Abstract：
PURPOSE OF REVIEW:The age-related loss of skeletal muscle and bone tissue decreases functionality and increases the risk for falls and injuries. One contributing factor of muscle and bone loss over time is chronic low-grade inflammation. Exercise training is an effective countermeasure for decreasing the loss of muscle and bone tissue, possibly by enhancing immune system response. Herein, we discuss key interactions between the immune system, muscle, and bone in relation to exercise perturbations, and we identify that there is substantial "cross-talk" between muscle and bone and the immune system in response to exercise. RECENT FINDINGS:Recent advances in our understanding of the "cross-talk" between muscle and bone and the immune system indicate that exercise is likely to mediate many of the beneficial effects on muscle and bone via their interactions with the immune system. The age-related loss of muscle and bone tissue may be partially explained by an impaired immune system via chronic low-grade inflammation. Exercise training has a beneficial effect on immune system function and aging muscle and bone. Theoretically, the "cross-talk" between the immune system, muscle, and bone in response to exercise enhances aging musculoskeletal health.
journal_name
Curr Osteoporos Repjournal_title
Current osteoporosis reportsauthors
Cornish SM,Chilibeck PD,Candow DGdoi
10.1007/s11914-020-00596-1subject
Has Abstractpub_date
2020-08-01 00:00:00pages
350-356issue
4eissn
1544-1873issn
1544-2241pii
10.1007/s11914-020-00596-1journal_volume
18pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:In addition to the actions of the endocrine hormone, 1alpha,25-dihydroxyvitamin D (1,25(OH)2D) in stimulating intestinal calcium absorption, the regulation of bone mineral metabolism by 1,25(OH)2D is also considered an important contributor to calcium homeostasis. However, recent evidence suggest that...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-017-0394-8
更新日期：2017-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Mechanical loading is an essential stimulus for skeletal tissues. Osteocytes are primarily responsible for sensing mechanical stimuli in bone and for orchestrating subsequent responses. This is critical for maintaining homeostasis, and responding to injury/disease. The osteocyte mechanotransduction pa...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-018-0485-1
更新日期：2018-12-01 00:00:00
abstract：:Osteocytes, the most abundant cell type in bone, remain the least characterized. Several theories have been proposed regarding their function, including osteolysis, sensing the strains produced in response to mechanical loading of bones, and producing signals that affect the function of osteoblasts and osteoclasts and...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-007-0007-z
更新日期：2007-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL), and has emerged as an important novel therapy for skeletal disorders. This article examines the use of denosumab in children. RECENT FINDINGS:Considerable safety and efficacy data exists for denosumab treatment ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-017-0380-1
更新日期：2017-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Here, we overview the latest findings from studies investigating the skeletal endocannabinoid (EC) system and its involvement in bone formation and resorption. RECENT FINDINGS:The endocannabinoid system consists of endogenous ligands, receptors, and enzymes. The main cannabinoids found in the cannabi...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00607-1
更新日期：2020-10-01 00:00:00
abstract：PURPOSE OF THIS REVIEW:The goal of the review is to provide an updated understanding of the pathophysiology of glucocorticoid-induced osteoporosis and treatment recommendations. RECENT FINDINGS:Glucocorticoids reduce osteoblast and osteocyte lifespan and activity and reduce the vascularity of the bone that together ma...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00498-x
更新日期：2019-02-01 00:00:00
abstract：PURPOSE OF REVIEW:This paper describes recent advances in understanding the mechanisms that drive fracture pain and how these findings are helping develop new therapies to treat fracture pain. RECENT FINDINGS:Immediately following fracture, mechanosensitive nerve fibers that innervate bone are mechanically distorted. ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-018-0446-8
更新日期：2018-08-01 00:00:00
abstract：:Low vitamin D status, which is endemic due to inadequate oral intake combined with sun avoidance, contributes to musculoskeletal and other pathologies. Although controversial, it is increasingly recommended that serum 25-hydroxyvitamin D (25D) concentrations less than 30 ng/mL be considered suboptimal. Clinicians shou...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-008-0017-5
更新日期：2008-09-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to explore the role of monocyte chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone remodelling, particularly the action of osteoblasts and osteoclasts, and its role in the development and metastasis of cancers that target the bone. RECENT FINDI...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00545-7
更新日期：2019-12-01 00:00:00
abstract：:The greatest cause of preventable morbidity and mortality is smoking, and one of the often-underappreciated effects of smoking is profound bone loss. The existing clinical paradigm for smoking is that there is a low turnover osteoporosis. This review highlights findings from recent clinical trials and animal research ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-011-0068-x
更新日期：2011-12-01 00:00:00
abstract：:Caloric restriction caused by undernutrition or over-exercise is increasingly common and has significant health consequences such as hypothalamic amenorrhea, infertility, attainment of low peak bone mass, and bone loss leading to fracture. In these patients, the pathophysiology of amenorrhea and bone loss is multifact...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-007-0011-3
更新日期：2007-12-01 00:00:00
abstract：:The occurrence of a fragility fracture is an opportunity to recognize osteoporosis and begin treatment to reduce the risk of another fracture. However, selecting the treatment may have an impact on the incident fracture and this requires careful consideration of the patient and the treatment choices. There is no conse...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-011-0061-4
更新日期：2011-09-01 00:00:00
abstract：:Vitamin D, acting through its active metabolite 1,25(OH)(2)D(3), exerts its influence on many physiologic processes in addition to the regulation of calcium and phosphate homeostasis. These processes include the immune system. Both the adaptive and innate immune systems are affected by 1,25(OH)(2)D(3) and its receptor...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-009-0011-6
更新日期：2009-07-01 00:00:00
abstract：:Understanding of osteoclast formation and activation has advanced considerably since the discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem cells express receptor activator of NF-jB ligand (RANKL), which binds to its receptor, RANK, on the surface of osteoclasts and their precursors....
