Abstract:
:Androgens are essential for the development, differentiation, growth, and function of the prostate through epithelial-stromal interactions. However, androgen concentrations in the hypertrophic human prostate decrease significantly with age, suggesting an inverse correlation between androgen levels and proliferative diseases of the aging prostate. In elderly males, age- and/or androgen-related stromal remodeling is spontaneously induced, i.e., increased fibroblast and myofibroblast numbers, but decreased smooth muscle cell numbers in the prostatic stroma. These fibroblasts produce not only growth factors, cytokines, and extracellular matrix proteins, but also microRNAs as stromal paracrine signals that stimulate prostate epithelial cell proliferation. Surgical or chemical castration is the standard systemic therapy for patients with advanced prostate cancer. Androgen deprivation therapy induces temporary remission, but the majority of patients eventually progress to castration-resistant prostate cancer, which is associated with a high mortality rate. Androgen deprivation therapy-induced stromal remodeling may be involved in the development and progression of castration-resistant prostate cancer. In the tumor microenvironment, activated fibroblasts stimulating prostate cancer cell proliferation are called carcinoma-associated fibroblasts. In this review, we summarize the role of stromal paracrine signals in proliferative diseases of the aging human prostate and discuss the potential clinical applications of carcinoma-associated fibroblast-derived exosomal microRNAs as promising biomarkers.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Ishii K,Takahashi S,Sugimura Y,Watanabe Mdoi
10.3390/jcm7040068subject
Has Abstractpub_date
2018-04-02 00:00:00issue
4issn
2077-0383pii
jcm7040068journal_volume
7pub_type
杂志文章,评审abstract:BACKGROUND:Research findings regarding the association between tricyclic antidepressant (TCA) treatment and the risk of fracture are not consistent; we aimed to assess whether people who take TCAs are at an increased fracture risk. METHODS:Relevant studies published through June 2020 were identified through database s...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9082584
更新日期:2020-08-10 00:00:00
abstract::We aimed to report an update of the systematic review by Petrén et al. (2003). The objective was to evaluate how orthodontic treatments can affect unilateral posterior crossbite (UPXB) in primary and early mixed dentition. Several databases were consulted, and articles published between January 2002 and March 2020 wer...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10010033
更新日期:2020-12-24 00:00:00
abstract::The aim of the study was to evaluate the effect of titanium bone fixations on mitochondrial activity, reactive oxygen species (ROS) production, glutathione metabolism, and selected markers of oxidative/nitrosative stress in the periosteum-like tissue of patients treated with mandible fractures. The study group consist...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8010127
更新日期:2019-01-21 00:00:00
abstract::We aimed to test the association between low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD), cancer, and all-cause mortality in non-statin users. A total of 347,971 subjects in Kangbuk Samsung Health Study (KSHS.57.4% men, mean follow up: 5.64 ± 3.27 years) were tested. To validate these asso...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101571
更新日期:2019-10-01 00:00:00
abstract::Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate collectively commonly as small clusters. Such collectively migrating cancer...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8050725
更新日期:2019-05-22 00:00:00
abstract:OBJECTIVE:To review the current published literature on the use of procalcitonin as a diagnostic and prognostic marker in adult patients with meningitis. METHODS:We conducted a PubMed search to identify all relevant publications regarding the diagnostic and prognostic value of serum procalcitonin in patients with a kn...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7060148
更新日期:2018-06-11 00:00:00
abstract::Sleep bruxism (SB) is a masticatory muscle activity during sleep that is characterized as rhythmic (phasic) or non-rhythmic (tonic). The recent hypothesis on the etiology of SB supports the role of the central and autonomic nervous systems. Therefore, in this study, we aimed to assess the intensity of SB in patients w...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7100327
更新日期:2018-10-05 00:00:00
abstract::The authors wish to make the following corrections to this paper [...]. ...
journal_title:Journal of clinical medicine
pub_type: 已发布勘误
doi:10.3390/jcm9020569
更新日期:2020-02-19 00:00:00
abstract::The integrated assessment of nutritional status and presence of sarcopenia would help improve clinical outcomes of in-hospital aged patients. We compared three common nutritional screening tools with the new Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria among hospitalized older patients. To t...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061898
更新日期:2020-06-17 00:00:00
abstract::Orf virus (OV) is a zoonotic parapoxvirus that causes highly proliferative skin lesions which resolve with minimal inflammation and scarring. OV encodes two immunomodulators, vascular endothelial growth factor (VEGF)-E and interleukin-10 (ovIL-10), which individually modulate skin repair and inflammation. This study e...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041085
更新日期:2020-04-11 00:00:00
abstract::Hyperglycemia is a common occurrence in hospitalized patients receiving parenteral and/or enteral nutrition. Although there are several approaches to manage hyperglycemia, there is no consensus on the best practice. We systematically searched PubMed, Embase, Cochrane Central, and ClinicalTrials.gov to identify records...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8070935
更新日期:2019-06-28 00:00:00
abstract:BACKGROUND:The National Academies of Science have issued a call for zero preventable trauma deaths. The mortality characteristics in all patients with aortic injury are not well described. METHODS:All prehospital and hospital medical examiner records for deaths occurring in Harris County, Texas in 2014 were retrospect...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092965
更新日期:2020-09-14 00:00:00
abstract::The prognosis of multiple myeloma (MM) has improved with the introduction of novel agents. These data are largely derived from clinical trials and might not reflect real-world patient outcomes accurately. We surveyed real-world data from 284 patients newly diagnosed with MM between 2010 and 2018 in Miyazaki Prefecture...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10010105
