Vitamin D Activity and Metabolism in Bone.

abstract：:Although traditional diagnosis and treatment of renal osteodystrophy focused on changes in bone turnover, current data demonstrate that abnormalities in skeletal mineralization are also prevalent in pediatric chronic kidney disease (CKD) and likely contribute to skeletal morbidities that continue to plague this popula...

journal_title：Current osteoporosis reports

authors： Wesseling-Perry K

更新日期：2015-04-01 00:00:00

abstract：:Although vitamin D is used mainly as a nutritional supplement in osteoporosis treatment, its active form, 1,25-dihydroxyvitamin D [1,25(OH)(2)D], has an effect to maintain bone remodeling balance as well. Eldecalcitol is an analog of 1,25(OH) (2)D(3) with stronger effects than its native form in improving bone remodel...

journal_title：Current osteoporosis reports

authors： Matsumoto T

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF THIS REVIEW:The goal of the review is to provide an updated understanding of the pathophysiology of glucocorticoid-induced osteoporosis and treatment recommendations. RECENT FINDINGS:Glucocorticoids reduce osteoblast and osteocyte lifespan and activity and reduce the vascularity of the bone that together ma...

journal_title：Current osteoporosis reports

authors： Lane NE

更新日期：2019-02-01 00:00:00

abstract：:Calcium is the dominant mineral in bone and is a shortfall nutrient in the diet. For those consuming inadequate dietary calcium, calcium supplements have been a standard strategy for prevention of osteoporosis. Recently, calcium supplementation has been linked to both increased and decreased cardiovascular disease ris...

journal_title：Current osteoporosis reports

authors： Weaver CM

更新日期：2014-06-01 00:00:00

abstract：:Metabolic bone disease is a major public health concern, especially when it manifests as hip fracture which carries significant morbidity and mortality. Individuals with neurological disease are at higher risk of osteopenia, osteoporosis and fragility fracture compared to age-matched controls, yet this is under-apprec...

journal_title：Current osteoporosis reports

authors： Binks S,Dobson R

更新日期：2016-10-01 00:00:00

abstract：:Microcrack accumulation in cortical bone has been implicated in skeletal fragility and stress fractures. These cracks have also been shown to affect the mechanical and material properties of cortical bone. Their growth has been linked to osteocyte apoptosis and the initiation of the remodeling process, which also has ...

journal_title：Current osteoporosis reports

authors： O'Brien FJ,Brennan O,Kennedy OD,Lee TC

更新日期：2005-06-01 00:00:00

abstract：:The greatest cause of preventable morbidity and mortality is smoking, and one of the often-underappreciated effects of smoking is profound bone loss. The existing clinical paradigm for smoking is that there is a low turnover osteoporosis. This review highlights findings from recent clinical trials and animal research ...

journal_title：Current osteoporosis reports

authors： Yan C,Avadhani NG,Iqbal J

更新日期：2011-12-01 00:00:00

abstract：:Osteocytes, the most abundant cell type in bone, remain the least characterized. Several theories have been proposed regarding their function, including osteolysis, sensing the strains produced in response to mechanical loading of bones, and producing signals that affect the function of osteoblasts and osteoclasts and...

journal_title：Current osteoporosis reports

authors： Kogianni G,Noble BS

更新日期：2007-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this paper is to review state-of-the-art transcriptome profiling methods and their recent applications in the field of skeletal biology. RECENT FINDINGS:Next-generation sequencing of mRNA (RNA-seq) methods have been established and routinely used in skeletal biology research. RNA-seq has ...

journal_title：Current osteoporosis reports

authors： Ayturk U

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Identifying individuals at high fracture risk can be used to target those likely to derive the greatest benefit from treatment. This narrative review examines recent developments in using specific risk factors used to assess fracture risk, with a focus on publications in the last 3 years. RECENT FIND...

