Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain.

abstract：:Establishing a Fracture Liaison Service (FLS) to identify and treat patients with a recent fragility fracture has been shown to be effective, save money, useful to document high quality of care, and makes good clinical sense. A FLS starts with an osteoporosis champion and encompasses identification of patients with a ...

journal_title：Current osteoporosis reports

authors： Curtis JR,Silverman SL

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This paper describes recent advances in understanding the mechanisms that drive fracture pain and how these findings are helping develop new therapies to treat fracture pain. RECENT FINDINGS:Immediately following fracture, mechanosensitive nerve fibers that innervate bone are mechanically distorted. ...

journal_title：Current osteoporosis reports

authors： Mitchell SAT,Majuta LA,Mantyh PW

更新日期：2018-08-01 00:00:00

abstract：:The occurrence of a fragility fracture is an opportunity to recognize osteoporosis and begin treatment to reduce the risk of another fracture. However, selecting the treatment may have an impact on the incident fracture and this requires careful consideration of the patient and the treatment choices. There is no conse...

journal_title：Current osteoporosis reports

authors： Tanner SB

更新日期：2011-09-01 00:00:00

abstract：:Based on spiral 3D tomography a large variety of applications have been developed during the last decade to asses bone mineral density, bone macro and micro structure, and bone strength. Quantitative computed tomography (QCT) using clinical whole body scanners provides separate assessment of trabecular, cortical, and ...

journal_title：Current osteoporosis reports

authors： Engelke K,Libanati C,Fuerst T,Zysset P,Genant HK

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The age-related loss of skeletal muscle and bone tissue decreases functionality and increases the risk for falls and injuries. One contributing factor of muscle and bone loss over time is chronic low-grade inflammation. Exercise training is an effective countermeasure for decreasing the loss of muscle...

journal_title：Current osteoporosis reports

authors： Cornish SM,Chilibeck PD,Candow DG

更新日期：2020-08-01 00:00:00

abstract：:A prior fracture is a well-documented risk factor for a subsequent fracture and it doubles the risk of subsequent fractures. Few studies have investigated the time that elapses between the initial and subsequent fracture. These studies show that the subsequent fracture risk is not constant, but fluctuates over time. T...

journal_title：Current osteoporosis reports

authors： van Geel TA,Huntjens KM,van den Bergh JP,Dinant GJ,Geusens PP

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Here, we overview the latest findings from studies investigating the skeletal endocannabinoid (EC) system and its involvement in bone formation and resorption. RECENT FINDINGS:The endocannabinoid system consists of endogenous ligands, receptors, and enzymes. The main cannabinoids found in the cannabi...

journal_title：Current osteoporosis reports

authors： Raphael-Mizrahi B,Gabet Y

更新日期：2020-10-01 00:00:00

abstract：:Surrogate markers in clinical medicine provide a useful means to assess therapeutic response to pharmacologic therapy in a wide range of chronic disease states. In the area of osteoporosis, the surrogate markers of change in bone mineral density (BMD) and bone turnover markers (BTM) provide the clinician with a means ...

journal_title：Current osteoporosis reports

authors： Miller PD

更新日期：2005-09-01 00:00:00

abstract：:Caloric restriction caused by undernutrition or over-exercise is increasingly common and has significant health consequences such as hypothalamic amenorrhea, infertility, attainment of low peak bone mass, and bone loss leading to fracture. In these patients, the pathophysiology of amenorrhea and bone loss is multifact...

journal_title：Current osteoporosis reports

authors： Fenichel RM,Warren MP

更新日期：2007-12-01 00:00:00

abstract：:The greatest cause of preventable morbidity and mortality is smoking, and one of the often-underappreciated effects of smoking is profound bone loss. The existing clinical paradigm for smoking is that there is a low turnover osteoporosis. This review highlights findings from recent clinical trials and animal research ...

