Risk Factors, Epidemiology and Treatment Strategies for Metabolic Bone Disease in Patients with Neurological Disease.

Abstract:

:Metabolic bone disease is a major public health concern, especially when it manifests as hip fracture which carries significant morbidity and mortality. Individuals with neurological disease are at higher risk of osteopenia, osteoporosis and fragility fracture compared to age-matched controls, yet this is under-appreciated by these patients. Clinician attention to this topic is therefore of importance and should address the bone health of men as well as women, a group in whom it may be an under-recognised problem. Evidence for optimal management of bone health in neurological disease remains to be defined, but a growing literature provides some useful guidance. This review focuses on two conditions, multiple sclerosis and Parkinson's disease, where research has been active over recent years. In neuroinflammation, shared immunological pathways between bone and brain are a current domain of interest and it will be intriguing to interrogate the action of emerging immunotherapies on these dual compartments.

journal_name

Curr Osteoporos Rep

authors

Binks S,Dobson R

doi

10.1007/s11914-016-0320-5

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

199-210

issue

5

eissn

1544-1873

issn

1544-2241

pii

10.1007/s11914-016-0320-5

journal_volume

14

pub_type

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