Abstract：
PURPOSE OF REVIEW:Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL), and has emerged as an important novel therapy for skeletal disorders. This article examines the use of denosumab in children. RECENT FINDINGS:Considerable safety and efficacy data exists for denosumab treatment of adults with osteoporosis, bone metastases, and giant cell tumors. Pediatric data is limited; however, evidence suggests denosumab may be beneficial in decreasing bone turnover, increasing bone density, and preventing growth of certain skeletal neoplasms in children. Denosumab's effect on bone turnover is rapidly reversible after drug discontinuation, representing a key difference from bisphosphonates. Rebound increased bone turnover has led to severe hypercalcemia in several pediatric patients. Denosumab is a promising therapy for pediatric skeletal disorders. At present, safety concerns related to rebounding bone turnover and mineral homeostasis impact use of denosumab in children. Research is needed to determine if and how these effects can be mitigated.
journal_name
Curr Osteoporos Repjournal_title
Current osteoporosis reportsauthors
Boyce AMdoi
10.1007/s11914-017-0380-1subject
Has Abstractpub_date
2017-08-01 00:00:00pages
283-292issue
4eissn
1544-1873issn
1544-2241pii
10.1007/s11914-017-0380-1journal_volume
15pub_type
杂志文章,评审abstract：:Osteoporotic fractures result in significant morbidity and mortality. Anabolic agents reverse the negative skeletal balance that characterizes osteoporosis by stimulating osteoblast-dependent bone formation to a greater degree than osteoclast-dependent bone resorption. Parathyroid hormone (PTH) and parathyroid hormone...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-013-0171-2
更新日期：2013-12-01 00:00:00
abstract：:Microbial biofilms have been observed and described in bone specimens of patients with bisphosphonate (BP)-associated osteonecrosis of the jaw (BONJ) and investigators are more recently suggesting that this condition essentially represents an osteomyelitis of the jaw clinically, with greater susceptibility in some pat...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-010-0008-1
更新日期：2010-03-01 00:00:00
abstract：:In a previous version of this publication, the author Mercedes Rodriguez Celin's name was listed as M.R. Celin. ...
journal_title：Current osteoporosis reports
pub_type： 已发布勘误
doi：10.1007/s11914-020-00637-9
更新日期：2020-10-29 00:00:00
abstract：PURPOSE OF REVIEW:The goal of the review is to summarize the current knowledge on the process of chondrocyte-to-osteoblast transdifferentiation during endochondral bone formation and its potential implications in fracture healing and disease. RECENT FINDINGS:Lineage tracing experiments confirmed the transdifferentiati...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00511-3
更新日期：2019-06-01 00:00:00
abstract：:Musculoskeletal pain disorders are the second largest contributor to global disability underlining the significance of effective treatments. However, treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in particular, is challenging as the underlying peripheral and central pain mechanism...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-015-0276-x
更新日期：2015-08-01 00:00:00
abstract：:Although vitamin D is used mainly as a nutritional supplement in osteoporosis treatment, its active form, 1,25-dihydroxyvitamin D [1,25(OH)(2)D], has an effect to maintain bone remodeling balance as well. Eldecalcitol is an analog of 1,25(OH) (2)D(3) with stronger effects than its native form in improving bone remodel...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-012-0116-1
更新日期：2012-12-01 00:00:00
abstract：:Bone metastasis is a deadly complication of cancers arising from many different primary tumor locations. Cross talk between cancer and bone cells is a well-established driver of bone metastasis, and recent work reveals microRNA (miRNA) as key players in this communication. Functional significance of miRNA was first de...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-016-0316-1
更新日期：2016-10-01 00:00:00
abstract：PURPOSE OF REVIEW:This study aims to describe bone marrow fat changes in diabetes and to discuss the potential role of marrow fat in skeletal fragility. RECENT FINDINGS:Advances in non-invasive imaging have facilitated marrow fat research in humans. In contrast to animal studies which clearly demonstrate higher levels...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-016-0336-x
更新日期：2016-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The aims of this review are to summarize current performance for osteoporosis quality measures used by Centers for Medicare and Medicaid (CMS) for pay-for-performance programs and to describe recent quality improvement strategies around these measures. RECENT FINDINGS:Healthcare Effectiveness Data an...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00547-5
更新日期：2019-12-01 00:00:00
abstract：:As the population with HIV continues to age, specialists in HIV care are increasingly encountering chronic health conditions, which now include osteoporosis, osteopenia, and fragility fractures. The pathophysiology of the bone effects of HIV infection is complex and includes traditional risk factors for bone loss as w...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-012-0125-0
更新日期：2012-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The goal of this paper is to review state-of-the-art transcriptome profiling methods and their recent applications in the field of skeletal biology. RECENT FINDINGS:Next-generation sequencing of mRNA (RNA-seq) methods have been established and routinely used in skeletal biology research. RNA-seq has ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00517-x
更新日期：2019-08-01 00:00:00
abstract：:There is an increasing repertoire of laboratory tests available for assessing the bone remodeling process. Biochemical markers of bone remodeling can be measured in serum or urine, and have a number of potential roles in the management of fracture risk. Differences in remodeling between individuals might be related to...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-996-0002-9
更新日期：2003-12-01 00:00:00
abstract：:Understanding of osteoclast formation and activation has advanced considerably since the discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem cells express receptor activator of NF-jB ligand (RANKL), which binds to its receptor, RANK, on the surface of osteoclasts and their precursors....