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-007-0024-y
更新日期：2007-09-01 00:00:00
abstract：PURPOSE OF REVIEW:To summarize reports published since the 2013 American Society of Bone and Mineral Research Task Force Report on atypical femoral fractures (AFF). RECENT FINDINGS:The absolute incidence of AFFs remains low. AFFs are primarily associated with prolonged bisphosphonate (BP) exposure, but have also been ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-018-0464-6
更新日期：2018-08-01 00:00:00
abstract：:Surrogate markers in clinical medicine provide a useful means to assess therapeutic response to pharmacologic therapy in a wide range of chronic disease states. In the area of osteoporosis, the surrogate markers of change in bone mineral density (BMD) and bone turnover markers (BTM) provide the clinician with a means ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-005-0018-6
更新日期：2005-09-01 00:00:00
abstract：:Stem cells differ from other cells of the body in their potential for multilineage differentiation and their continued proliferation without substantial loss of potential (so-called self-renewal). These properties are maintained and regulated by a specific microenvironment referred to as "niche." This term has been us...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-011-0075-y
更新日期：2011-12-01 00:00:00
abstract：:Statistical models (SMs) of shape (SSM) and appearance (SAM) have been acquiring popularity in medical image analysis since they were introduced in the early 1990s. They have been primarily used for segmentation, but they are also a powerful tool for 3D reconstruction and classification. All these tasks may be require...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0206-3
更新日期：2014-06-01 00:00:00
abstract：:Osteoporosis presents a dilemma for the orthopedic surgeon. Screw fixation within the bone is crucial for mechanical stabilization, maintenance of reduction, and ultimately, fracture healing. For the patient, soft bones and physiological fragility usually benefit from immediate weight bearing and mobility to avoid fur...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-012-0124-1
更新日期：2012-12-01 00:00:00
abstract：:Calcium is the dominant mineral in bone and is a shortfall nutrient in the diet. For those consuming inadequate dietary calcium, calcium supplements have been a standard strategy for prevention of osteoporosis. Recently, calcium supplementation has been linked to both increased and decreased cardiovascular disease ris...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0208-1
更新日期：2014-06-01 00:00:00
abstract：PURPOSE OF REVIEW:This study aims to describe bone marrow fat changes in diabetes and to discuss the potential role of marrow fat in skeletal fragility. RECENT FINDINGS:Advances in non-invasive imaging have facilitated marrow fat research in humans. In contrast to animal studies which clearly demonstrate higher levels...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-016-0336-x
更新日期：2016-12-01 00:00:00
abstract：:Metabolic bone disease is a major public health concern, especially when it manifests as hip fracture which carries significant morbidity and mortality. Individuals with neurological disease are at higher risk of osteopenia, osteoporosis and fragility fracture compared to age-matched controls, yet this is under-apprec...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-016-0320-5
更新日期：2016-10-01 00:00:00
abstract：:Although traditional diagnosis and treatment of renal osteodystrophy focused on changes in bone turnover, current data demonstrate that abnormalities in skeletal mineralization are also prevalent in pediatric chronic kidney disease (CKD) and likely contribute to skeletal morbidities that continue to plague this popula...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-015-0253-4
更新日期：2015-04-01 00:00:00
abstract：:Atraumatic fractures of the skeleton in osteoporotic patients are directly related to a deterioration of bone strength. However, the failure of the bone tissue to withstand functional load bearing cannot be explained as a simple decrease in bone mineral density (quantity); strength is also significantly dependent upon...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-003-0003-x
更新日期：2003-06-01 00:00:00
abstract：PURPOSE OF REVIEW:We outline the diverse processes contributing to bone mineralization and bone matrix maturation by describing two mouse models with bone strength defects caused by restricted deletion of the receptor tyrosine kinase ligand EphrinB2. RECENT FINDINGS:Stage-specific EphrinB2 deletion differs in its effe...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00524-y
更新日期：2019-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Osteogenesis is a complex process involving the specification of multiple progenitor cells and their maturation and differentiation into matrix-secreting osteoblasts. Osteogenesis occurs not only during embryogenesis but also during growth, after an injury, and in normal homeostatic maintenance. While...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-017-0379-7
更新日期：2017-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Diabetes has a detrimental effect on bone, increasing the risk of fracture and formation of osteolytic lesions such as those seen in periodontitis. Several diabetic complications are caused by diabetes-enhanced inflammation. This review examines mechanisms by which IL-17 contributes to diabetes-enhanc...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00559-6
更新日期：2020-02-01 00:00:00
abstract：:Many orthobiologic adjuvants are available and widely utilized for general skeletal restoration. Their use for the specific task of osteoporotic fracture augmentation is less well recognized. Common conductive materials are reviewed for their value in this patient population including the large group of allograft adju...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0249-5
更新日期：2015-02-01 00:00:00
abstract：PURPOSE OF REVIEW:The aims of this review are to summarize current performance for osteoporosis quality measures used by Centers for Medicare and Medicaid (CMS) for pay-for-performance programs and to describe recent quality improvement strategies around these measures. RECENT FINDINGS:Healthcare Effectiveness Data an...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00547-5
更新日期：2019-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Novel therapies for damaged and diseased bone are being developed in a preclinical testing process consisting of in vitro cell experiments followed by in vivo animal studies. The in vitro results are often not representative of the results observed in vivo. This could be caused by the complexity of th...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00649-5
更新日期：2021-01-11 00:00:00
