Abstract:
:Many orthobiologic adjuvants are available and widely utilized for general skeletal restoration. Their use for the specific task of osteoporotic fracture augmentation is less well recognized. Common conductive materials are reviewed for their value in this patient population including the large group of allograft adjuvants categorically known as the demineralized bone matrices (DBMs). Another large group of alloplastic materials is also examined-the calcium phosphate and sulfate ceramics. Both of these materials, when used for the proper indications, demonstrate efficacy for these patients. The inductive properties of bone morphogenic proteins (BMPs) and platelet concentrates show no clear advantages for this group of patients. Systemic agents including bisphosphonates, receptor activator of nuclear factor κβ ligand (RANKL) inhibitors, and parathyroid hormone augmentation all demonstrate positive effects with this fracture cohort. Newer modalities, such as trace ion bioceramic augmentation, are also reviewed for their positive effects on osteoporotic fracture healing.
journal_name
Curr Osteoporos Repjournal_title
Current osteoporosis reportsauthors
Watson JT,Nicolaou DAdoi
10.1007/s11914-014-0249-5subject
Has Abstractpub_date
2015-02-01 00:00:00pages
22-9issue
1eissn
1544-1873issn
1544-2241journal_volume
13pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:We give an update on the etiology and potential treatment options of rare inherited monogenic disorders associated with arterial calcification and calcific cardiac valve disease. RECENT FINDINGS:Genetic studies of rare inherited syndromes have identified key regulators of ectopic calcification. Based...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-017-0370-3
更新日期:2017-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Fractures of osteoporotic bone in elderly individuals need special attention. This manuscript reviews the current strategies to provide sufficient fracture fixation stability with a particular focus on fractures that frequently occur in elderly individuals with osteoporosis and require full load-beari...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-019-00535-9
更新日期:2019-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Neurogenic heterotopic ossification (NHO) is the abnormal formation of extra-skeletal bones in periarticular muscles after damage to the central nervous system (CNS) such as spinal cord injury (SCI), traumatic brain injury (TBI), stroke, or cerebral anoxia. The purpose of this review is to summarize r...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-020-00636-w
更新日期:2020-12-01 00:00:00
abstract::Stem cells differ from other cells of the body in their potential for multilineage differentiation and their continued proliferation without substantial loss of potential (so-called self-renewal). These properties are maintained and regulated by a specific microenvironment referred to as "niche." This term has been us...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-011-0075-y
更新日期:2011-12-01 00:00:00
abstract::The musculoskeletal system is a complex organ comprised of the skeletal bones, skeletal muscles, tendons, ligaments, cartilage, joints, and other connective tissue that physically and mechanically interact to provide animals and humans with the essential ability of locomotion. This mechanical interaction is undoubtedl...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-014-0209-0
更新日期:2014-06-01 00:00:00
abstract::Atraumatic fractures of the skeleton in osteoporotic patients are directly related to a deterioration of bone strength. However, the failure of the bone tissue to withstand functional load bearing cannot be explained as a simple decrease in bone mineral density (quantity); strength is also significantly dependent upon...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-003-0003-x
更新日期:2003-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This review outlines the recent findings regarding the impact of bariatric surgery on bone. It explores potential mechanisms for skeletal changes following bariatric surgery and strategies for management. RECENT FINDINGS:Bone loss following bariatric surgery is multifactorial. Probable mechanisms inc...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-020-00579-2
更新日期:2020-06-01 00:00:00
abstract::Although substantial increases in survival rates among children diagnosed with cancer have been observed in recent decades, survivors are at risk of developing therapy-related chronic health conditions. Among children and adolescents treated for cancer, acquisition of peak bone mass may be compromised by cancer therap...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-013-0165-0
更新日期:2013-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Osteogenesis is a complex process involving the specification of multiple progenitor cells and their maturation and differentiation into matrix-secreting osteoblasts. Osteogenesis occurs not only during embryogenesis but also during growth, after an injury, and in normal homeostatic maintenance. While...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-017-0379-7
更新日期:2017-08-01 00:00:00
abstract::Calcium is the dominant mineral in bone and is a shortfall nutrient in the diet. For those consuming inadequate dietary calcium, calcium supplements have been a standard strategy for prevention of osteoporosis. Recently, calcium supplementation has been linked to both increased and decreased cardiovascular disease ris...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-014-0208-1
更新日期:2014-06-01 00:00:00
abstract::Osteoporosis is characterized by the occurrence of a host of fractures. According to densitometric values, an operational definition for osteoporosis corresponds to a loss of 25% to 30% (-2.5 T-scores) compared with the mean values of bone mineral density of young premenopausal women. For years, research tried to deve...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-010-0024-1
更新日期:2010-09-01 00:00:00
abstract::Establishing a Fracture Liaison Service (FLS) to identify and treat patients with a recent fragility fracture has been shown to be effective, save money, useful to document high quality of care, and makes good clinical sense. A FLS starts with an osteoporosis champion and encompasses identification of patients with a ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-013-0177-9
更新日期:2013-12-01 00:00:00
abstract:PURPOSE OF REVIEW:One aim in bone tissue engineering is to develop human cell-based, 3D in vitro bone models to study bone physiology and pathology. Due to the heterogeneity of cells among patients, patient's own cells are needed to be obtained, ideally, from one single cell source. This review attempts to identify the...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-020-00648-6
更新日期:2021-01-15 00:00:00
abstract::Substantial evidence exists that in addition to the well-known complications of diabetes, increased fracture risk is an important morbidity. This risk is probably due, at least in part, to altered bone remodeling and bone cell function in diabetes. Circulating biochemical markers of bone formation, including P1NP, ost...
