The role of microbial biofilms in osteonecrosis of the jaw associated with bisphosphonate therapy.

abstract：PURPOSE OF REVIEW:We give an update on the etiology and potential treatment options of rare inherited monogenic disorders associated with arterial calcification and calcific cardiac valve disease. RECENT FINDINGS:Genetic studies of rare inherited syndromes have identified key regulators of ectopic calcification. Based...

journal_title：Current osteoporosis reports

authors： Nitschke Y,Rutsch F

更新日期：2017-08-01 00:00:00

abstract：:Although vitamin D is used mainly as a nutritional supplement in osteoporosis treatment, its active form, 1,25-dihydroxyvitamin D [1,25(OH)(2)D], has an effect to maintain bone remodeling balance as well. Eldecalcitol is an analog of 1,25(OH) (2)D(3) with stronger effects than its native form in improving bone remodel...

journal_title：Current osteoporosis reports

authors： Matsumoto T

更新日期：2012-12-01 00:00:00

abstract：:The pediatric origin of osteoporosis has led many investigators to focus on determining factors that influence bone gain during growth and methods for optimizing this gain. Bone responds to bone loading activities by increasing mass or size. Overall, pediatric studies have found a positive effect of bone loading on bo...

journal_title：Current osteoporosis reports

authors： Specker B,Minett M

更新日期：2013-09-01 00:00:00

abstract：:Musculoskeletal pain disorders are the second largest contributor to global disability underlining the significance of effective treatments. However, treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in particular, is challenging as the underlying peripheral and central pain mechanism...

journal_title：Current osteoporosis reports

authors： Arendt-Nielsen L,Skou ST,Nielsen TA,Petersen KK

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteogenesis is a complex process involving the specification of multiple progenitor cells and their maturation and differentiation into matrix-secreting osteoblasts. Osteogenesis occurs not only during embryogenesis but also during growth, after an injury, and in normal homeostatic maintenance. While...

journal_title：Current osteoporosis reports

authors： Sera SR,Zur Nieden NI

更新日期：2017-08-01 00:00:00

abstract：:Many orthobiologic adjuvants are available and widely utilized for general skeletal restoration. Their use for the specific task of osteoporotic fracture augmentation is less well recognized. Common conductive materials are reviewed for their value in this patient population including the large group of allograft adju...

journal_title：Current osteoporosis reports

authors： Watson JT,Nicolaou DA

更新日期：2015-02-01 00:00:00

abstract：:Osteoporosis presents a dilemma for the orthopedic surgeon. Screw fixation within the bone is crucial for mechanical stabilization, maintenance of reduction, and ultimately, fracture healing. For the patient, soft bones and physiological fragility usually benefit from immediate weight bearing and mobility to avoid fur...

journal_title：Current osteoporosis reports

authors： Jones CB

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this paper is to review state-of-the-art transcriptome profiling methods and their recent applications in the field of skeletal biology. RECENT FINDINGS:Next-generation sequencing of mRNA (RNA-seq) methods have been established and routinely used in skeletal biology research. RNA-seq has ...

journal_title：Current osteoporosis reports

authors： Ayturk U

更新日期：2019-08-01 00:00:00

abstract：:Understanding of osteoclast formation and activation has advanced considerably since the discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem cells express receptor activator of NF-jB ligand (RANKL), which binds to its receptor, RANK, on the surface of osteoclasts and their precursors....

journal_title：Current osteoporosis reports

authors： Boyce BF,Xing L

更新日期：2007-09-01 00:00:00

abstract：:Microcrack accumulation in cortical bone has been implicated in skeletal fragility and stress fractures. These cracks have also been shown to affect the mechanical and material properties of cortical bone. Their growth has been linked to osteocyte apoptosis and the initiation of the remodeling process, which also has ...

journal_title：Current osteoporosis reports

authors： O'Brien FJ,Brennan O,Kennedy OD,Lee TC

更新日期：2005-06-01 00:00:00

abstract：:The musculoskeletal system is a complex organ comprised of the skeletal bones, skeletal muscles, tendons, ligaments, cartilage, joints, and other connective tissue that physically and mechanically interact to provide animals and humans with the essential ability of locomotion. This mechanical interaction is undoubtedl...

journal_title：Current osteoporosis reports

authors： Brotto M,Johnson ML

更新日期：2014-06-01 00:00:00

abstract：:Caloric restriction caused by undernutrition or over-exercise is increasingly common and has significant health consequences such as hypothalamic amenorrhea, infertility, attainment of low peak bone mass, and bone loss leading to fracture. In these patients, the pathophysiology of amenorrhea and bone loss is multifact...

journal_title：Current osteoporosis reports

authors： Fenichel RM,Warren MP

更新日期：2007-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Neurogenic heterotopic ossification (NHO) is the abnormal formation of extra-skeletal bones in periarticular muscles after damage to the central nervous system (CNS) such as spinal cord injury (SCI), traumatic brain injury (TBI), stroke, or cerebral anoxia. The purpose of this review is to summarize r...

journal_title：Current osteoporosis reports

authors： Alexander KA,Tseng HW,Salga M,Genêt F,Levesque JP

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This paper describes recent advances in understanding the mechanisms that drive fracture pain and how these findings are helping develop new therapies to treat fracture pain. RECENT FINDINGS:Immediately following fracture, mechanosensitive nerve fibers that innervate bone are mechanically distorted. ...

journal_title：Current osteoporosis reports

authors： Mitchell SAT,Majuta LA,Mantyh PW

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Novel therapies for damaged and diseased bone are being developed in a preclinical testing process consisting of in vitro cell experiments followed by in vivo animal studies. The in vitro results are often not representative of the results observed in vivo. This could be caused by the complexity of th...

