Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) Drives Activation of Bone Remodelling and Skeletal Metastasis.

abstract：PURPOSE OF REVIEW:We outline the diverse processes contributing to bone mineralization and bone matrix maturation by describing two mouse models with bone strength defects caused by restricted deletion of the receptor tyrosine kinase ligand EphrinB2. RECENT FINDINGS:Stage-specific EphrinB2 deletion differs in its effe...

journal_title：Current osteoporosis reports

authors： Blank M,Sims NA

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review outlines the recent findings regarding the impact of bariatric surgery on bone. It explores potential mechanisms for skeletal changes following bariatric surgery and strategies for management. RECENT FINDINGS:Bone loss following bariatric surgery is multifactorial. Probable mechanisms inc...

journal_title：Current osteoporosis reports

authors： Krez AN,Stein EM

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This study aims to describe bone marrow fat changes in diabetes and to discuss the potential role of marrow fat in skeletal fragility. RECENT FINDINGS:Advances in non-invasive imaging have facilitated marrow fat research in humans. In contrast to animal studies which clearly demonstrate higher levels...

journal_title：Current osteoporosis reports

authors： Kim TY,Schafer AL

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this paper is to review state-of-the-art transcriptome profiling methods and their recent applications in the field of skeletal biology. RECENT FINDINGS:Next-generation sequencing of mRNA (RNA-seq) methods have been established and routinely used in skeletal biology research. RNA-seq has ...

journal_title：Current osteoporosis reports

authors： Ayturk U

更新日期：2019-08-01 00:00:00

abstract：:Substantial evidence exists that in addition to the well-known complications of diabetes, increased fracture risk is an important morbidity. This risk is probably due, at least in part, to altered bone remodeling and bone cell function in diabetes. Circulating biochemical markers of bone formation, including P1NP, ost...

journal_title：Current osteoporosis reports

authors： Rubin MR

更新日期：2015-06-01 00:00:00

abstract：:Establishing a Fracture Liaison Service (FLS) to identify and treat patients with a recent fragility fracture has been shown to be effective, save money, useful to document high quality of care, and makes good clinical sense. A FLS starts with an osteoporosis champion and encompasses identification of patients with a ...

journal_title：Current osteoporosis reports

authors： Curtis JR,Silverman SL

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteogenesis is a complex process involving the specification of multiple progenitor cells and their maturation and differentiation into matrix-secreting osteoblasts. Osteogenesis occurs not only during embryogenesis but also during growth, after an injury, and in normal homeostatic maintenance. While...

journal_title：Current osteoporosis reports

authors： Sera SR,Zur Nieden NI

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review critiques the ability of CT-based methods to predict incident hip and vertebral fractures. RECENT FINDINGS:CT-based techniques with concurrent calibration all show strong associations with incident hip and vertebral fracture, predicting hip and vertebral fractures as well as, and sometime...

journal_title：Current osteoporosis reports

authors： Johannesdottir F,Allaire B,Bouxsein ML

更新日期：2018-08-01 00:00:00

abstract：:Osteoporosis presents a dilemma for the orthopedic surgeon. Screw fixation within the bone is crucial for mechanical stabilization, maintenance of reduction, and ultimately, fracture healing. For the patient, soft bones and physiological fragility usually benefit from immediate weight bearing and mobility to avoid fur...

journal_title：Current osteoporosis reports

authors： Jones CB

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteocytes comprise > 95% of the cellular component in bone tissue and produce a wide range of cytokines and cellular signaling molecules in response to mechanical stimuli. In this review, we aimed to summarize the molecular mechanisms involved in the osteocyte-mediated translation of mechanical stimu...

journal_title：Current osteoporosis reports

authors： Yan Y,Wang L,Ge L,Pathak JL

更新日期：2020-02-01 00:00:00

abstract：:Nutritional status is an essential component in determining whole body energy homeostasis. The balance between energy/food intake and metabolism is governed by a range of hormones secreted from various parts of the body. Their subsequent dissemination via the blood results in a wide range of biological responses inclu...