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-007-0024-y
更新日期：2007-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Here, we overview the latest findings from studies investigating the skeletal endocannabinoid (EC) system and its involvement in bone formation and resorption. RECENT FINDINGS:The endocannabinoid system consists of endogenous ligands, receptors, and enzymes. The main cannabinoids found in the cannabi...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00607-1
更新日期：2020-10-01 00:00:00
abstract：PURPOSE OF REVIEW:In addition to the actions of the endocrine hormone, 1alpha,25-dihydroxyvitamin D (1,25(OH)2D) in stimulating intestinal calcium absorption, the regulation of bone mineral metabolism by 1,25(OH)2D is also considered an important contributor to calcium homeostasis. However, recent evidence suggest that...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-017-0394-8
更新日期：2017-10-01 00:00:00
abstract：:Musculoskeletal diseases are highly prevalent with staggering annual health care costs across the globe. The combined wasting of muscle (sarcopenia) and bone (osteoporosis)-both in normal aging and pathologic states-can lead to vastly compounded risk for fracture in patients. Until now, our therapeutic approach to the...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0204-5
更新日期：2014-06-01 00:00:00
abstract：:Establishing a Fracture Liaison Service (FLS) to identify and treat patients with a recent fragility fracture has been shown to be effective, save money, useful to document high quality of care, and makes good clinical sense. A FLS starts with an osteoporosis champion and encompasses identification of patients with a ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-013-0177-9
更新日期：2013-12-01 00:00:00
abstract：:Caloric restriction caused by undernutrition or over-exercise is increasingly common and has significant health consequences such as hypothalamic amenorrhea, infertility, attainment of low peak bone mass, and bone loss leading to fracture. In these patients, the pathophysiology of amenorrhea and bone loss is multifact...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-007-0011-3
更新日期：2007-12-01 00:00:00
abstract：:Frailty is highly prevalent in the elderly, increasing the risk of poor outcomes that include falls, incident disability, hospitalization, and mortality. Thus, a great need exists to characterize the underlying mechanisms and ultimately identify strategies that prevent, delay, and even reverse frailty. Mouse models ca...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-015-0283-y
更新日期：2015-10-01 00:00:00
abstract：:Statistical models (SMs) of shape (SSM) and appearance (SAM) have been acquiring popularity in medical image analysis since they were introduced in the early 1990s. They have been primarily used for segmentation, but they are also a powerful tool for 3D reconstruction and classification. All these tasks may be require...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0206-3
更新日期：2014-06-01 00:00:00
abstract：:Substantial evidence exists that in addition to the well-known complications of diabetes, increased fracture risk is an important morbidity. This risk is probably due, at least in part, to altered bone remodeling and bone cell function in diabetes. Circulating biochemical markers of bone formation, including P1NP, ost...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-015-0265-0
更新日期：2015-06-01 00:00:00
abstract：PURPOSE OF THIS REVIEW:The goal of the review is to provide an updated understanding of the pathophysiology of glucocorticoid-induced osteoporosis and treatment recommendations. RECENT FINDINGS:Glucocorticoids reduce osteoblast and osteocyte lifespan and activity and reduce the vascularity of the bone that together ma...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00498-x
更新日期：2019-02-01 00:00:00
abstract：PURPOSE OF REVIEW:The aim of this review was to compile a list of tools currently available to study bone cells and in particular osteocytes. As the interest (and importance) in osteocyte biology has greatly expanded over the past decade, new tools and techniques have become available to study these elusive cells, RECE...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00613-3
更新日期：2020-10-01 00:00:00
abstract：PURPOSE OF REVIEW:To summarize reports published since the 2013 American Society of Bone and Mineral Research Task Force Report on atypical femoral fractures (AFF). RECENT FINDINGS:The absolute incidence of AFFs remains low. AFFs are primarily associated with prolonged bisphosphonate (BP) exposure, but have also been ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-018-0464-6
更新日期：2018-08-01 00:00:00
abstract：PURPOSE OF REVIEW:We give an update on the etiology and potential treatment options of rare inherited monogenic disorders associated with arterial calcification and calcific cardiac valve disease. RECENT FINDINGS:Genetic studies of rare inherited syndromes have identified key regulators of ectopic calcification. Based...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-017-0370-3
更新日期：2017-08-01 00:00:00
abstract：PURPOSE OF REVIEW:To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs). RECENT FINDINGS:The results show that the physical and chemical properties of the nanomaterials are suitable f...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-018-0476-2
更新日期：2018-10-01 00:00:00
abstract：:The musculoskeletal system is a complex organ comprised of the skeletal bones, skeletal muscles, tendons, ligaments, cartilage, joints, and other connective tissue that physically and mechanically interact to provide animals and humans with the essential ability of locomotion. This mechanical interaction is undoubtedl...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0209-0
更新日期：2014-06-01 00:00:00
abstract：PURPOSE OF REVIEW:This review critiques the ability of CT-based methods to predict incident hip and vertebral fractures. RECENT FINDINGS:CT-based techniques with concurrent calibration all show strong associations with incident hip and vertebral fracture, predicting hip and vertebral fractures as well as, and sometime...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-018-0450-z
更新日期：2018-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Neurogenic heterotopic ossification (NHO) is the abnormal formation of extra-skeletal bones in periarticular muscles after damage to the central nervous system (CNS) such as spinal cord injury (SCI), traumatic brain injury (TBI), stroke, or cerebral anoxia. The purpose of this review is to summarize r...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00636-w
更新日期：2020-12-01 00:00:00
abstract：:Calcium is the dominant mineral in bone and is a shortfall nutrient in the diet. For those consuming inadequate dietary calcium, calcium supplements have been a standard strategy for prevention of osteoporosis. Recently, calcium supplementation has been linked to both increased and decreased cardiovascular disease ris...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0208-1
更新日期：2014-06-01 00:00:00