journal_title：Current osteoporosis reports

authors： Cramer EEA,Ito K,Hofmann S

更新日期：2021-01-11 00:00:00

abstract：PURPOSE OF REVIEW:Authors review the safety and efficacy of romosozumab for the treatment of osteoporosis as demonstrated in three phase III clinical trials and offer insights into the potential cardiovascular risk associated with its use. RECENT FINDINGS:Incidence of new vertebral fracture is dramatically reduced wit...

journal_title：Current osteoporosis reports

authors： Fixen C,Tunoa J

更新日期：2021-01-07 00:00:00

abstract：:Based on spiral 3D tomography a large variety of applications have been developed during the last decade to asses bone mineral density, bone macro and micro structure, and bone strength. Quantitative computed tomography (QCT) using clinical whole body scanners provides separate assessment of trabecular, cortical, and ...

journal_title：Current osteoporosis reports

authors： Engelke K,Libanati C,Fuerst T,Zysset P,Genant HK

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteocytes comprise > 95% of the cellular component in bone tissue and produce a wide range of cytokines and cellular signaling molecules in response to mechanical stimuli. In this review, we aimed to summarize the molecular mechanisms involved in the osteocyte-mediated translation of mechanical stimu...

journal_title：Current osteoporosis reports

authors： Yan Y,Wang L,Ge L,Pathak JL

更新日期：2020-02-01 00:00:00

abstract：:There is an increasing repertoire of laboratory tests available for assessing the bone remodeling process. Biochemical markers of bone remodeling can be measured in serum or urine, and have a number of potential roles in the management of fracture risk. Differences in remodeling between individuals might be related to...

journal_title：Current osteoporosis reports

authors： Blumsohn A

更新日期：2003-12-01 00:00:00

abstract：:Because there are now effective agents for treatment of osteoporosis, the question is being raised as to whether or not it is ethical to have placebo-controlled trials of new agents. It is ethical for patients who are at low risk of serious or irreversible harm to participate in placebo-controlled trials as long as th...

journal_title：Current osteoporosis reports

authors： Watts NB

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review outlines the recent findings regarding the impact of bariatric surgery on bone. It explores potential mechanisms for skeletal changes following bariatric surgery and strategies for management. RECENT FINDINGS:Bone loss following bariatric surgery is multifactorial. Probable mechanisms inc...

journal_title：Current osteoporosis reports

authors： Krez AN,Stein EM

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review was to compile a list of tools currently available to study bone cells and in particular osteocytes. As the interest (and importance) in osteocyte biology has greatly expanded over the past decade, new tools and techniques have become available to study these elusive cells, RECE...

journal_title：Current osteoporosis reports

authors： Divieti Pajevic P

更新日期：2020-10-01 00:00:00

abstract：:Osteoporosis in men is an unrecognized but growing problem as the number of men who live to old age increases. The 10-year fracture risk at age 50 quadruples by age 80, and in general the incidence rate of osteoporotic fracture in men is about half that of women. Of note, the mortality and morbidity after hip fracture...

journal_title：Current osteoporosis reports

authors： Adler RA

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:One aim in bone tissue engineering is to develop human cell-based, 3D in vitro bone models to study bone physiology and pathology. Due to the heterogeneity of cells among patients, patient's own cells are needed to be obtained, ideally, from one single cell source. This review attempts to identify the...

journal_title：Current osteoporosis reports

authors： Ansari S,Ito K,Hofmann S

更新日期：2021-01-15 00:00:00

abstract：PURPOSE OF REVIEW:Fractures of osteoporotic bone in elderly individuals need special attention. This manuscript reviews the current strategies to provide sufficient fracture fixation stability with a particular focus on fractures that frequently occur in elderly individuals with osteoporosis and require full load-beari...

journal_title：Current osteoporosis reports

authors： Hollensteiner M,Sandriesser S,Bliven E,von Rüden C,Augat P

更新日期：2019-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This study aims to describe bone marrow fat changes in diabetes and to discuss the potential role of marrow fat in skeletal fragility. RECENT FINDINGS:Advances in non-invasive imaging have facilitated marrow fat research in humans. In contrast to animal studies which clearly demonstrate higher levels...

journal_title：Current osteoporosis reports

authors： Kim TY,Schafer AL

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL), and has emerged as an important novel therapy for skeletal disorders. This article examines the use of denosumab in children. RECENT FINDINGS:Considerable safety and efficacy data exists for denosumab treatment ...

journal_title：Current osteoporosis reports

authors： Boyce AM

更新日期：2017-08-01 00:00:00

abstract：:A prior fracture is a well-documented risk factor for a subsequent fracture and it doubles the risk of subsequent fractures. Few studies have investigated the time that elapses between the initial and subsequent fracture. These studies show that the subsequent fracture risk is not constant, but fluctuates over time. T...

journal_title：Current osteoporosis reports

authors： van Geel TA,Huntjens KM,van den Bergh JP,Dinant GJ,Geusens PP

更新日期：2010-09-01 00:00:00

abstract：:As the population with HIV continues to age, specialists in HIV care are increasingly encountering chronic health conditions, which now include osteoporosis, osteopenia, and fragility fractures. The pathophysiology of the bone effects of HIV infection is complex and includes traditional risk factors for bone loss as w...

journal_title：Current osteoporosis reports

authors： Rothman MS,Bessesen MT

更新日期：2012-12-01 00:00:00

abstract：:Establishing a Fracture Liaison Service (FLS) to identify and treat patients with a recent fragility fracture has been shown to be effective, save money, useful to document high quality of care, and makes good clinical sense. A FLS starts with an osteoporosis champion and encompasses identification of patients with a ...

journal_title：Current osteoporosis reports

authors： Curtis JR,Silverman SL

更新日期：2013-12-01 00:00:00