Carbon Nanomaterials for Treating Osteoporotic Vertebral Fractures.

abstract：PURPOSE OF REVIEW:The goal of this paper is to review state-of-the-art transcriptome profiling methods and their recent applications in the field of skeletal biology. RECENT FINDINGS:Next-generation sequencing of mRNA (RNA-seq) methods have been established and routinely used in skeletal biology research. RNA-seq has ...

journal_title：Current osteoporosis reports

authors： Ayturk U

更新日期：2019-08-01 00:00:00

abstract：:Nutritional status is an essential component in determining whole body energy homeostasis. The balance between energy/food intake and metabolism is governed by a range of hormones secreted from various parts of the body. Their subsequent dissemination via the blood results in a wide range of biological responses inclu...

journal_title：Current osteoporosis reports

authors： Khor EC,Wee NK,Baldock PA

更新日期：2013-09-01 00:00:00

abstract：:The pediatric origin of osteoporosis has led many investigators to focus on determining factors that influence bone gain during growth and methods for optimizing this gain. Bone responds to bone loading activities by increasing mass or size. Overall, pediatric studies have found a positive effect of bone loading on bo...

journal_title：Current osteoporosis reports

authors： Specker B,Minett M

更新日期：2013-09-01 00:00:00

abstract：:Although substantial increases in survival rates among children diagnosed with cancer have been observed in recent decades, survivors are at risk of developing therapy-related chronic health conditions. Among children and adolescents treated for cancer, acquisition of peak bone mass may be compromised by cancer therap...

journal_title：Current osteoporosis reports

authors： Wilson CL,Ness KK

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Fractures of osteoporotic bone in elderly individuals need special attention. This manuscript reviews the current strategies to provide sufficient fracture fixation stability with a particular focus on fractures that frequently occur in elderly individuals with osteoporosis and require full load-beari...

journal_title：Current osteoporosis reports

authors： Hollensteiner M,Sandriesser S,Bliven E,von Rüden C,Augat P

更新日期：2019-12-01 00:00:00

abstract：:Osteoporotic fractures result in significant morbidity and mortality. Anabolic agents reverse the negative skeletal balance that characterizes osteoporosis by stimulating osteoblast-dependent bone formation to a greater degree than osteoclast-dependent bone resorption. Parathyroid hormone (PTH) and parathyroid hormone...

journal_title：Current osteoporosis reports

authors： Augustine M,Horwitz MJ

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Mechanical loading is an essential stimulus for skeletal tissues. Osteocytes are primarily responsible for sensing mechanical stimuli in bone and for orchestrating subsequent responses. This is critical for maintaining homeostasis, and responding to injury/disease. The osteocyte mechanotransduction pa...

journal_title：Current osteoporosis reports

authors： Hinton PV,Rackard SM,Kennedy OD

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review critiques the ability of CT-based methods to predict incident hip and vertebral fractures. RECENT FINDINGS:CT-based techniques with concurrent calibration all show strong associations with incident hip and vertebral fracture, predicting hip and vertebral fractures as well as, and sometime...

journal_title：Current osteoporosis reports

authors： Johannesdottir F,Allaire B,Bouxsein ML

更新日期：2018-08-01 00:00:00

abstract：:Understanding of osteoclast formation and activation has advanced considerably since the discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem cells express receptor activator of NF-jB ligand (RANKL), which binds to its receptor, RANK, on the surface of osteoclasts and their precursors....

journal_title：Current osteoporosis reports

authors： Boyce BF,Xing L

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:We give an update on the etiology and potential treatment options of rare inherited monogenic disorders associated with arterial calcification and calcific cardiac valve disease. RECENT FINDINGS:Genetic studies of rare inherited syndromes have identified key regulators of ectopic calcification. Based...

journal_title：Current osteoporosis reports

authors： Nitschke Y,Rutsch F

更新日期：2017-08-01 00:00:00

abstract：:The occurrence of a fragility fracture is an opportunity to recognize osteoporosis and begin treatment to reduce the risk of another fracture. However, selecting the treatment may have an impact on the incident fracture and this requires careful consideration of the patient and the treatment choices. There is no conse...

journal_title：Current osteoporosis reports

authors： Tanner SB

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Novel therapies for damaged and diseased bone are being developed in a preclinical testing process consisting of in vitro cell experiments followed by in vivo animal studies. The in vitro results are often not representative of the results observed in vivo. This could be caused by the complexity of th...

journal_title：Current osteoporosis reports

authors： Cramer EEA,Ito K,Hofmann S

更新日期：2021-01-11 00:00:00

abstract：:As the population with HIV continues to age, specialists in HIV care are increasingly encountering chronic health conditions, which now include osteoporosis, osteopenia, and fragility fractures. The pathophysiology of the bone effects of HIV infection is complex and includes traditional risk factors for bone loss as w...

journal_title：Current osteoporosis reports

authors： Rothman MS,Bessesen MT

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:We outline the diverse processes contributing to bone mineralization and bone matrix maturation by describing two mouse models with bone strength defects caused by restricted deletion of the receptor tyrosine kinase ligand EphrinB2. RECENT FINDINGS:Stage-specific EphrinB2 deletion differs in its effe...

journal_title：Current osteoporosis reports

authors： Blank M,Sims NA

更新日期：2019-10-01 00:00:00

abstract：:The greatest cause of preventable morbidity and mortality is smoking, and one of the often-underappreciated effects of smoking is profound bone loss. The existing clinical paradigm for smoking is that there is a low turnover osteoporosis. This review highlights findings from recent clinical trials and animal research ...

journal_title：Current osteoporosis reports

authors： Yan C,Avadhani NG,Iqbal J

更新日期：2011-12-01 00:00:00

abstract：:Musculoskeletal pain disorders are the second largest contributor to global disability underlining the significance of effective treatments. However, treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in particular, is challenging as the underlying peripheral and central pain mechanism...

