Abstract：
:Nutritional status is an essential component in determining whole body energy homeostasis. The balance between energy/food intake and metabolism is governed by a range of hormones secreted from various parts of the body. Their subsequent dissemination via the blood results in a wide range of biological responses including satiety, hunger, and glucose uptake. The roles of these systemic hormones also extend to bone regulation with animal and clinical studies establishing a relationship between these regulatory pathways. This review covers the gastrointestinal hormones, ghrelin, PYY, GIP, GLP-1, and GLP-2, and the adipokines, leptin, and adiponectin and their roles in regulating bone homeostasis. Their known actions are reviewed, with an emphasis upon recent advances in understanding. Taken together, this review outlines an expanding appreciation of the interactions between bone mass and the nutritional control of whole body energy balance by gut and adipose tissue.
journal_name
Curr Osteoporos Repjournal_title
Current osteoporosis reportsauthors
Khor EC,Wee NK,Baldock PAdoi
10.1007/s11914-013-0157-0subject
Has Abstractpub_date
2013-09-01 00:00:00pages
194-202issue
3eissn
1544-1873issn
1544-2241journal_volume
11pub_type
杂志文章,评审abstract：:Microcrack accumulation in cortical bone has been implicated in skeletal fragility and stress fractures. These cracks have also been shown to affect the mechanical and material properties of cortical bone. Their growth has been linked to osteocyte apoptosis and the initiation of the remodeling process, which also has ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-005-0002-1
更新日期：2005-06-01 00:00:00
abstract：:A prior fracture is a well-documented risk factor for a subsequent fracture and it doubles the risk of subsequent fractures. Few studies have investigated the time that elapses between the initial and subsequent fracture. These studies show that the subsequent fracture risk is not constant, but fluctuates over time. T...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-010-0023-2
更新日期：2010-09-01 00:00:00
abstract：:Many orthobiologic adjuvants are available and widely utilized for general skeletal restoration. Their use for the specific task of osteoporotic fracture augmentation is less well recognized. Common conductive materials are reviewed for their value in this patient population including the large group of allograft adju...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0249-5
更新日期：2015-02-01 00:00:00
abstract：:Substantial evidence exists that in addition to the well-known complications of diabetes, increased fracture risk is an important morbidity. This risk is probably due, at least in part, to altered bone remodeling and bone cell function in diabetes. Circulating biochemical markers of bone formation, including P1NP, ost...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-015-0265-0
更新日期：2015-06-01 00:00:00
abstract：:As the population with HIV continues to age, specialists in HIV care are increasingly encountering chronic health conditions, which now include osteoporosis, osteopenia, and fragility fractures. The pathophysiology of the bone effects of HIV infection is complex and includes traditional risk factors for bone loss as w...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-012-0125-0
更新日期：2012-12-01 00:00:00
abstract：:Vitamin D, acting through its active metabolite 1,25(OH)(2)D(3), exerts its influence on many physiologic processes in addition to the regulation of calcium and phosphate homeostasis. These processes include the immune system. Both the adaptive and innate immune systems are affected by 1,25(OH)(2)D(3) and its receptor...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-009-0011-6
更新日期：2009-07-01 00:00:00
abstract：PURPOSE OF REVIEW:This study aims to describe bone marrow fat changes in diabetes and to discuss the potential role of marrow fat in skeletal fragility. RECENT FINDINGS:Advances in non-invasive imaging have facilitated marrow fat research in humans. In contrast to animal studies which clearly demonstrate higher levels...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-016-0336-x
更新日期：2016-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Identifying individuals at high fracture risk can be used to target those likely to derive the greatest benefit from treatment. This narrative review examines recent developments in using specific risk factors used to assess fracture risk, with a focus on publications in the last 3 years. RECENT FIND...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00590-7
更新日期：2020-06-01 00:00:00
abstract：:In a previous version of this publication, the author Mercedes Rodriguez Celin's name was listed as M.R. Celin. ...
journal_title：Current osteoporosis reports
pub_type： 已发布勘误
doi：10.1007/s11914-020-00637-9
更新日期：2020-10-29 00:00:00
abstract：:Statistical models (SMs) of shape (SSM) and appearance (SAM) have been acquiring popularity in medical image analysis since they were introduced in the early 1990s. They have been primarily used for segmentation, but they are also a powerful tool for 3D reconstruction and classification. All these tasks may be require...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0206-3
更新日期：2014-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The goal of this paper is to review state-of-the-art transcriptome profiling methods and their recent applications in the field of skeletal biology. RECENT FINDINGS:Next-generation sequencing of mRNA (RNA-seq) methods have been established and routinely used in skeletal biology research. RNA-seq has ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00517-x
更新日期：2019-08-01 00:00:00
abstract：PURPOSE OF REVIEW:To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs). RECENT FINDINGS:The results show that the physical and chemical properties of the nanomaterials are suitable f...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-018-0476-2
更新日期：2018-10-01 00:00:00
abstract：:The pediatric origin of osteoporosis has led many investigators to focus on determining factors that influence bone gain during growth and methods for optimizing this gain. Bone responds to bone loading activities by increasing mass or size. Overall, pediatric studies have found a positive effect of bone loading on bo...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-013-0152-5
更新日期：2013-09-01 00:00:00
abstract：:Osteoporosis presents a dilemma for the orthopedic surgeon. Screw fixation within the bone is crucial for mechanical stabilization, maintenance of reduction, and ultimately, fracture healing. For the patient, soft bones and physiological fragility usually benefit from immediate weight bearing and mobility to avoid fur...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-012-0124-1
更新日期：2012-12-01 00:00:00
abstract：:Calcium is the dominant mineral in bone and is a shortfall nutrient in the diet. For those consuming inadequate dietary calcium, calcium supplements have been a standard strategy for prevention of osteoporosis. Recently, calcium supplementation has been linked to both increased and decreased cardiovascular disease ris...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0208-1
更新日期：2014-06-01 00:00:00
abstract：:Intercellular communication within the bone microenvironment is critical for the maintenance of normal bone structure. Osteoblast-lineage cells at all stages of differentiation, from pluripotent precursors to matrix-embedded osteocytes, produce regulatory factors that modulate the differentiation and activity of both ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-012-0096-1
更新日期：2012-06-01 00:00:00
abstract：PURPOSE OF REVIEW:This review outlines the recent findings regarding the impact of bariatric surgery on bone. It explores potential mechanisms for skeletal changes following bariatric surgery and strategies for management. RECENT FINDINGS:Bone loss following bariatric surgery is multifactorial. Probable mechanisms inc...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00579-2
更新日期：2020-06-01 00:00:00
abstract：:Understanding of osteoclast formation and activation has advanced considerably since the discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem cells express receptor activator of NF-jB ligand (RANKL), which binds to its receptor, RANK, on the surface of osteoclasts and their precursors....
