New and Old Osteocytic Cell Lines and 3D Models.

Abstract:

PURPOSE OF REVIEW:The aim of this review was to compile a list of tools currently available to study bone cells and in particular osteocytes. As the interest (and importance) in osteocyte biology has greatly expanded over the past decade, new tools and techniques have become available to study these elusive cells, RECENT FINDINGS: Osteocytes are the main orchestrators of bone remodeling. They control both osteoblasts and osteoclast activities via cell-to cell communication or through secreted factors. Osteocytes are also the mechanosensors of the bone and they orchestrate skeletal adaptation to loads. Recent discoveries have greatly expanded our knowledge and understanding of these cells and new models are now available to further uncover the functions of osteocytes. Novel osteocytic cell lines, primary cultures, and 3D scaffolds are now available to investigators to further unravel the functions and roles of these cells.

journal_name

Curr Osteoporos Rep

authors

Divieti Pajevic P

doi

10.1007/s11914-020-00613-3

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

551-558

issue

5

eissn

1544-1873

issn

1544-2241

pii

10.1007/s11914-020-00613-3

journal_volume

18

pub_type

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