journal_title：Current osteoporosis reports

authors： Arendt-Nielsen L,Skou ST,Nielsen TA,Petersen KK

更新日期：2015-08-01 00:00:00

abstract：:Establishing a Fracture Liaison Service (FLS) to identify and treat patients with a recent fragility fracture has been shown to be effective, save money, useful to document high quality of care, and makes good clinical sense. A FLS starts with an osteoporosis champion and encompasses identification of patients with a ...

journal_title：Current osteoporosis reports

authors： Curtis JR,Silverman SL

更新日期：2013-12-01 00:00:00

abstract：:Osteoporosis in men is an unrecognized but growing problem as the number of men who live to old age increases. The 10-year fracture risk at age 50 quadruples by age 80, and in general the incidence rate of osteoporotic fracture in men is about half that of women. Of note, the mortality and morbidity after hip fracture...

journal_title：Current osteoporosis reports

authors： Adler RA

更新日期：2006-09-01 00:00:00

abstract：:Calcium is the dominant mineral in bone and is a shortfall nutrient in the diet. For those consuming inadequate dietary calcium, calcium supplements have been a standard strategy for prevention of osteoporosis. Recently, calcium supplementation has been linked to both increased and decreased cardiovascular disease ris...

journal_title：Current osteoporosis reports

authors： Weaver CM

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:In addition to the actions of the endocrine hormone, 1alpha,25-dihydroxyvitamin D (1,25(OH)2D) in stimulating intestinal calcium absorption, the regulation of bone mineral metabolism by 1,25(OH)2D is also considered an important contributor to calcium homeostasis. However, recent evidence suggest that...

journal_title：Current osteoporosis reports

authors： Anderson PH

更新日期：2017-10-01 00:00:00

abstract：:Microbial biofilms have been observed and described in bone specimens of patients with bisphosphonate (BP)-associated osteonecrosis of the jaw (BONJ) and investigators are more recently suggesting that this condition essentially represents an osteomyelitis of the jaw clinically, with greater susceptibility in some pat...

journal_title：Current osteoporosis reports

authors： Kumar SK,Gorur A,Schaudinn C,Shuler CF,Costerton JW,Sedghizadeh PP

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize reports published since the 2013 American Society of Bone and Mineral Research Task Force Report on atypical femoral fractures (AFF). RECENT FINDINGS:The absolute incidence of AFFs remains low. AFFs are primarily associated with prolonged bisphosphonate (BP) exposure, but have also been ...

journal_title：Current osteoporosis reports

authors： Starr J,Tay YKD,Shane E

更新日期：2018-08-01 00:00:00

abstract：:Metabolic bone disease is a major public health concern, especially when it manifests as hip fracture which carries significant morbidity and mortality. Individuals with neurological disease are at higher risk of osteopenia, osteoporosis and fragility fracture compared to age-matched controls, yet this is under-apprec...

journal_title：Current osteoporosis reports

authors： Binks S,Dobson R

更新日期：2016-10-01 00:00:00

abstract：:Bone metastasis is a deadly complication of cancers arising from many different primary tumor locations. Cross talk between cancer and bone cells is a well-established driver of bone metastasis, and recent work reveals microRNA (miRNA) as key players in this communication. Functional significance of miRNA was first de...

journal_title：Current osteoporosis reports

authors： Baier SR,Wan Y

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The age-related loss of skeletal muscle and bone tissue decreases functionality and increases the risk for falls and injuries. One contributing factor of muscle and bone loss over time is chronic low-grade inflammation. Exercise training is an effective countermeasure for decreasing the loss of muscle...

journal_title：Current osteoporosis reports

authors： Cornish SM,Chilibeck PD,Candow DG

更新日期：2020-08-01 00:00:00

abstract：:Based on spiral 3D tomography a large variety of applications have been developed during the last decade to asses bone mineral density, bone macro and micro structure, and bone strength. Quantitative computed tomography (QCT) using clinical whole body scanners provides separate assessment of trabecular, cortical, and ...

journal_title：Current osteoporosis reports

authors： Engelke K,Libanati C,Fuerst T,Zysset P,Genant HK

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The aims of this review are to summarize current performance for osteoporosis quality measures used by Centers for Medicare and Medicaid (CMS) for pay-for-performance programs and to describe recent quality improvement strategies around these measures. RECENT FINDINGS:Healthcare Effectiveness Data an...

journal_title：Current osteoporosis reports

authors： French S,Choden S,Schmajuk G

更新日期：2019-12-01 00:00:00

abstract：PURPOSE OF THIS REVIEW:The goal of the review is to provide an updated understanding of the pathophysiology of glucocorticoid-induced osteoporosis and treatment recommendations. RECENT FINDINGS:Glucocorticoids reduce osteoblast and osteocyte lifespan and activity and reduce the vascularity of the bone that together ma...

journal_title：Current osteoporosis reports

authors： Lane NE

更新日期：2019-02-01 00:00:00

abstract：:There is an increasing repertoire of laboratory tests available for assessing the bone remodeling process. Biochemical markers of bone remodeling can be measured in serum or urine, and have a number of potential roles in the management of fracture risk. Differences in remodeling between individuals might be related to...

journal_title：Current osteoporosis reports

authors： Blumsohn A

更新日期：2003-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review was to compile a list of tools currently available to study bone cells and in particular osteocytes. As the interest (and importance) in osteocyte biology has greatly expanded over the past decade, new tools and techniques have become available to study these elusive cells, RECE...

journal_title：Current osteoporosis reports

authors： Divieti Pajevic P

更新日期：2020-10-01 00:00:00