Abstract：
:Bone metastasis is a deadly complication of cancers arising from many different primary tumor locations. Cross talk between cancer and bone cells is a well-established driver of bone metastasis, and recent work reveals microRNA (miRNA) as key players in this communication. Functional significance of miRNA was first demonstrated in cancer cells and has now also been documented in bone cell differentiation and skeletal remodeling. Review of recent literature highlights how different miRNAs can impact each step of the metastatic process by acting in both tumor and the metastatic niche to exert pleiotropic effects. Additionally, whether a miRNA is ultimately pro- or anti-metastatic dependents on the context-varied or even opposite outcomes can be conferred by the same miRNA in different cancer/cell types. In spite of this complexity, emerging research has provided a wealth of knowledge to uncover the exciting potential of miRNA as new diagnostic tools and therapeutic treatments for cancer bone metastasis.
journal_name
Curr Osteoporos Repjournal_title
Current osteoporosis reportsauthors
Baier SR,Wan Ydoi
10.1007/s11914-016-0316-1subject
Has Abstractpub_date
2016-10-01 00:00:00pages
163-9issue
5eissn
1544-1873issn
1544-2241pii
10.1007/s11914-016-0316-1journal_volume
14pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:This paper describes recent advances in understanding the mechanisms that drive fracture pain and how these findings are helping develop new therapies to treat fracture pain. RECENT FINDINGS:Immediately following fracture, mechanosensitive nerve fibers that innervate bone are mechanically distorted. ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-018-0446-8
更新日期：2018-08-01 00:00:00
abstract：:The occurrence of a fragility fracture is an opportunity to recognize osteoporosis and begin treatment to reduce the risk of another fracture. However, selecting the treatment may have an impact on the incident fracture and this requires careful consideration of the patient and the treatment choices. There is no conse...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-011-0061-4
更新日期：2011-09-01 00:00:00
abstract：:The greatest cause of preventable morbidity and mortality is smoking, and one of the often-underappreciated effects of smoking is profound bone loss. The existing clinical paradigm for smoking is that there is a low turnover osteoporosis. This review highlights findings from recent clinical trials and animal research ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-011-0068-x
更新日期：2011-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Identifying individuals at high fracture risk can be used to target those likely to derive the greatest benefit from treatment. This narrative review examines recent developments in using specific risk factors used to assess fracture risk, with a focus on publications in the last 3 years. RECENT FIND...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00590-7
更新日期：2020-06-01 00:00:00
abstract：:Osteoporosis is characterized by the occurrence of a host of fractures. According to densitometric values, an operational definition for osteoporosis corresponds to a loss of 25% to 30% (-2.5 T-scores) compared with the mean values of bone mineral density of young premenopausal women. For years, research tried to deve...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-010-0024-1
更新日期：2010-09-01 00:00:00
abstract：:A prior fracture is a well-documented risk factor for a subsequent fracture and it doubles the risk of subsequent fractures. Few studies have investigated the time that elapses between the initial and subsequent fracture. These studies show that the subsequent fracture risk is not constant, but fluctuates over time. T...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-010-0023-2
更新日期：2010-09-01 00:00:00
abstract：:Stem cells differ from other cells of the body in their potential for multilineage differentiation and their continued proliferation without substantial loss of potential (so-called self-renewal). These properties are maintained and regulated by a specific microenvironment referred to as "niche." This term has been us...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-011-0075-y
更新日期：2011-12-01 00:00:00
abstract：:Low vitamin D status, which is endemic due to inadequate oral intake combined with sun avoidance, contributes to musculoskeletal and other pathologies. Although controversial, it is increasingly recommended that serum 25-hydroxyvitamin D (25D) concentrations less than 30 ng/mL be considered suboptimal. Clinicians shou...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-008-0017-5
更新日期：2008-09-01 00:00:00
abstract：:The musculoskeletal system is a complex organ comprised of the skeletal bones, skeletal muscles, tendons, ligaments, cartilage, joints, and other connective tissue that physically and mechanically interact to provide animals and humans with the essential ability of locomotion. This mechanical interaction is undoubtedl...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0209-0
更新日期：2014-06-01 00:00:00
abstract：:Understanding of osteoclast formation and activation has advanced considerably since the discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem cells express receptor activator of NF-jB ligand (RANKL), which binds to its receptor, RANK, on the surface of osteoclasts and their precursors....
