Abstract:
:A prior fracture is a well-documented risk factor for a subsequent fracture and it doubles the risk of subsequent fractures. Few studies have investigated the time that elapses between the initial and subsequent fracture. These studies show that the subsequent fracture risk is not constant, but fluctuates over time. The risk of subsequent vertebral, hip, and nonvertebral non-hip fractures is highest immediately after initial hip, clinical, and radiographic vertebral fractures and nonvertebral fractures and declines afterward, regardless of gender, age, and initial fracture location. These studies indicate the need for early action after an initial fracture with medical interventions that have an effect within a short term to reduce the preventable risks of subsequent fractures.
journal_name
Curr Osteoporos Repjournal_title
Current osteoporosis reportsauthors
van Geel TA,Huntjens KM,van den Bergh JP,Dinant GJ,Geusens PPdoi
10.1007/s11914-010-0023-2subject
Has Abstractpub_date
2010-09-01 00:00:00pages
118-22issue
3eissn
1544-1873issn
1544-2241journal_volume
8pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:We outline the diverse processes contributing to bone mineralization and bone matrix maturation by describing two mouse models with bone strength defects caused by restricted deletion of the receptor tyrosine kinase ligand EphrinB2. RECENT FINDINGS:Stage-specific EphrinB2 deletion differs in its effe...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-019-00524-y
更新日期:2019-10-01 00:00:00
abstract:PURPOSE OF THIS REVIEW:The goal of the review is to provide an updated understanding of the pathophysiology of glucocorticoid-induced osteoporosis and treatment recommendations. RECENT FINDINGS:Glucocorticoids reduce osteoblast and osteocyte lifespan and activity and reduce the vascularity of the bone that together ma...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-019-00498-x
更新日期:2019-02-01 00:00:00
abstract::Statistical models (SMs) of shape (SSM) and appearance (SAM) have been acquiring popularity in medical image analysis since they were introduced in the early 1990s. They have been primarily used for segmentation, but they are also a powerful tool for 3D reconstruction and classification. All these tasks may be require...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-014-0206-3
更新日期:2014-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Identifying individuals at high fracture risk can be used to target those likely to derive the greatest benefit from treatment. This narrative review examines recent developments in using specific risk factors used to assess fracture risk, with a focus on publications in the last 3 years. RECENT FIND...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-020-00590-7
更新日期:2020-06-01 00:00:00
abstract::Based on spiral 3D tomography a large variety of applications have been developed during the last decade to asses bone mineral density, bone macro and micro structure, and bone strength. Quantitative computed tomography (QCT) using clinical whole body scanners provides separate assessment of trabecular, cortical, and ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-013-0147-2
更新日期:2013-09-01 00:00:00
abstract::Nutritional status is an essential component in determining whole body energy homeostasis. The balance between energy/food intake and metabolism is governed by a range of hormones secreted from various parts of the body. Their subsequent dissemination via the blood results in a wide range of biological responses inclu...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-013-0157-0
更新日期:2013-09-01 00:00:00
abstract::The musculoskeletal system is a complex organ comprised of the skeletal bones, skeletal muscles, tendons, ligaments, cartilage, joints, and other connective tissue that physically and mechanically interact to provide animals and humans with the essential ability of locomotion. This mechanical interaction is undoubtedl...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-014-0209-0
更新日期:2014-06-01 00:00:00
abstract::Osteoporosis is characterized by the occurrence of a host of fractures. According to densitometric values, an operational definition for osteoporosis corresponds to a loss of 25% to 30% (-2.5 T-scores) compared with the mean values of bone mineral density of young premenopausal women. For years, research tried to deve...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-010-0024-1
更新日期:2010-09-01 00:00:00
abstract::The occurrence of a fragility fracture is an opportunity to recognize osteoporosis and begin treatment to reduce the risk of another fracture. However, selecting the treatment may have an impact on the incident fracture and this requires careful consideration of the patient and the treatment choices. There is no conse...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-011-0061-4
更新日期:2011-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The goal of this paper is to review state-of-the-art transcriptome profiling methods and their recent applications in the field of skeletal biology. RECENT FINDINGS:Next-generation sequencing of mRNA (RNA-seq) methods have been established and routinely used in skeletal biology research. RNA-seq has ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-019-00517-x
更新日期:2019-08-01 00:00:00
abstract::The past decade has seen a significant expansion of our understanding of the interaction between the neural system and bone. While innervation of bone was long appreciated, the discovery of central relays from the hypothalamus to the cells of bone has seen the identification of a number of efferent neural pathways to ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-012-0102-7
更新日期:2012-06-01 00:00:00
abstract::Microbial biofilms have been observed and described in bone specimens of patients with bisphosphonate (BP)-associated osteonecrosis of the jaw (BONJ) and investigators are more recently suggesting that this condition essentially represents an osteomyelitis of the jaw clinically, with greater susceptibility in some pat...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-010-0008-1
更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The aims of this review are to summarize current performance for osteoporosis quality measures used by Centers for Medicare and Medicaid (CMS) for pay-for-performance programs and to describe recent quality improvement strategies around these measures. RECENT FINDINGS:Healthcare Effectiveness Data an...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-019-00547-5
更新日期:2019-12-01 00:00:00
abstract::Understanding of osteoclast formation and activation has advanced considerably since the discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem cells express receptor activator of NF-jB ligand (RANKL), which binds to its receptor, RANK, on the surface of osteoclasts and their precursors....