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-007-0024-y
更新日期：2007-09-01 00:00:00
abstract：:Low vitamin D status, which is endemic due to inadequate oral intake combined with sun avoidance, contributes to musculoskeletal and other pathologies. Although controversial, it is increasingly recommended that serum 25-hydroxyvitamin D (25D) concentrations less than 30 ng/mL be considered suboptimal. Clinicians shou...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-008-0017-5
更新日期：2008-09-01 00:00:00
abstract：PURPOSE OF REVIEW:One aim in bone tissue engineering is to develop human cell-based, 3D in vitro bone models to study bone physiology and pathology. Due to the heterogeneity of cells among patients, patient's own cells are needed to be obtained, ideally, from one single cell source. This review attempts to identify the...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00648-6
更新日期：2021-01-15 00:00:00
abstract：:Because there are now effective agents for treatment of osteoporosis, the question is being raised as to whether or not it is ethical to have placebo-controlled trials of new agents. It is ethical for patients who are at low risk of serious or irreversible harm to participate in placebo-controlled trials as long as th...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-004-0012-4
更新日期：2004-03-01 00:00:00
abstract：:Surrogate markers in clinical medicine provide a useful means to assess therapeutic response to pharmacologic therapy in a wide range of chronic disease states. In the area of osteoporosis, the surrogate markers of change in bone mineral density (BMD) and bone turnover markers (BTM) provide the clinician with a means ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-005-0018-6
更新日期：2005-09-01 00:00:00
abstract：:Osteoporosis in men is an unrecognized but growing problem as the number of men who live to old age increases. The 10-year fracture risk at age 50 quadruples by age 80, and in general the incidence rate of osteoporotic fracture in men is about half that of women. Of note, the mortality and morbidity after hip fracture...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-996-0030-5
更新日期：2006-09-01 00:00:00
abstract：:Osteoporosis is characterized by the occurrence of a host of fractures. According to densitometric values, an operational definition for osteoporosis corresponds to a loss of 25% to 30% (-2.5 T-scores) compared with the mean values of bone mineral density of young premenopausal women. For years, research tried to deve...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-010-0024-1
更新日期：2010-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Novel therapies for damaged and diseased bone are being developed in a preclinical testing process consisting of in vitro cell experiments followed by in vivo animal studies. The in vitro results are often not representative of the results observed in vivo. This could be caused by the complexity of th...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00649-5
更新日期：2021-01-11 00:00:00
abstract：PURPOSE OF REVIEW:Here, we overview the latest findings from studies investigating the skeletal endocannabinoid (EC) system and its involvement in bone formation and resorption. RECENT FINDINGS:The endocannabinoid system consists of endogenous ligands, receptors, and enzymes. The main cannabinoids found in the cannabi...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00607-1
更新日期：2020-10-01 00:00:00
abstract：:The occurrence of a fragility fracture is an opportunity to recognize osteoporosis and begin treatment to reduce the risk of another fracture. However, selecting the treatment may have an impact on the incident fracture and this requires careful consideration of the patient and the treatment choices. There is no conse...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-011-0061-4
更新日期：2011-09-01 00:00:00
abstract：:Although vitamin D is used mainly as a nutritional supplement in osteoporosis treatment, its active form, 1,25-dihydroxyvitamin D [1,25(OH)(2)D], has an effect to maintain bone remodeling balance as well. Eldecalcitol is an analog of 1,25(OH) (2)D(3) with stronger effects than its native form in improving bone remodel...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-012-0116-1
更新日期：2012-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Fractures of osteoporotic bone in elderly individuals need special attention. This manuscript reviews the current strategies to provide sufficient fracture fixation stability with a particular focus on fractures that frequently occur in elderly individuals with osteoporosis and require full load-beari...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00535-9
更新日期：2019-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The aims of this review are to summarize current performance for osteoporosis quality measures used by Centers for Medicare and Medicaid (CMS) for pay-for-performance programs and to describe recent quality improvement strategies around these measures. RECENT FINDINGS:Healthcare Effectiveness Data an...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00547-5
更新日期：2019-12-01 00:00:00
