Augmentation of implant fixation in osteoporotic bone.

Abstract:

:Osteoporosis presents a dilemma for the orthopedic surgeon. Screw fixation within the bone is crucial for mechanical stabilization, maintenance of reduction, and ultimately, fracture healing. For the patient, soft bones and physiological fragility usually benefit from immediate weight bearing and mobility to avoid further disuse osteoporosis, deconditioning, and immobility. For implant companies, traditional screws, plates, and nails function for simple fractures and compliant patients. Locked plating has improved screw purchase in osteoporotic bone and has expanded fracture fixation capabilities but is not the panacea for all fractures. For orthopedic surgeons, traditional surgical augmentation for osteoporosis consisting of dual plating, augmentation with polymethyl methacrylate, joint replacement, and now locked plating are beneficial. In order to advance orthopedic care in the expanding population of elderly osteoporotic patients, modern solutions utilizing the dual properties of secure fixation and relatively flexible implants are required. Endosteal substitution, extraosteal substitution, and combined nail/plate combinations are methods of utilizing traditional implants in a nontraditional way. Nonsurgical augmentation of fracture fixation is also paramount.

journal_name

Curr Osteoporos Rep

authors

Jones CB

doi

10.1007/s11914-012-0124-1

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

328-36

issue

4

eissn

1544-1873

issn

1544-2241

journal_volume

10

pub_type

杂志文章
  • Parathyroid hormone and parathyroid hormone-related protein analogs as therapies for osteoporosis.

    abstract::Osteoporotic fractures result in significant morbidity and mortality. Anabolic agents reverse the negative skeletal balance that characterizes osteoporosis by stimulating osteoblast-dependent bone formation to a greater degree than osteoclast-dependent bone resorption. Parathyroid hormone (PTH) and parathyroid hormone...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-013-0171-2

    authors: Augustine M,Horwitz MJ

    更新日期:2013-12-01 00:00:00

  • Postmenopausal osteoporosis.

    abstract::The postmenopausal state is the most common underlying cause for osteoporosis and most of our understanding of the condition relates to this group. Recent evidence has suggested that hormone therapy may no longer have the pre-eminent place it once held but the same studies have also confirmed its antifracture efficacy...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-004-0018-y

    authors: Selby P

    更新日期:2004-09-01 00:00:00

  • Risk Factors, Epidemiology and Treatment Strategies for Metabolic Bone Disease in Patients with Neurological Disease.

    abstract::Metabolic bone disease is a major public health concern, especially when it manifests as hip fracture which carries significant morbidity and mortality. Individuals with neurological disease are at higher risk of osteopenia, osteoporosis and fragility fracture compared to age-matched controls, yet this is under-apprec...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-016-0320-5

    authors: Binks S,Dobson R

    更新日期:2016-10-01 00:00:00

  • Choosing a treatment for patients at the time a fracture is presented.

    abstract::The occurrence of a fragility fracture is an opportunity to recognize osteoporosis and begin treatment to reduce the risk of another fracture. However, selecting the treatment may have an impact on the incident fracture and this requires careful consideration of the patient and the treatment choices. There is no conse...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-011-0061-4

    authors: Tanner SB

    更新日期:2011-09-01 00:00:00

  • Mouse Models of Frailty: an Emerging Field.

    abstract::Frailty is highly prevalent in the elderly, increasing the risk of poor outcomes that include falls, incident disability, hospitalization, and mortality. Thus, a great need exists to characterize the underlying mechanisms and ultimately identify strategies that prevent, delay, and even reverse frailty. Mouse models ca...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-015-0283-y

    authors: Seldeen KL,Pang M,Troen BR

    更新日期:2015-10-01 00:00:00

  • Cell Sources for Human In vitro Bone Models.