更新日期:2020-12-30 00:00:00
abstract::With the improvement in survival rate, cardiotoxicity has emerged as a significant adverse effect of cancer therapy. Early diagnosis of subclinical cardiac injury may allow the initiation of cardioprotective therapy and preventing the interruption of optimal cancer therapy and the development of irreversible cardiac d...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10010154
更新日期:2021-01-05 00:00:00
abstract::COVID-19 has catastrophically affected the world's panoramic view of human well-being in terms of healthcare and management. With the increase in the number of cases worldwide, neurological symptoms and psychological illnesses from COVID-19 have increasingly upsurged. Mental health illness and affective disorders, inc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9082624
更新日期:2020-08-13 00:00:00
abstract::Molecular monitoring of minimal residual disease (MRD) and BCR-ABL1 kinase domain (KD) mutation testing have a well consolidated role in the routine management of chronic myeloid leukemia (CML) patients, as they provide precious information for therapeutic decision-making. Molecular response levels are used to define ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9123865
更新日期:2020-11-27 00:00:00
abstract::(1) Background: This study evaluated the perioperative red blood cell (RBC) transfusion need and determined predictors for transfusion in patients undergoing elective primary lumbar posterior spine fusion in a high-volume center for spine surgery. (2) Methods: Data from all patients undergoing spine surgery between 1 ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7020019
更新日期:2018-01-30 00:00:00
abstract::Histological evaluation of renal biopsies is currently the gold standard for acquiring important diagnostic and prognostic information in diabetic nephropathy (DN) patients. Nevertheless, there is an unmet clinical need for new biomarkers that allow earlier diagnosis and risk stratification. As biochemical changes in ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8071022
更新日期:2019-07-12 00:00:00
abstract::The number of healthy and frail older adults is increasing worldwide, especially in industrialized countries, as a result of the increase in life expectancy [...]. ...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm10020166
更新日期:2021-01-06 00:00:00
abstract::The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051503
更新日期:2020-05-16 00:00:00
abstract::Central serous chorioretinopathy (CSC) is a complex and not entirely understood retinal disease. The aim of our research was to describe a novel optical coherence tomography (OCT) finding named "choroidal rift", which may be identified in the choroid of eyes with CSC. We collected data from 357 patients (488 eyes) wit...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072260
更新日期:2020-07-16 00:00:00
abstract::Both pre-gestational maternal obesity (PGMO) and excessive gestational weight gain (EGWG) increase the risk of gestational diabetes mellitus (GDM). Here, we conducted a retrospective study to comparatively examine the relation between fetal birth weight (FW) and placental weight (PW) in PGMO (n = 100) compared to EGWG...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113530
更新日期:2020-10-31 00:00:00
abstract::The World Health Organization (WHO) considers quality of life a fundamental indicator. The effect of birth on women's long-term quality of life (QoL) has barely been studied. The purpose of this study was to determine the factors related with the pregnancy, delivery and puerperium, and assess women's QoL after giving ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8030324
更新日期:2019-03-07 00:00:00
abstract::Although skin manifestations are quite common in systemic sclerosis (SSc), a link between SSc and psoriasis (PsO) has been poorly investigated. We assessed the Clalit medical database in a cohort study to compare the prevalence of PsO between SSc-patients and SSc-free controls. We also evaluated the SSc-related autoan...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040521
更新日期:2019-04-16 00:00:00
abstract::Pain in Sickle Cell Disease (SCD) is a major comorbidity and unique with acute pain due to recurrent and episodic vaso-occlusive crises as well as chronic pain, which can span an individual's entire life. Opioids are the mainstay treatment for pain in SCD. Due to recent health crises raised by adverse effects includin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9123902
更新日期:2020-12-01 00:00:00
abstract::Two doses of propiverine ER (30 and 45 mg/d) are available for the treatment of overactive bladder (OAB) syndrome. We have explored factors associated with the initial dosing choice (allocation bias), the decision to adapt dosing (escalation bias) and how dosing relative to other factors affects treatment outcomes. Da...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020311
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:As much as there are unmet needs for brief frailty assessment in patients with chronic obstructive pulmonary disease (COPD), the lack of a simplified and comprehensive dyspnea evaluation system that focuses on the patients' perceptions of dyspnea and their COPD living disabilities remains a major challenge. ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113580
更新日期:2020-11-06 00:00:00
abstract::The widespread epidemic of obesity and type 2 diabetes (T2D), suggests that both disorders are closely linked. Several pre-clinical and clinical studies have showed that adipose-derived mesenchymal stem cells (ASC) transplantation is efficient and safe. Moreover, scientists have already highlighted the therapeutic cap...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060765
更新日期:2019-05-30 00:00:00
abstract::FOLFIRINOX (FX) and gemcitabine (GEM) plus nab-paclitaxel (GnP) have been reported as effective regimens for unresectable advanced pancreatic cancer (APC). FX may be more effective but is also associated with more adverse events (AEs). Therefore, first-line treatment with FX followed by second-line GnP may be appropri...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060761
更新日期:2019-05-29 00:00:00
abstract::Endometriosis concerns more than 10% of women of reproductive age, frequently leading to chronic pelvic pain. Repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) induces an analgesic effect. This effect on chronic pelvic pain is yet to be evaluated. The objective of this study was to...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040508
更新日期:2019-04-13 00:00:00