Statistical shape and appearance models in osteoporosis.

abstract：PURPOSE OF REVIEW:Neurogenic heterotopic ossification (NHO) is the abnormal formation of extra-skeletal bones in periarticular muscles after damage to the central nervous system (CNS) such as spinal cord injury (SCI), traumatic brain injury (TBI), stroke, or cerebral anoxia. The purpose of this review is to summarize r...

journal_title：Current osteoporosis reports

authors： Alexander KA,Tseng HW,Salga M,Genêt F,Levesque JP

更新日期：2020-12-01 00:00:00

abstract：:Osteoporosis is characterized by the occurrence of a host of fractures. According to densitometric values, an operational definition for osteoporosis corresponds to a loss of 25% to 30% (-2.5 T-scores) compared with the mean values of bone mineral density of young premenopausal women. For years, research tried to deve...

journal_title：Current osteoporosis reports

authors： Devogelaer JP,Boutsen Y,Manicourt DH

更新日期：2010-09-01 00:00:00

abstract：:Although vitamin D is used mainly as a nutritional supplement in osteoporosis treatment, its active form, 1,25-dihydroxyvitamin D [1,25(OH)(2)D], has an effect to maintain bone remodeling balance as well. Eldecalcitol is an analog of 1,25(OH) (2)D(3) with stronger effects than its native form in improving bone remodel...

journal_title：Current osteoporosis reports

authors： Matsumoto T

更新日期：2012-12-01 00:00:00

abstract：:A prior fracture is a well-documented risk factor for a subsequent fracture and it doubles the risk of subsequent fractures. Few studies have investigated the time that elapses between the initial and subsequent fracture. These studies show that the subsequent fracture risk is not constant, but fluctuates over time. T...

journal_title：Current osteoporosis reports

authors： van Geel TA,Huntjens KM,van den Bergh JP,Dinant GJ,Geusens PP

更新日期：2010-09-01 00:00:00

abstract：:There is an increasing repertoire of laboratory tests available for assessing the bone remodeling process. Biochemical markers of bone remodeling can be measured in serum or urine, and have a number of potential roles in the management of fracture risk. Differences in remodeling between individuals might be related to...

journal_title：Current osteoporosis reports

authors： Blumsohn A

更新日期：2003-12-01 00:00:00

abstract：:Bone metastasis is a deadly complication of cancers arising from many different primary tumor locations. Cross talk between cancer and bone cells is a well-established driver of bone metastasis, and recent work reveals microRNA (miRNA) as key players in this communication. Functional significance of miRNA was first de...

journal_title：Current osteoporosis reports

authors： Baier SR,Wan Y

更新日期：2016-10-01 00:00:00

abstract：:Calcium is the dominant mineral in bone and is a shortfall nutrient in the diet. For those consuming inadequate dietary calcium, calcium supplements have been a standard strategy for prevention of osteoporosis. Recently, calcium supplementation has been linked to both increased and decreased cardiovascular disease ris...

journal_title：Current osteoporosis reports

authors： Weaver CM

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:We outline the diverse processes contributing to bone mineralization and bone matrix maturation by describing two mouse models with bone strength defects caused by restricted deletion of the receptor tyrosine kinase ligand EphrinB2. RECENT FINDINGS:Stage-specific EphrinB2 deletion differs in its effe...

journal_title：Current osteoporosis reports

authors： Blank M,Sims NA

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review was to compile a list of tools currently available to study bone cells and in particular osteocytes. As the interest (and importance) in osteocyte biology has greatly expanded over the past decade, new tools and techniques have become available to study these elusive cells, RECE...

journal_title：Current osteoporosis reports

authors： Divieti Pajevic P

更新日期：2020-10-01 00:00:00

abstract：:Intercellular communication within the bone microenvironment is critical for the maintenance of normal bone structure. Osteoblast-lineage cells at all stages of differentiation, from pluripotent precursors to matrix-embedded osteocytes, produce regulatory factors that modulate the differentiation and activity of both ...