journal_title：Current osteoporosis reports

authors： Khor EC,Wee NK,Baldock PA

更新日期：2013-09-01 00:00:00

abstract：:Microcrack accumulation in cortical bone has been implicated in skeletal fragility and stress fractures. These cracks have also been shown to affect the mechanical and material properties of cortical bone. Their growth has been linked to osteocyte apoptosis and the initiation of the remodeling process, which also has ...

journal_title：Current osteoporosis reports

authors： O'Brien FJ,Brennan O,Kennedy OD,Lee TC

更新日期：2005-06-01 00:00:00

abstract：:Although substantial increases in survival rates among children diagnosed with cancer have been observed in recent decades, survivors are at risk of developing therapy-related chronic health conditions. Among children and adolescents treated for cancer, acquisition of peak bone mass may be compromised by cancer therap...

journal_title：Current osteoporosis reports

authors： Wilson CL,Ness KK

更新日期：2013-12-01 00:00:00

abstract：:Low vitamin D status, which is endemic due to inadequate oral intake combined with sun avoidance, contributes to musculoskeletal and other pathologies. Although controversial, it is increasingly recommended that serum 25-hydroxyvitamin D (25D) concentrations less than 30 ng/mL be considered suboptimal. Clinicians shou...

journal_title：Current osteoporosis reports

authors： Binkley N,Krueger D

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize reports published since the 2013 American Society of Bone and Mineral Research Task Force Report on atypical femoral fractures (AFF). RECENT FINDINGS:The absolute incidence of AFFs remains low. AFFs are primarily associated with prolonged bisphosphonate (BP) exposure, but have also been ...

journal_title：Current osteoporosis reports

authors： Starr J,Tay YKD,Shane E

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Neurogenic heterotopic ossification (NHO) is the abnormal formation of extra-skeletal bones in periarticular muscles after damage to the central nervous system (CNS) such as spinal cord injury (SCI), traumatic brain injury (TBI), stroke, or cerebral anoxia. The purpose of this review is to summarize r...

journal_title：Current osteoporosis reports

authors： Alexander KA,Tseng HW,Salga M,Genêt F,Levesque JP

更新日期：2020-12-01 00:00:00

abstract：:Atraumatic fractures of the skeleton in osteoporotic patients are directly related to a deterioration of bone strength. However, the failure of the bone tissue to withstand functional load bearing cannot be explained as a simple decrease in bone mineral density (quantity); strength is also significantly dependent upon...

journal_title：Current osteoporosis reports

authors： Judex S,Boyd S,Qin YX,Miller L,Müller R,Rubin C

更新日期：2003-06-01 00:00:00

abstract：:The musculoskeletal system is a complex organ comprised of the skeletal bones, skeletal muscles, tendons, ligaments, cartilage, joints, and other connective tissue that physically and mechanically interact to provide animals and humans with the essential ability of locomotion. This mechanical interaction is undoubtedl...

journal_title：Current osteoporosis reports

authors： Brotto M,Johnson ML

更新日期：2014-06-01 00:00:00

abstract：:Microbial biofilms have been observed and described in bone specimens of patients with bisphosphonate (BP)-associated osteonecrosis of the jaw (BONJ) and investigators are more recently suggesting that this condition essentially represents an osteomyelitis of the jaw clinically, with greater susceptibility in some pat...

journal_title：Current osteoporosis reports

authors： Kumar SK,Gorur A,Schaudinn C,Shuler CF,Costerton JW,Sedghizadeh PP

更新日期：2010-03-01 00:00:00

abstract：:The past decade has seen a significant expansion of our understanding of the interaction between the neural system and bone. While innervation of bone was long appreciated, the discovery of central relays from the hypothalamus to the cells of bone has seen the identification of a number of efferent neural pathways to ...