    abstract:PURPOSE OF REVIEW:One aim in bone tissue engineering is to develop human cell-based, 3D in vitro bone models to study bone physiology and pathology. Due to the heterogeneity of cells among patients, patient's own cells are needed to be obtained, ideally, from one single cell source. This review attempts to identify the...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-020-00648-6

    authors: Ansari S,Ito K,Hofmann S

    更新日期:2021-01-15 00:00:00

  • Combining high-resolution micro-computed tomography with material composition to define the quality of bone tissue.

    abstract::Atraumatic fractures of the skeleton in osteoporotic patients are directly related to a deterioration of bone strength. However, the failure of the bone tissue to withstand functional load bearing cannot be explained as a simple decrease in bone mineral density (quantity); strength is also significantly dependent upon...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-003-0003-x

    authors: Judex S,Boyd S,Qin YX,Miller L,Müller R,Rubin C

    更新日期:2003-06-01 00:00:00

  • The Interrelationship Between Diabetes, IL-17 and Bone Loss.

    abstract:PURPOSE OF REVIEW:Diabetes has a detrimental effect on bone, increasing the risk of fracture and formation of osteolytic lesions such as those seen in periodontitis. Several diabetic complications are caused by diabetes-enhanced inflammation. This review examines mechanisms by which IL-17 contributes to diabetes-enhanc...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-020-00559-6

    authors: Huang Z,Pei X,Graves DT

    更新日期:2020-02-01 00:00:00

  • Endocrine crosstalk between muscle and bone.

    abstract::The musculoskeletal system is a complex organ comprised of the skeletal bones, skeletal muscles, tendons, ligaments, cartilage, joints, and other connective tissue that physically and mechanically interact to provide animals and humans with the essential ability of locomotion. This mechanical interaction is undoubtedl...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-014-0209-0

    authors: Brotto M,Johnson ML

    更新日期:2014-06-01 00:00:00

  • Stem cell interactions in a bone marrow niche.

    abstract::Stem cells differ from other cells of the body in their potential for multilineage differentiation and their continued proliferation without substantial loss of potential (so-called self-renewal). These properties are maintained and regulated by a specific microenvironment referred to as "niche." This term has been us...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-011-0075-y

    authors: Isern J,Méndez-Ferrer S

    更新日期:2011-12-01 00:00:00

  • The Cannabinoids Effect on Bone Formation and Bone Healing.

    abstract:PURPOSE OF REVIEW:Here, we overview the latest findings from studies investigating the skeletal endocannabinoid (EC) system and its involvement in bone formation and resorption. RECENT FINDINGS:The endocannabinoid system consists of endogenous ligands, receptors, and enzymes. The main cannabinoids found in the cannabi...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-020-00607-1

    authors: Raphael-Mizrahi B,Gabet Y

    更新日期:2020-10-01 00:00:00

  • Microcracks in cortical bone: how do they affect bone biology?

    abstract::Microcrack accumulation in cortical bone has been implicated in skeletal fragility and stress fractures. These cracks have also been shown to affect the mechanical and material properties of cortical bone. Their growth has been linked to osteocyte apoptosis and the initiation of the remodeling process, which also has ...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-005-0002-1

    authors: O'Brien FJ,Brennan O,Kennedy OD,Lee TC

    更新日期:2005-06-01 00:00:00

  • Anorexia, bulimia, and the athletic triad: evaluation and management.

    abstract::Caloric restriction caused by undernutrition or over-exercise is increasingly common and has significant health consequences such as hypothalamic amenorrhea, infertility, attainment of low peak bone mass, and bone loss leading to fracture. In these patients, the pathophysiology of amenorrhea and bone loss is multifact...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-007-0011-3

    authors: Fenichel RM,Warren MP

    更新日期:2007-12-01 00:00:00

  • Vitamin D and immune function: understanding common pathways.

    abstract::Vitamin D, acting through its active metabolite 1,25(OH)(2)D(3), exerts its influence on many physiologic processes in addition to the regulation of calcium and phosphate homeostasis. These processes include the immune system. Both the adaptive and innate immune systems are affected by 1,25(OH)(2)D(3) and its receptor...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章

    doi:10.1007/s11914-009-0011-6

    authors: Bikle DD

    更新日期:2009-07-01 00:00:00

  • Inherited Arterial Calcification Syndromes: Etiologies and Treatment Concepts.

