Abstract:
PURPOSE OF REVIEW:This study aims to describe bone marrow fat changes in diabetes and to discuss the potential role of marrow fat in skeletal fragility. RECENT FINDINGS:Advances in non-invasive imaging have facilitated marrow fat research in humans. In contrast to animal studies which clearly demonstrate higher levels of marrow fat in diabetes, human studies have shown smaller and less certain differences. Marrow fat has been reported to correlate with A1c, and there may be a distinct marrow lipid saturation profile in diabetes. Greater marrow fat is associated with impaired skeletal health. Marrow fat may be a mediator of skeletal fragility in diabetes. Circulating lipids, growth hormone alterations, visceral adiposity, and hypoleptinemia have been associated with greater marrow fat and may represent potential mechanisms for the putative effects of diabetes on marrow fat, although other factors likely contribute. Additional research is needed to further define the role of marrow fat in diabetic skeletal fragility and to determine whether marrow fat is a therapeutic target.
journal_name
Curr Osteoporos Repjournal_title
Current osteoporosis reportsauthors
Kim TY,Schafer ALdoi
10.1007/s11914-016-0336-xsubject
Has Abstractpub_date
2016-12-01 00:00:00pages
337-344issue
6eissn
1544-1873issn
1544-2241pii
10.1007/s11914-016-0336-xjournal_volume
14pub_type
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