journal_title：Current osteoporosis reports

authors： Leslie WD,Morin SN

更新日期：2020-06-01 00:00:00

abstract：:Stem cells differ from other cells of the body in their potential for multilineage differentiation and their continued proliferation without substantial loss of potential (so-called self-renewal). These properties are maintained and regulated by a specific microenvironment referred to as "niche." This term has been us...

journal_title：Current osteoporosis reports

authors： Isern J,Méndez-Ferrer S

更新日期：2011-12-01 00:00:00

abstract：:Low vitamin D status, which is endemic due to inadequate oral intake combined with sun avoidance, contributes to musculoskeletal and other pathologies. Although controversial, it is increasingly recommended that serum 25-hydroxyvitamin D (25D) concentrations less than 30 ng/mL be considered suboptimal. Clinicians shou...

journal_title：Current osteoporosis reports

authors： Binkley N,Krueger D

更新日期：2008-09-01 00:00:00

abstract：:Because there are now effective agents for treatment of osteoporosis, the question is being raised as to whether or not it is ethical to have placebo-controlled trials of new agents. It is ethical for patients who are at low risk of serious or irreversible harm to participate in placebo-controlled trials as long as th...

journal_title：Current osteoporosis reports

authors： Watts NB

更新日期：2004-03-01 00:00:00

abstract：:Frailty is highly prevalent in the elderly, increasing the risk of poor outcomes that include falls, incident disability, hospitalization, and mortality. Thus, a great need exists to characterize the underlying mechanisms and ultimately identify strategies that prevent, delay, and even reverse frailty. Mouse models ca...

journal_title：Current osteoporosis reports

authors： Seldeen KL,Pang M,Troen BR

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs). RECENT FINDINGS:The results show that the physical and chemical properties of the nanomaterials are suitable f...

journal_title：Current osteoporosis reports

authors： de Carvalho JO,de Carvalho Oliveira F,Freitas SAP,Soares LM,de Cássia Barros Lima R,de Sousa Gonçalves L,Webster TJ,Marciano FR,Lobo AO

更新日期：2018-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review critiques the ability of CT-based methods to predict incident hip and vertebral fractures. RECENT FINDINGS:CT-based techniques with concurrent calibration all show strong associations with incident hip and vertebral fracture, predicting hip and vertebral fractures as well as, and sometime...

journal_title：Current osteoporosis reports

authors： Johannesdottir F,Allaire B,Bouxsein ML

更新日期：2018-08-01 00:00:00

abstract：:Osteoporosis presents a dilemma for the orthopedic surgeon. Screw fixation within the bone is crucial for mechanical stabilization, maintenance of reduction, and ultimately, fracture healing. For the patient, soft bones and physiological fragility usually benefit from immediate weight bearing and mobility to avoid fur...

journal_title：Current osteoporosis reports

authors： Jones CB

更新日期：2012-12-01 00:00:00

abstract：:Surrogate markers in clinical medicine provide a useful means to assess therapeutic response to pharmacologic therapy in a wide range of chronic disease states. In the area of osteoporosis, the surrogate markers of change in bone mineral density (BMD) and bone turnover markers (BTM) provide the clinician with a means ...

journal_title：Current osteoporosis reports

authors： Miller PD

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of the review is to summarize the current knowledge on the process of chondrocyte-to-osteoblast transdifferentiation during endochondral bone formation and its potential implications in fracture healing and disease. RECENT FINDINGS:Lineage tracing experiments confirmed the transdifferentiati...

journal_title：Current osteoporosis reports

authors： Wolff LI,Hartmann C

更新日期：2019-06-01 00:00:00

abstract：:The musculoskeletal system is a complex organ comprised of the skeletal bones, skeletal muscles, tendons, ligaments, cartilage, joints, and other connective tissue that physically and mechanically interact to provide animals and humans with the essential ability of locomotion. This mechanical interaction is undoubtedl...