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-007-0024-y
更新日期：2007-09-01 00:00:00
abstract：PURPOSE OF REVIEW:The goal of the review is to summarize the current knowledge on the process of chondrocyte-to-osteoblast transdifferentiation during endochondral bone formation and its potential implications in fracture healing and disease. RECENT FINDINGS:Lineage tracing experiments confirmed the transdifferentiati...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00511-3
更新日期：2019-06-01 00:00:00
abstract：:Statistical models (SMs) of shape (SSM) and appearance (SAM) have been acquiring popularity in medical image analysis since they were introduced in the early 1990s. They have been primarily used for segmentation, but they are also a powerful tool for 3D reconstruction and classification. All these tasks may be require...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-014-0206-3
更新日期：2014-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Mechanical loading is an essential stimulus for skeletal tissues. Osteocytes are primarily responsible for sensing mechanical stimuli in bone and for orchestrating subsequent responses. This is critical for maintaining homeostasis, and responding to injury/disease. The osteocyte mechanotransduction pa...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-018-0485-1
更新日期：2018-12-01 00:00:00
abstract：:Atraumatic fractures of the skeleton in osteoporotic patients are directly related to a deterioration of bone strength. However, the failure of the bone tissue to withstand functional load bearing cannot be explained as a simple decrease in bone mineral density (quantity); strength is also significantly dependent upon...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-003-0003-x
更新日期：2003-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Neurogenic heterotopic ossification (NHO) is the abnormal formation of extra-skeletal bones in periarticular muscles after damage to the central nervous system (CNS) such as spinal cord injury (SCI), traumatic brain injury (TBI), stroke, or cerebral anoxia. The purpose of this review is to summarize r...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00636-w
更新日期：2020-12-01 00:00:00
abstract：:Intercellular communication within the bone microenvironment is critical for the maintenance of normal bone structure. Osteoblast-lineage cells at all stages of differentiation, from pluripotent precursors to matrix-embedded osteocytes, produce regulatory factors that modulate the differentiation and activity of both ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-012-0096-1
更新日期：2012-06-01 00:00:00
abstract：:Surrogate markers in clinical medicine provide a useful means to assess therapeutic response to pharmacologic therapy in a wide range of chronic disease states. In the area of osteoporosis, the surrogate markers of change in bone mineral density (BMD) and bone turnover markers (BTM) provide the clinician with a means ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-005-0018-6
更新日期：2005-09-01 00:00:00
abstract：PURPOSE OF REVIEW:This review outlines the recent findings regarding the impact of bariatric surgery on bone. It explores potential mechanisms for skeletal changes following bariatric surgery and strategies for management. RECENT FINDINGS:Bone loss following bariatric surgery is multifactorial. Probable mechanisms inc...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00579-2
更新日期：2020-06-01 00:00:00
abstract：:As the population with HIV continues to age, specialists in HIV care are increasingly encountering chronic health conditions, which now include osteoporosis, osteopenia, and fragility fractures. The pathophysiology of the bone effects of HIV infection is complex and includes traditional risk factors for bone loss as w...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-012-0125-0
更新日期：2012-12-01 00:00:00
abstract：:The postmenopausal state is the most common underlying cause for osteoporosis and most of our understanding of the condition relates to this group. Recent evidence has suggested that hormone therapy may no longer have the pre-eminent place it once held but the same studies have also confirmed its antifracture efficacy...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-004-0018-y
更新日期：2004-09-01 00:00:00
abstract：:Vitamin D, acting through its active metabolite 1,25(OH)(2)D(3), exerts its influence on many physiologic processes in addition to the regulation of calcium and phosphate homeostasis. These processes include the immune system. Both the adaptive and innate immune systems are affected by 1,25(OH)(2)D(3) and its receptor...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-009-0011-6
更新日期：2009-07-01 00:00:00
abstract：:Osteoporosis presents a dilemma for the orthopedic surgeon. Screw fixation within the bone is crucial for mechanical stabilization, maintenance of reduction, and ultimately, fracture healing. For the patient, soft bones and physiological fragility usually benefit from immediate weight bearing and mobility to avoid fur...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-012-0124-1
更新日期：2012-12-01 00:00:00
abstract：PURPOSE OF REVIEW:To summarize reports published since the 2013 American Society of Bone and Mineral Research Task Force Report on atypical femoral fractures (AFF). RECENT FINDINGS:The absolute incidence of AFFs remains low. AFFs are primarily associated with prolonged bisphosphonate (BP) exposure, but have also been ...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-018-0464-6
更新日期：2018-08-01 00:00:00
abstract：:Currently, the measurement of areal bone mineral density (aBMD) is used at NASA to evaluate the effects of spaceflight on the skeletal health of astronauts. Notably, there are precipitous declines in aBMD with losses >10 % detected in the hip and spine in some astronauts following a typical 6-month mission in space. H...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-013-0136-5
更新日期：2013-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Diabetes has a detrimental effect on bone, increasing the risk of fracture and formation of osteolytic lesions such as those seen in periodontitis. Several diabetic complications are caused by diabetes-enhanced inflammation. This review examines mechanisms by which IL-17 contributes to diabetes-enhanc...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00559-6
更新日期：2020-02-01 00:00:00
abstract：PURPOSE OF REVIEW:One aim in bone tissue engineering is to develop human cell-based, 3D in vitro bone models to study bone physiology and pathology. Due to the heterogeneity of cells among patients, patient's own cells are needed to be obtained, ideally, from one single cell source. This review attempts to identify the...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00648-6
更新日期：2021-01-15 00:00:00
abstract：PURPOSE OF REVIEW:Here, we overview the latest findings from studies investigating the skeletal endocannabinoid (EC) system and its involvement in bone formation and resorption. RECENT FINDINGS:The endocannabinoid system consists of endogenous ligands, receptors, and enzymes. The main cannabinoids found in the cannabi...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-020-00607-1
更新日期：2020-10-01 00:00:00
abstract：:Microbial biofilms have been observed and described in bone specimens of patients with bisphosphonate (BP)-associated osteonecrosis of the jaw (BONJ) and investigators are more recently suggesting that this condition essentially represents an osteomyelitis of the jaw clinically, with greater susceptibility in some pat...
journal_title：Current osteoporosis reports
pub_type： 杂志文章
doi：10.1007/s11914-010-0008-1
更新日期：2010-03-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to explore the role of monocyte chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone remodelling, particularly the action of osteoblasts and osteoclasts, and its role in the development and metastasis of cancers that target the bone. RECENT FINDI...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-019-00545-7
更新日期：2019-12-01 00:00:00
abstract：:Osteoporotic fractures result in significant morbidity and mortality. Anabolic agents reverse the negative skeletal balance that characterizes osteoporosis by stimulating osteoblast-dependent bone formation to a greater degree than osteoclast-dependent bone resorption. Parathyroid hormone (PTH) and parathyroid hormone...
journal_title：Current osteoporosis reports
pub_type： 杂志文章,评审
doi：10.1007/s11914-013-0171-2
更新日期：2013-12-01 00:00:00