    abstract:PURPOSE OF REVIEW:We give an update on the etiology and potential treatment options of rare inherited monogenic disorders associated with arterial calcification and calcific cardiac valve disease. RECENT FINDINGS:Genetic studies of rare inherited syndromes have identified key regulators of ectopic calcification. Based...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-017-0370-3

    authors: Nitschke Y,Rutsch F

    更新日期:2017-08-01 00:00:00

  • Biomechanics of Osteoporotic Fracture Fixation.

    abstract:PURPOSE OF REVIEW:Fractures of osteoporotic bone in elderly individuals need special attention. This manuscript reviews the current strategies to provide sufficient fracture fixation stability with a particular focus on fractures that frequently occur in elderly individuals with osteoporosis and require full load-beari...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-019-00535-9

    authors: Hollensteiner M,Sandriesser S,Bliven E,von Rüden C,Augat P

    更新日期:2019-12-01 00:00:00

  • New Insights in Understanding and Treating Bone Fracture Pain.

    abstract:PURPOSE OF REVIEW:This paper describes recent advances in understanding the mechanisms that drive fracture pain and how these findings are helping develop new therapies to treat fracture pain. RECENT FINDINGS:Immediately following fracture, mechanosensitive nerve fibers that innervate bone are mechanically distorted. ...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-018-0446-8

    authors: Mitchell SAT,Majuta LA,Mantyh PW

    更新日期:2018-08-01 00:00:00

  • Bone mineral density deficits and fractures in survivors of childhood cancer.

    abstract::Although substantial increases in survival rates among children diagnosed with cancer have been observed in recent decades, survivors are at risk of developing therapy-related chronic health conditions. Among children and adolescents treated for cancer, acquisition of peak bone mass may be compromised by cancer therap...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-013-0165-0

    authors: Wilson CL,Ness KK

    更新日期:2013-12-01 00:00:00

  • The effects of smoke carcinogens on bone.

    abstract::The greatest cause of preventable morbidity and mortality is smoking, and one of the often-underappreciated effects of smoking is profound bone loss. The existing clinical paradigm for smoking is that there is a low turnover osteoporosis. This review highlights findings from recent clinical trials and animal research ...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-011-0068-x

    authors: Yan C,Avadhani NG,Iqbal J

    更新日期:2011-12-01 00:00:00

  • Commentary: the five Ws of a Fracture Liaison Service: why, who, what, where, and how? In osteoporosis, we reap what we sow.

    abstract::Establishing a Fracture Liaison Service (FLS) to identify and treat patients with a recent fragility fracture has been shown to be effective, save money, useful to document high quality of care, and makes good clinical sense. A FLS starts with an osteoporosis champion and encompasses identification of patients with a ...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章

    doi:10.1007/s11914-013-0177-9

    authors: Curtis JR,Silverman SL

    更新日期:2013-12-01 00:00:00

  • Vitamin D Activity and Metabolism in Bone.

    abstract:PURPOSE OF REVIEW:In addition to the actions of the endocrine hormone, 1alpha,25-dihydroxyvitamin D (1,25(OH)2D) in stimulating intestinal calcium absorption, the regulation of bone mineral metabolism by 1,25(OH)2D is also considered an important contributor to calcium homeostasis. However, recent evidence suggest that...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-017-0394-8

    authors: Anderson PH

    更新日期:2017-10-01 00:00:00

  • Biologicals in osteoporosis: teriparatide and parathyroid hormone in women and men.

    abstract::Osteoporosis is characterized by the occurrence of a host of fractures. According to densitometric values, an operational definition for osteoporosis corresponds to a loss of 25% to 30% (-2.5 T-scores) compared with the mean values of bone mineral density of young premenopausal women. For years, research tried to deve...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章

    doi:10.1007/s11914-010-0024-1

    authors: Devogelaer JP,Boutsen Y,Manicourt DH

    更新日期:2010-09-01 00:00:00

  • When the Nervous System Turns Skeletal Muscles into Bones: How to Solve the Conundrum of Neurogenic Heterotopic Ossification.