journal_title：Current osteoporosis reports

authors： Yan C,Avadhani NG,Iqbal J

更新日期：2011-12-01 00:00:00

abstract：:Understanding of osteoclast formation and activation has advanced considerably since the discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem cells express receptor activator of NF-jB ligand (RANKL), which binds to its receptor, RANK, on the surface of osteoclasts and their precursors....

journal_title：Current osteoporosis reports

authors： Boyce BF,Xing L

更新日期：2007-09-01 00:00:00

abstract：:Osteoporosis in men is an unrecognized but growing problem as the number of men who live to old age increases. The 10-year fracture risk at age 50 quadruples by age 80, and in general the incidence rate of osteoporotic fracture in men is about half that of women. Of note, the mortality and morbidity after hip fracture...

journal_title：Current osteoporosis reports

authors： Adler RA

更新日期：2006-09-01 00:00:00

abstract：:Statistical models (SMs) of shape (SSM) and appearance (SAM) have been acquiring popularity in medical image analysis since they were introduced in the early 1990s. They have been primarily used for segmentation, but they are also a powerful tool for 3D reconstruction and classification. All these tasks may be require...

journal_title：Current osteoporosis reports

authors： Castro-Mateos I,Pozo JM,Cootes TF,Wilkinson JM,Eastell R,Frangi AF

更新日期：2014-06-01 00:00:00

abstract：:Atraumatic fractures of the skeleton in osteoporotic patients are directly related to a deterioration of bone strength. However, the failure of the bone tissue to withstand functional load bearing cannot be explained as a simple decrease in bone mineral density (quantity); strength is also significantly dependent upon...

journal_title：Current osteoporosis reports

authors： Judex S,Boyd S,Qin YX,Miller L,Müller R,Rubin C

更新日期：2003-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review critiques the ability of CT-based methods to predict incident hip and vertebral fractures. RECENT FINDINGS:CT-based techniques with concurrent calibration all show strong associations with incident hip and vertebral fracture, predicting hip and vertebral fractures as well as, and sometime...

journal_title：Current osteoporosis reports

authors： Johannesdottir F,Allaire B,Bouxsein ML

更新日期：2018-08-01 00:00:00

abstract：:Low vitamin D status, which is endemic due to inadequate oral intake combined with sun avoidance, contributes to musculoskeletal and other pathologies. Although controversial, it is increasingly recommended that serum 25-hydroxyvitamin D (25D) concentrations less than 30 ng/mL be considered suboptimal. Clinicians shou...

journal_title：Current osteoporosis reports

authors： Binkley N,Krueger D

更新日期：2008-09-01 00:00:00

abstract：:The musculoskeletal system is a complex organ comprised of the skeletal bones, skeletal muscles, tendons, ligaments, cartilage, joints, and other connective tissue that physically and mechanically interact to provide animals and humans with the essential ability of locomotion. This mechanical interaction is undoubtedl...

journal_title：Current osteoporosis reports

authors： Brotto M,Johnson ML

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs). RECENT FINDINGS:The results show that the physical and chemical properties of the nanomaterials are suitable f...

journal_title：Current osteoporosis reports

authors： de Carvalho JO,de Carvalho Oliveira F,Freitas SAP,Soares LM,de Cássia Barros Lima R,de Sousa Gonçalves L,Webster TJ,Marciano FR,Lobo AO

更新日期：2018-10-01 00:00:00

abstract：:Musculoskeletal diseases are highly prevalent with staggering annual health care costs across the globe. The combined wasting of muscle (sarcopenia) and bone (osteoporosis)-both in normal aging and pathologic states-can lead to vastly compounded risk for fracture in patients. Until now, our therapeutic approach to the...

journal_title：Current osteoporosis reports

authors： Girgis CM,Mokbel N,Digirolamo DJ

更新日期：2014-06-01 00:00:00

abstract：:The past decade has seen a significant expansion of our understanding of the interaction between the neural system and bone. While innervation of bone was long appreciated, the discovery of central relays from the hypothalamus to the cells of bone has seen the identification of a number of efferent neural pathways to ...

