vertebral fractures. RECENT FINDINGS:CT-based techniques with concurrent calibration all show strong associations with incident hip and vertebral fracture, predicting hip and vertebral fractures as well as, and sometime...

journal_title：Current osteoporosis reports

authors： Johannesdottir F,Allaire B,Bouxsein ML

更新日期：2018-08-01 00:00:00

abstract：:Osteoporosis in men is an unrecognized but growing problem as the number of men who live to old age increases. The 10-year fracture risk at age 50 quadruples by age 80, and in general the incidence rate of osteoporotic fracture in men is about half that of women. Of note, the mortality and morbidity after hip fracture...

journal_title：Current osteoporosis reports

authors： Adler RA

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF THIS REVIEW:The goal of the review is to provide an updated understanding of the pathophysiology of glucocorticoid-induced osteoporosis and treatment recommendations. RECENT FINDINGS:Glucocorticoids reduce osteoblast and osteocyte lifespan and activity and reduce the vascularity of the bone that together ma...

journal_title：Current osteoporosis reports

authors： Lane NE

更新日期：2019-02-01 00:00:00

abstract：:Vitamin D, acting through its active metabolite 1,25(OH)(2)D(3), exerts its influence on many physiologic processes in addition to the regulation of calcium and phosphate homeostasis. These processes include the immune system. Both the adaptive and innate immune systems are affected by 1,25(OH)(2)D(3) and its receptor...

journal_title：Current osteoporosis reports

authors： Bikle DD

更新日期：2009-07-01 00:00:00

abstract：:The pediatric origin of osteoporosis has led many investigators to focus on determining factors that influence bone gain during growth and methods for optimizing this gain. Bone responds to bone loading activities by increasing mass or size. Overall, pediatric studies have found a positive effect of bone loading on bo...

journal_title：Current osteoporosis reports

authors： Specker B,Minett M

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteocytes comprise > 95% of the cellular component in bone tissue and produce a wide range of cytokines and cellular signaling molecules in response to mechanical stimuli. In this review, we aimed to summarize the molecular mechanisms involved in the osteocyte-mediated translation of mechanical stimu...

journal_title：Current osteoporosis reports

authors： Yan Y,Wang L,Ge L,Pathak JL

更新日期：2020-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Mechanical loading is an essential stimulus for skeletal tissues. Osteocytes are primarily responsible for sensing mechanical stimuli in bone and for orchestrating subsequent responses. This is critical for maintaining homeostasis, and responding to injury/disease. The osteocyte mechanotransduction pa...

journal_title：Current osteoporosis reports

authors： Hinton PV,Rackard SM,Kennedy OD

更新日期：2018-12-01 00:00:00

abstract：:Although substantial increases in survival rates among children diagnosed with cancer have been observed in recent decades, survivors are at risk of developing therapy-related chronic health conditions. Among children and adolescents treated for cancer, acquisition of peak bone mass may be compromised by cancer therap...

journal_title：Current osteoporosis reports

authors： Wilson CL,Ness KK

更新日期：2013-12-01 00:00:00

abstract：:Osteoporotic fractures result in significant morbidity and mortality. Anabolic agents reverse the negative skeletal balance that characterizes osteoporosis by stimulating osteoblast-dependent bone formation to a greater degree than osteoclast-dependent bone resorption. Parathyroid hormone (PTH) and parathyroid hormone...

journal_title：Current osteoporosis reports

authors： Augustine M,Horwitz MJ

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Diabetes has a detrimental effect on bone, increasing the risk of fracture and formation of osteolytic lesions such as those seen in periodontitis. Several diabetic complications are caused by diabetes-enhanced inflammation. This review examines mechanisms by which IL-17 contributes to diabetes-enhanc...

journal_title：Current osteoporosis reports

authors： Huang Z,Pei X,Graves DT

更新日期：2020-02-01 00:00:00

abstract：:Although traditional diagnosis and treatment of renal osteodystrophy focused on changes in bone turnover, current data demonstrate that abnormalities in skeletal mineralization are also prevalent in pediatric chronic kidney disease (CKD) and likely contribute to skeletal morbidities that continue to plague this popula...