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-007-0024-y
更新日期:2007-09-01 00:00:00
abstract::Intercellular communication within the bone microenvironment is critical for the maintenance of normal bone structure. Osteoblast-lineage cells at all stages of differentiation, from pluripotent precursors to matrix-embedded osteocytes, produce regulatory factors that modulate the differentiation and activity of both ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-012-0096-1
更新日期:2012-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Diabetes has a detrimental effect on bone, increasing the risk of fracture and formation of osteolytic lesions such as those seen in periodontitis. Several diabetic complications are caused by diabetes-enhanced inflammation. This review examines mechanisms by which IL-17 contributes to diabetes-enhanc...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-020-00559-6
更新日期:2020-02-01 00:00:00
abstract::Metabolic bone disease is a major public health concern, especially when it manifests as hip fracture which carries significant morbidity and mortality. Individuals with neurological disease are at higher risk of osteopenia, osteoporosis and fragility fracture compared to age-matched controls, yet this is under-apprec...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-016-0320-5
更新日期:2016-10-01 00:00:00
abstract::Frailty is highly prevalent in the elderly, increasing the risk of poor outcomes that include falls, incident disability, hospitalization, and mortality. Thus, a great need exists to characterize the underlying mechanisms and ultimately identify strategies that prevent, delay, and even reverse frailty. Mouse models ca...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-015-0283-y
更新日期:2015-10-01 00:00:00
abstract::Vitamin D, acting through its active metabolite 1,25(OH)(2)D(3), exerts its influence on many physiologic processes in addition to the regulation of calcium and phosphate homeostasis. These processes include the immune system. Both the adaptive and innate immune systems are affected by 1,25(OH)(2)D(3) and its receptor...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-009-0011-6
更新日期:2009-07-01 00:00:00
abstract::Many orthobiologic adjuvants are available and widely utilized for general skeletal restoration. Their use for the specific task of osteoporotic fracture augmentation is less well recognized. Common conductive materials are reviewed for their value in this patient population including the large group of allograft adju...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-014-0249-5
更新日期:2015-02-01 00:00:00
abstract::Stem cells differ from other cells of the body in their potential for multilineage differentiation and their continued proliferation without substantial loss of potential (so-called self-renewal). These properties are maintained and regulated by a specific microenvironment referred to as "niche." This term has been us...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-011-0075-y
更新日期:2011-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The goal of the review is to summarize the current knowledge on the process of chondrocyte-to-osteoblast transdifferentiation during endochondral bone formation and its potential implications in fracture healing and disease. RECENT FINDINGS:Lineage tracing experiments confirmed the transdifferentiati...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-019-00511-3
更新日期:2019-06-01 00:00:00
abstract::The pediatric origin of osteoporosis has led many investigators to focus on determining factors that influence bone gain during growth and methods for optimizing this gain. Bone responds to bone loading activities by increasing mass or size. Overall, pediatric studies have found a positive effect of bone loading on bo...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-013-0152-5
更新日期:2013-09-01 00:00:00
abstract::Although vitamin D is used mainly as a nutritional supplement in osteoporosis treatment, its active form, 1,25-dihydroxyvitamin D [1,25(OH)(2)D], has an effect to maintain bone remodeling balance as well. Eldecalcitol is an analog of 1,25(OH) (2)D(3) with stronger effects than its native form in improving bone remodel...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-012-0116-1
更新日期:2012-12-01 00:00:00
abstract::Substantial evidence exists that in addition to the well-known complications of diabetes, increased fracture risk is an important morbidity. This risk is probably due, at least in part, to altered bone remodeling and bone cell function in diabetes. Circulating biochemical markers of bone formation, including P1NP, ost...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-015-0265-0
更新日期:2015-06-01 00:00:00
abstract::Because there are now effective agents for treatment of osteoporosis, the question is being raised as to whether or not it is ethical to have placebo-controlled trials of new agents. It is ethical for patients who are at low risk of serious or irreversible harm to participate in placebo-controlled trials as long as th...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-004-0012-4
更新日期:2004-03-01 00:00:00
abstract::Musculoskeletal diseases are highly prevalent with staggering annual health care costs across the globe. The combined wasting of muscle (sarcopenia) and bone (osteoporosis)-both in normal aging and pathologic states-can lead to vastly compounded risk for fracture in patients. Until now, our therapeutic approach to the...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-014-0204-5
更新日期:2014-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Osteogenesis is a complex process involving the specification of multiple progenitor cells and their maturation and differentiation into matrix-secreting osteoblasts. Osteogenesis occurs not only during embryogenesis but also during growth, after an injury, and in normal homeostatic maintenance. While...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-017-0379-7
更新日期:2017-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The age-related loss of skeletal muscle and bone tissue decreases functionality and increases the risk for falls and injuries. One contributing factor of muscle and bone loss over time is chronic low-grade inflammation. Exercise training is an effective countermeasure for decreasing the loss of muscle...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-020-00596-1
更新日期:2020-08-01 00:00:00
abstract:PURPOSE OF REVIEW:This review outlines the recent findings regarding the impact of bariatric surgery on bone. It explores potential mechanisms for skeletal changes following bariatric surgery and strategies for management. RECENT FINDINGS:Bone loss following bariatric surgery is multifactorial. Probable mechanisms inc...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-020-00579-2
更新日期:2020-06-01 00:00:00