journal_title：Current osteoporosis reports

authors： Khor EC,Baldock P

更新日期：2012-06-01 00:00:00

abstract：:The pediatric origin of osteoporosis has led many investigators to focus on determining factors that influence bone gain during growth and methods for optimizing this gain. Bone responds to bone loading activities by increasing mass or size. Overall, pediatric studies have found a positive effect of bone loading on bo...

journal_title：Current osteoporosis reports

authors： Specker B,Minett M

更新日期：2013-09-01 00:00:00

abstract：:Nutritional status is an essential component in determining whole body energy homeostasis. The balance between energy/food intake and metabolism is governed by a range of hormones secreted from various parts of the body. Their subsequent dissemination via the blood results in a wide range of biological responses inclu...

journal_title：Current osteoporosis reports

authors： Khor EC,Wee NK,Baldock PA

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:One aim in bone tissue engineering is to develop human cell-based, 3D in vitro bone models to study bone physiology and pathology. Due to the heterogeneity of cells among patients, patient's own cells are needed to be obtained, ideally, from one single cell source. This review attempts to identify the...

journal_title：Current osteoporosis reports

authors： Ansari S,Ito K,Hofmann S

更新日期：2021-01-15 00:00:00

abstract：PURPOSE OF REVIEW:Novel therapies for damaged and diseased bone are being developed in a preclinical testing process consisting of in vitro cell experiments followed by in vivo animal studies. The in vitro results are often not representative of the results observed in vivo. This could be caused by the complexity of th...

journal_title：Current osteoporosis reports

authors： Cramer EEA,Ito K,Hofmann S

更新日期：2021-01-11 00:00:00

abstract：:Frailty is highly prevalent in the elderly, increasing the risk of poor outcomes that include falls, incident disability, hospitalization, and mortality. Thus, a great need exists to characterize the underlying mechanisms and ultimately identify strategies that prevent, delay, and even reverse frailty. Mouse models ca...

journal_title：Current osteoporosis reports

authors： Seldeen KL,Pang M,Troen BR

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:We give an update on the etiology and potential treatment options of rare inherited monogenic disorders associated with arterial calcification and calcific cardiac valve disease. RECENT FINDINGS:Genetic studies of rare inherited syndromes have identified key regulators of ectopic calcification. Based...

journal_title：Current osteoporosis reports

authors： Nitschke Y,Rutsch F

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:In addition to the actions of the endocrine hormone, 1alpha,25-dihydroxyvitamin D (1,25(OH)2D) in stimulating intestinal calcium absorption, the regulation of bone mineral metabolism by 1,25(OH)2D is also considered an important contributor to calcium homeostasis. However, recent evidence suggest that...

journal_title：Current osteoporosis reports

authors： Anderson PH

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review was to compile a list of tools currently available to study bone cells and in particular osteocytes. As the interest (and importance) in osteocyte biology has greatly expanded over the past decade, new tools and techniques have become available to study these elusive cells, RECE...

journal_title：Current osteoporosis reports

authors： Divieti Pajevic P

更新日期：2020-10-01 00:00:00

abstract：:Calcium is the dominant mineral in bone and is a shortfall nutrient in the diet. For those consuming inadequate dietary calcium, calcium supplements have been a standard strategy for prevention of osteoporosis. Recently, calcium supplementation has been linked to both increased and decreased cardiovascular disease ris...

journal_title：Current osteoporosis reports

authors： Weaver CM

更新日期：2014-06-01 00:00:00

abstract：:The postmenopausal state is the most common underlying cause for osteoporosis and most of our understanding of the condition relates to this group. Recent evidence has suggested that hormone therapy may no longer have the pre-eminent place it once held but the same studies have also confirmed its antifracture efficacy...

journal_title：Current osteoporosis reports

authors： Selby P

更新日期：2004-09-01 00:00:00