    abstract:PURPOSE OF REVIEW:Neurogenic heterotopic ossification (NHO) is the abnormal formation of extra-skeletal bones in periarticular muscles after damage to the central nervous system (CNS) such as spinal cord injury (SCI), traumatic brain injury (TBI), stroke, or cerebral anoxia. The purpose of this review is to summarize r...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-020-00636-w

    authors: Alexander KA,Tseng HW,Salga M,Genêt F,Levesque JP

    更新日期:2020-12-01 00:00:00

  • The biology of osteocytes.

    abstract::Osteocytes, the most abundant cell type in bone, remain the least characterized. Several theories have been proposed regarding their function, including osteolysis, sensing the strains produced in response to mechanical loading of bones, and producing signals that affect the function of osteoblasts and osteoclasts and...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-007-0007-z

    authors: Kogianni G,Noble BS

    更新日期:2007-06-01 00:00:00

  • Calcium supplementation: is protecting against osteoporosis counter to protecting against cardiovascular disease?

    abstract::Calcium is the dominant mineral in bone and is a shortfall nutrient in the diet. For those consuming inadequate dietary calcium, calcium supplements have been a standard strategy for prevention of osteoporosis. Recently, calcium supplementation has been linked to both increased and decreased cardiovascular disease ris...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-014-0208-1

    authors: Weaver CM

    更新日期:2014-06-01 00:00:00

  • Therapies for musculoskeletal disease: can we treat two birds with one stone?

    abstract::Musculoskeletal diseases are highly prevalent with staggering annual health care costs across the globe. The combined wasting of muscle (sarcopenia) and bone (osteoporosis)-both in normal aging and pathologic states-can lead to vastly compounded risk for fracture in patients. Until now, our therapeutic approach to the...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-014-0204-5

    authors: Girgis CM,Mokbel N,Digirolamo DJ

    更新日期:2014-06-01 00:00:00

  • Fracture Prediction by Computed Tomography and Finite Element Analysis: Current and Future Perspectives.

    abstract:PURPOSE OF REVIEW:This review critiques the ability of CT-based methods to predict incident hip and vertebral fractures. RECENT FINDINGS:CT-based techniques with concurrent calibration all show strong associations with incident hip and vertebral fracture, predicting hip and vertebral fractures as well as, and sometime...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-018-0450-z

    authors: Johannesdottir F,Allaire B,Bouxsein ML

    更新日期:2018-08-01 00:00:00

  • Epidemiology and pathophysiology of osteoporosis in men.

    abstract::Osteoporosis in men is an unrecognized but growing problem as the number of men who live to old age increases. The 10-year fracture risk at age 50 quadruples by age 80, and in general the incidence rate of osteoporotic fracture in men is about half that of women. Of note, the mortality and morbidity after hip fracture...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-996-0030-5

    authors: Adler RA

    更新日期:2006-09-01 00:00:00

  • HIV infection and osteoporosis: pathophysiology, diagnosis, and treatment options.

    abstract::As the population with HIV continues to age, specialists in HIV care are increasingly encountering chronic health conditions, which now include osteoporosis, osteopenia, and fragility fractures. The pathophysiology of the bone effects of HIV infection is complex and includes traditional risk factors for bone loss as w...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-012-0125-0

    authors: Rothman MS,Bessesen MT

    更新日期:2012-12-01 00:00:00

  • Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) Drives Activation of Bone Remodelling and Skeletal Metastasis.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to explore the role of monocyte chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone remodelling, particularly the action of osteoblasts and osteoclasts, and its role in the development and metastasis of cancers that target the bone. RECENT FINDI...

    journal_title:Current osteoporosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11914-019-00545-7

    authors: Mulholland BS,Forwood MR,Morrison NA

    更新日期:2019-12-01 00:00:00