journal_title:Current osteoporosis reports
pub_type: 杂志文章
doi:10.1007/s11914-015-0265-0
更新日期:2015-06-01 00:00:00
abstract::Bone metastasis is a deadly complication of cancers arising from many different primary tumor locations. Cross talk between cancer and bone cells is a well-established driver of bone metastasis, and recent work reveals microRNA (miRNA) as key players in this communication. Functional significance of miRNA was first de...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-016-0316-1
更新日期:2016-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Novel therapies for damaged and diseased bone are being developed in a preclinical testing process consisting of in vitro cell experiments followed by in vivo animal studies. The in vitro results are often not representative of the results observed in vivo. This could be caused by the complexity of th...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-020-00649-5
更新日期:2021-01-11 00:00:00
abstract::Surrogate markers in clinical medicine provide a useful means to assess therapeutic response to pharmacologic therapy in a wide range of chronic disease states. In the area of osteoporosis, the surrogate markers of change in bone mineral density (BMD) and bone turnover markers (BTM) provide the clinician with a means ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-005-0018-6
更新日期:2005-09-01 00:00:00
abstract::The postmenopausal state is the most common underlying cause for osteoporosis and most of our understanding of the condition relates to this group. Recent evidence has suggested that hormone therapy may no longer have the pre-eminent place it once held but the same studies have also confirmed its antifracture efficacy...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-004-0018-y
更新日期:2004-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Authors review the safety and efficacy of romosozumab for the treatment of osteoporosis as demonstrated in three phase III clinical trials and offer insights into the potential cardiovascular risk associated with its use. RECENT FINDINGS:Incidence of new vertebral fracture is dramatically reduced wit...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-020-00652-w
更新日期:2021-01-07 00:00:00
abstract::Osteoporosis in men is an unrecognized but growing problem as the number of men who live to old age increases. The 10-year fracture risk at age 50 quadruples by age 80, and in general the incidence rate of osteoporotic fracture in men is about half that of women. Of note, the mortality and morbidity after hip fracture...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-996-0030-5
更新日期:2006-09-01 00:00:00
abstract::Based on spiral 3D tomography a large variety of applications have been developed during the last decade to asses bone mineral density, bone macro and micro structure, and bone strength. Quantitative computed tomography (QCT) using clinical whole body scanners provides separate assessment of trabecular, cortical, and ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-013-0147-2
更新日期:2013-09-01 00:00:00
abstract::The pediatric origin of osteoporosis has led many investigators to focus on determining factors that influence bone gain during growth and methods for optimizing this gain. Bone responds to bone loading activities by increasing mass or size. Overall, pediatric studies have found a positive effect of bone loading on bo...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-013-0152-5
更新日期:2013-09-01 00:00:00
abstract::Metabolic bone disease is a major public health concern, especially when it manifests as hip fracture which carries significant morbidity and mortality. Individuals with neurological disease are at higher risk of osteopenia, osteoporosis and fragility fracture compared to age-matched controls, yet this is under-apprec...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-016-0320-5
更新日期:2016-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs). RECENT FINDINGS:The results show that the physical and chemical properties of the nanomaterials are suitable f...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-018-0476-2
更新日期:2018-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This review critiques the ability of CT-based methods to predict incident hip and vertebral fractures. RECENT FINDINGS:CT-based techniques with concurrent calibration all show strong associations with incident hip and vertebral fracture, predicting hip and vertebral fractures as well as, and sometime...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-018-0450-z
更新日期:2018-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Identifying individuals at high fracture risk can be used to target those likely to derive the greatest benefit from treatment. This narrative review examines recent developments in using specific risk factors used to assess fracture risk, with a focus on publications in the last 3 years. RECENT FIND...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-020-00590-7
更新日期:2020-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The goal of this paper is to review state-of-the-art transcriptome profiling methods and their recent applications in the field of skeletal biology. RECENT FINDINGS:Next-generation sequencing of mRNA (RNA-seq) methods have been established and routinely used in skeletal biology research. RNA-seq has ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-019-00517-x
更新日期:2019-08-01 00:00:00
abstract::Statistical models (SMs) of shape (SSM) and appearance (SAM) have been acquiring popularity in medical image analysis since they were introduced in the early 1990s. They have been primarily used for segmentation, but they are also a powerful tool for 3D reconstruction and classification. All these tasks may be require...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-014-0206-3
更新日期:2014-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Osteocytes comprise > 95% of the cellular component in bone tissue and produce a wide range of cytokines and cellular signaling molecules in response to mechanical stimuli. In this review, we aimed to summarize the molecular mechanisms involved in the osteocyte-mediated translation of mechanical stimu...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-020-00564-9
更新日期:2020-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL), and has emerged as an important novel therapy for skeletal disorders. This article examines the use of denosumab in children. RECENT FINDINGS:Considerable safety and efficacy data exists for denosumab treatment ...
journal_title:Current osteoporosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11914-017-0380-1
更新日期:2017-08-01 00:00:00