journal_title：Current osteoporosis reports

authors： Sims NA,Walsh NC

更新日期：2012-06-01 00:00:00

abstract：:Osteoporosis in men is an unrecognized but growing problem as the number of men who live to old age increases. The 10-year fracture risk at age 50 quadruples by age 80, and in general the incidence rate of osteoporotic fracture in men is about half that of women. Of note, the mortality and morbidity after hip fracture...

journal_title：Current osteoporosis reports

authors： Adler RA

更新日期：2006-09-01 00:00:00

abstract：:The greatest cause of preventable morbidity and mortality is smoking, and one of the often-underappreciated effects of smoking is profound bone loss. The existing clinical paradigm for smoking is that there is a low turnover osteoporosis. This review highlights findings from recent clinical trials and animal research ...

journal_title：Current osteoporosis reports

authors： Yan C,Avadhani NG,Iqbal J

更新日期：2011-12-01 00:00:00

abstract：:The pediatric origin of osteoporosis has led many investigators to focus on determining factors that influence bone gain during growth and methods for optimizing this gain. Bone responds to bone loading activities by increasing mass or size. Overall, pediatric studies have found a positive effect of bone loading on bo...

journal_title：Current osteoporosis reports

authors： Specker B,Minett M

更新日期：2013-09-01 00:00:00

abstract：:Osteoporosis presents a dilemma for the orthopedic surgeon. Screw fixation within the bone is crucial for mechanical stabilization, maintenance of reduction, and ultimately, fracture healing. For the patient, soft bones and physiological fragility usually benefit from immediate weight bearing and mobility to avoid fur...

journal_title：Current osteoporosis reports

authors： Jones CB

更新日期：2012-12-01 00:00:00

abstract：:Musculoskeletal diseases are highly prevalent with staggering annual health care costs across the globe. The combined wasting of muscle (sarcopenia) and bone (osteoporosis)-both in normal aging and pathologic states-can lead to vastly compounded risk for fracture in patients. Until now, our therapeutic approach to the...

journal_title：Current osteoporosis reports

authors： Girgis CM,Mokbel N,Digirolamo DJ

更新日期：2014-06-01 00:00:00

abstract：:Establishing a Fracture Liaison Service (FLS) to identify and treat patients with a recent fragility fracture has been shown to be effective, save money, useful to document high quality of care, and makes good clinical sense. A FLS starts with an osteoporosis champion and encompasses identification of patients with a ...

journal_title：Current osteoporosis reports

authors： Curtis JR,Silverman SL

更新日期：2013-12-01 00:00:00

abstract：:Although traditional diagnosis and treatment of renal osteodystrophy focused on changes in bone turnover, current data demonstrate that abnormalities in skeletal mineralization are also prevalent in pediatric chronic kidney disease (CKD) and likely contribute to skeletal morbidities that continue to plague this popula...

journal_title：Current osteoporosis reports

authors： Wesseling-Perry K

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In addition to the actions of the endocrine hormone, 1alpha,25-dihydroxyvitamin D (1,25(OH)2D) in stimulating intestinal calcium absorption, the regulation of bone mineral metabolism by 1,25(OH)2D is also considered an important contributor to calcium homeostasis. However, recent evidence suggest that...

journal_title：Current osteoporosis reports

authors： Anderson PH

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL), and has emerged as an important novel therapy for skeletal disorders. This article examines the use of denosumab in children. RECENT FINDINGS:Considerable safety and efficacy data exists for denosumab treatment ...

journal_title：Current osteoporosis reports

authors： Boyce AM

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs). RECENT FINDINGS:The results show that the physical and chemical properties of the nanomaterials are suitable f...

journal_title：Current osteoporosis reports

authors： de Carvalho JO,de Carvalho Oliveira F,Freitas SAP,Soares LM,de Cássia Barros Lima R,de Sousa Gonçalves L,Webster TJ,Marciano FR,Lobo AO