journal_title：Current osteoporosis reports

authors： Brotto M,Johnson ML

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Mechanical loading is an essential stimulus for skeletal tissues. Osteocytes are primarily responsible for sensing mechanical stimuli in bone and for orchestrating subsequent responses. This is critical for maintaining homeostasis, and responding to injury/disease. The osteocyte mechanotransduction pa...

journal_title：Current osteoporosis reports

authors： Hinton PV,Rackard SM,Kennedy OD

更新日期：2018-12-01 00:00:00

abstract：:Musculoskeletal pain disorders are the second largest contributor to global disability underlining the significance of effective treatments. However, treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in particular, is challenging as the underlying peripheral and central pain mechanism...

journal_title：Current osteoporosis reports

authors： Arendt-Nielsen L,Skou ST,Nielsen TA,Petersen KK

更新日期：2015-08-01 00:00:00

abstract：:The pediatric origin of osteoporosis has led many investigators to focus on determining factors that influence bone gain during growth and methods for optimizing this gain. Bone responds to bone loading activities by increasing mass or size. Overall, pediatric studies have found a positive effect of bone loading on bo...

journal_title：Current osteoporosis reports

authors： Specker B,Minett M

更新日期：2013-09-01 00:00:00

abstract：:Although substantial increases in survival rates among children diagnosed with cancer have been observed in recent decades, survivors are at risk of developing therapy-related chronic health conditions. Among children and adolescents treated for cancer, acquisition of peak bone mass may be compromised by cancer therap...

journal_title：Current osteoporosis reports

authors： Wilson CL,Ness KK

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Fractures of osteoporotic bone in elderly individuals need special attention. This manuscript reviews the current strategies to provide sufficient fracture fixation stability with a particular focus on fractures that frequently occur in elderly individuals with osteoporosis and require full load-beari...

journal_title：Current osteoporosis reports

authors： Hollensteiner M,Sandriesser S,Bliven E,von Rüden C,Augat P

更新日期：2019-12-01 00:00:00

abstract：:Vitamin D, acting through its active metabolite 1,25(OH)(2)D(3), exerts its influence on many physiologic processes in addition to the regulation of calcium and phosphate homeostasis. These processes include the immune system. Both the adaptive and innate immune systems are affected by 1,25(OH)(2)D(3) and its receptor...

journal_title：Current osteoporosis reports

authors： Bikle DD

更新日期：2009-07-01 00:00:00

abstract：:There is an increasing repertoire of laboratory tests available for assessing the bone remodeling process. Biochemical markers of bone remodeling can be measured in serum or urine, and have a number of potential roles in the management of fracture risk. Differences in remodeling between individuals might be related to...

journal_title：Current osteoporosis reports

authors： Blumsohn A

更新日期：2003-12-01 00:00:00

abstract：:Musculoskeletal diseases are highly prevalent with staggering annual health care costs across the globe. The combined wasting of muscle (sarcopenia) and bone (osteoporosis)-both in normal aging and pathologic states-can lead to vastly compounded risk for fracture in patients. Until now, our therapeutic approach to the...

journal_title：Current osteoporosis reports

authors： Girgis CM,Mokbel N,Digirolamo DJ

更新日期：2014-06-01 00:00:00

abstract：:Osteoporotic fractures result in significant morbidity and mortality. Anabolic agents reverse the negative skeletal balance that characterizes osteoporosis by stimulating osteoblast-dependent bone formation to a greater degree than osteoclast-dependent bone resorption. Parathyroid hormone (PTH) and parathyroid hormone...

journal_title：Current osteoporosis reports

authors： Augustine M,Horwitz MJ

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review was to compile a list of tools currently available to study bone cells and in particular osteocytes. As the interest (and importance) in osteocyte biology has greatly expanded over the past decade, new tools and techniques have become available to study these elusive cells, RECE...

journal_title：Current osteoporosis reports

authors： Divieti Pajevic P

更新日期：2020-10-01 00:00:00