journal_title：Current osteoporosis reports

authors： Wesseling-Perry K

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteogenesis is a complex process involving the specification of multiple progenitor cells and their maturation and differentiation into matrix-secreting osteoblasts. Osteogenesis occurs not only during embryogenesis but also during growth, after an injury, and in normal homeostatic maintenance. While...

journal_title：Current osteoporosis reports

authors： Sera SR,Zur Nieden NI

更新日期：2017-08-01 00:00:00

abstract：:Surrogate markers in clinical medicine provide a useful means to assess therapeutic response to pharmacologic therapy in a wide range of chronic disease states. In the area of osteoporosis, the surrogate markers of change in bone mineral density (BMD) and bone turnover markers (BTM) provide the clinician with a means ...

journal_title：Current osteoporosis reports

authors： Miller PD

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review was to compile a list of tools currently available to study bone cells and in particular osteocytes. As the interest (and importance) in osteocyte biology has greatly expanded over the past decade, new tools and techniques have become available to study these elusive cells, RECE...

journal_title：Current osteoporosis reports

authors： Divieti Pajevic P

更新日期：2020-10-01 00:00:00

abstract：:Osteoporosis presents a dilemma for the orthopedic surgeon. Screw fixation within the bone is crucial for mechanical stabilization, maintenance of reduction, and ultimately, fracture healing. For the patient, soft bones and physiological fragility usually benefit from immediate weight bearing and mobility to avoid fur...

journal_title：Current osteoporosis reports

authors： Jones CB

更新日期：2012-12-01 00:00:00

abstract：:As the population with HIV continues to age, specialists in HIV care are increasingly encountering chronic health conditions, which now include osteoporosis, osteopenia, and fragility fractures. The pathophysiology of the bone effects of HIV infection is complex and includes traditional risk factors for bone loss as w...

journal_title：Current osteoporosis reports

authors： Rothman MS,Bessesen MT

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This paper describes recent advances in understanding the mechanisms that drive fracture pain and how these findings are helping develop new therapies to treat fracture pain. RECENT FINDINGS:Immediately following fracture, mechanosensitive nerve fibers that innervate bone are mechanically distorted. ...

journal_title：Current osteoporosis reports

authors： Mitchell SAT,Majuta LA,Mantyh PW

更新日期：2018-08-01 00:00:00

abstract：:Osteocytes, the most abundant cell type in bone, remain the least characterized. Several theories have been proposed regarding their function, including osteolysis, sensing the strains produced in response to mechanical loading of bones, and producing signals that affect the function of osteoblasts and osteoclasts and...

journal_title：Current osteoporosis reports

authors： Kogianni G,Noble BS

更新日期：2007-06-01 00:00:00

abstract：:The postmenopausal state is the most common underlying cause for osteoporosis and most of our understanding of the condition relates to this group. Recent evidence has suggested that hormone therapy may no longer have the pre-eminent place it once held but the same studies have also confirmed its antifracture efficacy...

journal_title：Current osteoporosis reports

authors： Selby P

更新日期：2004-09-01 00:00:00

abstract：:Establishing a Fracture Liaison Service (FLS) to identify and treat patients with a recent fragility fracture has been shown to be effective, save money, useful to document high quality of care, and makes good clinical sense. A FLS starts with an osteoporosis champion and encompasses identification of patients with a ...

journal_title：Current osteoporosis reports

authors： Curtis JR,Silverman SL

更新日期：2013-12-01 00:00:00

abstract：:Statistical models (SMs) of shape (SSM) and appearance (SAM) have been acquiring popularity in medical image analysis since they were introduced in the early 1990s. They have been primarily used for segmentation, but they are also a powerful tool for 3D reconstruction and classification. All these tasks may be require...

journal_title：Current osteoporosis reports

authors： Castro-Mateos I,Pozo JM,Cootes TF,Wilkinson JM,Eastell R,Frangi AF

更新日期：2014-06-01 00:00:00

abstract：:Calcium is the dominant mineral in bone and is a shortfall nutrient in the diet. For those consuming inadequate dietary calcium, calcium supplements have been a standard strategy for prevention of osteoporosis. Recently, calcium supplementation has been linked to both increased and decreased cardiovascular disease ris...

journal_title：Current osteoporosis reports

authors： Weaver CM

更新日期：2014-06-01 00:00:00