更新日期：2018-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The aims of this review are to summarize current performance for osteoporosis quality measures used by Centers for Medicare and Medicaid (CMS) for pay-for-performance programs and to describe recent quality improvement strategies around these measures. RECENT FINDINGS:Healthcare Effectiveness Data an...

journal_title：Current osteoporosis reports

authors： French S,Choden S,Schmajuk G

更新日期：2019-12-01 00:00:00

abstract：:Osteoporotic fractures result in significant morbidity and mortality. Anabolic agents reverse the negative skeletal balance that characterizes osteoporosis by stimulating osteoblast-dependent bone formation to a greater degree than osteoclast-dependent bone resorption. Parathyroid hormone (PTH) and parathyroid hormone...

journal_title：Current osteoporosis reports

authors： Augustine M,Horwitz MJ

更新日期：2013-12-01 00:00:00

abstract：:Understanding of osteoclast formation and activation has advanced considerably since the discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem cells express receptor activator of NF-jB ligand (RANKL), which binds to its receptor, RANK, on the surface of osteoclasts and their precursors....

journal_title：Current osteoporosis reports

authors： Boyce BF,Xing L

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteocytes comprise > 95% of the cellular component in bone tissue and produce a wide range of cytokines and cellular signaling molecules in response to mechanical stimuli. In this review, we aimed to summarize the molecular mechanisms involved in the osteocyte-mediated translation of mechanical stimu...

journal_title：Current osteoporosis reports

authors： Yan Y,Wang L,Ge L,Pathak JL

更新日期：2020-02-01 00:00:00

abstract：:Vitamin D, acting through its active metabolite 1,25(OH)(2)D(3), exerts its influence on many physiologic processes in addition to the regulation of calcium and phosphate homeostasis. These processes include the immune system. Both the adaptive and innate immune systems are affected by 1,25(OH)(2)D(3) and its receptor...

journal_title：Current osteoporosis reports

authors： Bikle DD

更新日期：2009-07-01 00:00:00

abstract：:Stem cells differ from other cells of the body in their potential for multilineage differentiation and their continued proliferation without substantial loss of potential (so-called self-renewal). These properties are maintained and regulated by a specific microenvironment referred to as "niche." This term has been us...

journal_title：Current osteoporosis reports

authors： Isern J,Méndez-Ferrer S

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Authors review the safety and efficacy of romosozumab for the treatment of osteoporosis as demonstrated in three phase III clinical trials and offer insights into the potential cardiovascular risk associated with its use. RECENT FINDINGS:Incidence of new vertebral fracture is dramatically reduced wit...

journal_title：Current osteoporosis reports

authors： Fixen C,Tunoa J

更新日期：2021-01-07 00:00:00

abstract：:The musculoskeletal system is a complex organ comprised of the skeletal bones, skeletal muscles, tendons, ligaments, cartilage, joints, and other connective tissue that physically and mechanically interact to provide animals and humans with the essential ability of locomotion. This mechanical interaction is undoubtedl...

journal_title：Current osteoporosis reports

authors： Brotto M,Johnson ML

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:One aim in bone tissue engineering is to develop human cell-based, 3D in vitro bone models to study bone physiology and pathology. Due to the heterogeneity of cells among patients, patient's own cells are needed to be obtained, ideally, from one single cell source. This review attempts to identify the...

journal_title：Current osteoporosis reports

authors： Ansari S,Ito K,Hofmann S

更新日期：2021-01-15 00:00:00

abstract：PURPOSE OF REVIEW:Fractures of osteoporotic bone in elderly individuals need special attention. This manuscript reviews the current strategies to provide sufficient fracture fixation stability with a particular focus on fractures that frequently occur in elderly individuals with osteoporosis and require full load-beari...

journal_title：Current osteoporosis reports

authors： Hollensteiner M,Sandriesser S,Bliven E,von Rüden C,Augat P

更新日期：2019-12-01 00:00:00