journal_title：Current osteoporosis reports

authors： Khor EC,Baldock P

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:One aim in bone tissue engineering is to develop human cell-based, 3D in vitro bone models to study bone physiology and pathology. Due to the heterogeneity of cells among patients, patient's own cells are needed to be obtained, ideally, from one single cell source. This review attempts to identify the...

journal_title：Current osteoporosis reports

authors： Ansari S,Ito K,Hofmann S

更新日期：2021-01-15 00:00:00

abstract：PURPOSE OF THIS REVIEW:The goal of the review is to provide an updated understanding of the pathophysiology of glucocorticoid-induced osteoporosis and treatment recommendations. RECENT FINDINGS:Glucocorticoids reduce osteoblast and osteocyte lifespan and activity and reduce the vascularity of the bone that together ma...

journal_title：Current osteoporosis reports

authors： Lane NE

更新日期：2019-02-01 00:00:00

abstract：:Stem cells differ from other cells of the body in their potential for multilineage differentiation and their continued proliferation without substantial loss of potential (so-called self-renewal). These properties are maintained and regulated by a specific microenvironment referred to as "niche." This term has been us...

journal_title：Current osteoporosis reports

authors： Isern J,Méndez-Ferrer S

更新日期：2011-12-01 00:00:00

abstract：:In a previous version of this publication, the author Mercedes Rodriguez Celin's name was listed as M.R. Celin. ...

journal_title：Current osteoporosis reports

authors： Rodriguez Celin M,Simon JC,Krzak JJ,Fial AV,Kruger KM,Smith PA,Harris GF

更新日期：2020-10-29 00:00:00

abstract：:Osteoporotic fractures result in significant morbidity and mortality. Anabolic agents reverse the negative skeletal balance that characterizes osteoporosis by stimulating osteoblast-dependent bone formation to a greater degree than osteoclast-dependent bone resorption. Parathyroid hormone (PTH) and parathyroid hormone...

journal_title：Current osteoporosis reports

authors： Augustine M,Horwitz MJ

更新日期：2013-12-01 00:00:00

abstract：:Statistical models (SMs) of shape (SSM) and appearance (SAM) have been acquiring popularity in medical image analysis since they were introduced in the early 1990s. They have been primarily used for segmentation, but they are also a powerful tool for 3D reconstruction and classification. All these tasks may be require...

journal_title：Current osteoporosis reports

authors： Castro-Mateos I,Pozo JM,Cootes TF,Wilkinson JM,Eastell R,Frangi AF

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:In addition to the actions of the endocrine hormone, 1alpha,25-dihydroxyvitamin D (1,25(OH)2D) in stimulating intestinal calcium absorption, the regulation of bone mineral metabolism by 1,25(OH)2D is also considered an important contributor to calcium homeostasis. However, recent evidence suggest that...

journal_title：Current osteoporosis reports

authors： Anderson PH

更新日期：2017-10-01 00:00:00

abstract：:Although traditional diagnosis and treatment of renal osteodystrophy focused on changes in bone turnover, current data demonstrate that abnormalities in skeletal mineralization are also prevalent in pediatric chronic kidney disease (CKD) and likely contribute to skeletal morbidities that continue to plague this popula...

journal_title：Current osteoporosis reports

authors： Wesseling-Perry K

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The aims of this review are to summarize current performance for osteoporosis quality measures used by Centers for Medicare and Medicaid (CMS) for pay-for-performance programs and to describe recent quality improvement strategies around these measures. RECENT FINDINGS:Healthcare Effectiveness Data an...

journal_title：Current osteoporosis reports

authors： French S,Choden S,Schmajuk G

更新日期：2019-12-01 00:00:00

abstract：:Although vitamin D is used mainly as a nutritional supplement in osteoporosis treatment, its active form, 1,25-dihydroxyvitamin D [1,25(OH)(2)D], has an effect to maintain bone remodeling balance as well. Eldecalcitol is an analog of 1,25(OH) (2)D(3) with stronger effects than its native form in improving bone remodel...

journal_title：Current osteoporosis reports

authors： Matsumoto T

更新日期：2012-12-01 00:00:00