Abstract：
PURPOSE OF REVIEW:Mechanical loading is an essential stimulus for skeletal tissues. Osteocytes are primarily responsible for sensing mechanical stimuli in bone and for orchestrating subsequent responses. This is critical for maintaining homeostasis, and responding to injury/disease. The osteocyte mechanotransduction pathway, and the downstream effects it mediates, is highly complex. In vivo models have proved invaluable in understanding this process. This review summarizes the commonly used models, as well as more recently developed ones, and describes how they are used to address emerging questions in the field. RECENT FINDINGS:Minimally invasive animal models can be used to determine mechanisms of osteocyte mechanotransduction, at the cell and molecular level, while simultaneously reducing potentially confounding responses such as inflammation/wound-healing. The details of osteocyte mechanotransduction in bone are gradually becoming clearer. In vivo model systems are a key tool in pursing this question. Advances in this field are explored and discussed in this review.
journal_name
Curr Osteoporos Repjournal_title
Current osteoporosis reportsauthors
Hinton PV,Rackard SM,Kennedy ODdoi
10.1007/s11914-018-0485-1subject
Has Abstractpub_date
2018-12-01 00:00:00pages
746-753issue
6eissn
1544-1873issn
1544-2241pii
10.1007/s11914-018-0485-1journal_volume
16pub_type
杂志文章,评审abstract：:Musculoskeletal pain disorders are the second largest contributor to global disability underlining the significance of effective treatments. However, treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in particular, is challenging as the underlying peripheral and central pain mechanism...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-015-0276-x
更新日期：2015-08-01 00:00:00
abstract：PURPOSE OF REVIEW:The age-related loss of skeletal muscle and bone tissue decreases functionality and increases the risk for falls and injuries. One contributing factor of muscle and bone loss over time is chronic low-grade inflammation. Exercise training is an effective countermeasure for decreasing the loss of muscle...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00596-1
更新日期：2020-08-01 00:00:00
abstract：:Statistical models (SMs) of shape (SSM) and appearance (SAM) have been acquiring popularity in medical image analysis since they were introduced in the early 1990s. They have been primarily used for segmentation, but they are also a powerful tool for 3D reconstruction and classification. All these tasks may be require...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0206-3
更新日期：2014-06-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-012-0124-1
更新日期：2012-12-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-996-0002-9
更新日期：2003-12-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-016-0320-5
更新日期：2016-10-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-012-0116-1
更新日期：2012-12-01 00:00:00
abstract：:Musculoskeletal diseases are highly prevalent with staggering annual health care costs across the globe. The combined wasting of muscle (sarcopenia) and bone (osteoporosis)-both in normal aging and pathologic states-can lead to vastly compounded risk for fracture in patients. Until now, our therapeutic approach to the...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0204-5
更新日期：2014-06-01 00:00:00
abstract：PURPOSE OF REVIEW:This review outlines the recent findings regarding the impact of bariatric surgery on bone. It explores potential mechanisms for skeletal changes following bariatric surgery and strategies for management. RECENT FINDINGS:Bone loss following bariatric surgery is multifactorial. Probable mechanisms inc...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00579-2
更新日期：2020-06-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章
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更新日期：2009-07-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-013-0147-2
更新日期：2013-09-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0208-1
更新日期：2014-06-01 00:00:00
abstract：PURPOSE OF REVIEW:To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs). RECENT FINDINGS:The results show that the physical and chemical properties of the nanomaterials are suitable f...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-018-0476-2
更新日期：2018-10-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-003-0003-x
更新日期：2003-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Osteogenesis is a complex process involving the specification of multiple progenitor cells and their maturation and differentiation into matrix-secreting osteoblasts. Osteogenesis occurs not only during embryogenesis but also during growth, after an injury, and in normal homeostatic maintenance. While...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-017-0379-7
更新日期：2017-08-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00613-3
更新日期：2020-10-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-011-0075-y
更新日期：2011-12-01 00:00:00
abstract：:Osteoporosis is characterized by the occurrence of a host of fractures. According to densitometric values, an operational definition for osteoporosis corresponds to a loss of 25% to 30% (-2.5 T-scores) compared with the mean values of bone mineral density of young premenopausal women. For years, research tried to deve...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-010-0024-1
更新日期：2010-09-01 00:00:00
abstract：:Bone metastasis is a deadly complication of cancers arising from many different primary tumor locations. Cross talk between cancer and bone cells is a well-established driver of bone metastasis, and recent work reveals microRNA (miRNA) as key players in this communication. Functional significance of miRNA was first de...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-016-0316-1
更新日期：2016-10-01 00:00:00
abstract：PURPOSE OF THIS REVIEW:The goal of the review is to provide an updated understanding of the pathophysiology of glucocorticoid-induced osteoporosis and treatment recommendations. RECENT FINDINGS:Glucocorticoids reduce osteoblast and osteocyte lifespan and activity and reduce the vascularity of the bone that together ma...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00498-x
更新日期：2019-02-01 00:00:00
abstract：PURPOSE OF REVIEW:The aims of this review are to summarize current performance for osteoporosis quality measures used by Centers for Medicare and Medicaid (CMS) for pay-for-performance programs and to describe recent quality improvement strategies around these measures. RECENT FINDINGS:Healthcare Effectiveness Data an...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
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更新日期：2019-12-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-018-0450-z
更新日期：2018-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Osteocytes comprise > 95% of the cellular component in bone tissue and produce a wide range of cytokines and cellular signaling molecules in response to mechanical stimuli. In this review, we aimed to summarize the molecular mechanisms involved in the osteocyte-mediated translation of mechanical stimu...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00564-9
更新日期：2020-02-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 已发布勘误
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更新日期：2020-10-29 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-007-0011-3
更新日期：2007-12-01 00:00:00
abstract：:The postmenopausal state is the most common underlying cause for osteoporosis and most of our understanding of the condition relates to this group. Recent evidence has suggested that hormone therapy may no longer have the pre-eminent place it once held but the same studies have also confirmed its antifracture efficacy...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-004-0018-y
更新日期：2004-09-01 00:00:00
abstract：:Osteocytes, the most abundant cell type in bone, remain the least characterized. Several theories have been proposed regarding their function, including osteolysis, sensing the strains produced in response to mechanical loading of bones, and producing signals that affect the function of osteoblasts and osteoclasts and...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-007-0007-z
更新日期：2007-06-01 00:00:00
abstract：:Currently, the measurement of areal bone mineral density (aBMD) is used at NASA to evaluate the effects of spaceflight on the skeletal health of astronauts. Notably, there are precipitous declines in aBMD with losses >10 % detected in the hip and spine in some astronauts following a typical 6-month mission in space. H...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
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更新日期：2013-06-01 00:00:00
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journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
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更新日期：2019-12-01 00:00:00
abstract：PURPOSE OF REVIEW:We give an update on the etiology and potential treatment options of rare inherited monogenic disorders associated with arterial calcification and calcific cardiac valve disease. RECENT FINDINGS:Genetic studies of rare inherited syndromes have identified key regulators of ectopic calcification. Based...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-017-0370-3
更新日期：2017-08-01 00:00:00
