Abstract:
:The prognosis of multiple myeloma (MM) has improved with the introduction of novel agents. These data are largely derived from clinical trials and might not reflect real-world patient outcomes accurately. We surveyed real-world data from 284 patients newly diagnosed with MM between 2010 and 2018 in Miyazaki Prefecture. The median follow-up period was 32.8 months. The median age at diagnosis was 71 years, with 68% of patients aged >65 years. The International Staging System (ISS) stage at diagnosis was I in 18.4% of patients, II in 34.1%, and III in 47.5%. Bortezomib-containing regimens were preferred as initial treatment; they were used in 147 patients (51.8%). In total, 80% of patients were treated with one or more novel agents (thalidomide, lenalidomide, or bortezomib). Among 228 patients who were treated with novel agents as an initial treatment, the overall response rate (partial response (PR) or better) to initial treatment was 78.4%, and the median time to next treatment (TTNT) was 11.6 months. In the multivariate analysis, PR or better responses to initial treatment were independently favorable prognostic factors for TTNT. The median survival time after initial therapy for patients with novel agents was 56.4 months and 3-year overall survival (OS) was 70.4%. In multivariate analysis, ISS stage I/II disease and PR or better response to initial treatment, and autologous stem cell transplantation (ASCT) were identified as independent prognostic factors for overall survival (OS).
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Akizuki K,Matsuoka H,Toyama T,Kamiunten A,Sekine M,Shide K,Kameda T,Kawano N,Maeda K,Takeuchi M,Kawano H,Sato S,Ishizaki J,Tahira Y,Shimoda H,Hidaka T,Yamashita K,Kubuki Y,Shimoda Kdoi
10.3390/jcm10010105subject
Has Abstractpub_date
2020-12-30 00:00:00issue
1issn
2077-0383pii
jcm10010105journal_volume
10pub_type
杂志文章abstract::Although skin manifestations are quite common in systemic sclerosis (SSc), a link between SSc and psoriasis (PsO) has been poorly investigated. We assessed the Clalit medical database in a cohort study to compare the prevalence of PsO between SSc-patients and SSc-free controls. We also evaluated the SSc-related autoan...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040521
更新日期:2019-04-16 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is a common condition, affecting 5⁻10% of women of reproductive age worldwide. It has serious reproductive implications and causes mood disorders and metabolic disorders, such as type-2 diabetes. Because PCOS reflects multiple abnormalities, there is no single drug that can treat all i...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7070179
更新日期:2018-07-22 00:00:00
abstract::Microbial contamination could compromise the stability of dental implants increasing the risk of inflammatory reactions in the surrounding soft tissues. In this human, randomized, double-blind, clinical study, the presence of Porphyromonas gingivalis on the healing abutment and the inflammatory infiltrate surrounding ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010284
更新日期:2020-01-20 00:00:00
abstract::Fertility preservation in trans women is a crucial but thus far neglected component in the gender confirming treatment in Germany. It is difficult for trans women to access reproductive health care because centers offering treatment, psychological guidance, gender confirming surgery, as well as reproductive health ser...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8050730
更新日期:2019-05-22 00:00:00
abstract:BACKGROUND:Invasive fungal disease (IFD) is common in solid organ transplant (SOT) recipients and contributes to high morbidity and mortality. Although kidney transplantation (KT) is a commonly performed SOT, data on the risk factors for IFD-related mortality are limited. METHODS:A 1:2 retrospective case-control study...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061824
更新日期:2020-06-11 00:00:00
abstract::Proteins have been demonstrated to reduce food intake in animals and humans via peripheral and central mechanisms. Supplementation of a dietetic regimen with single or mixed amino acids might represent an approach to improve the effectiveness of any body weight reduction program in obese subjects. The aim of the prese...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9093054
更新日期:2020-09-22 00:00:00
abstract::One in every four deaths is due to cancer in Europe. In view of its increasing incidence, cancer became the leading cause of death and disease burden in Denmark, France, the Netherlands, and the UK. Without essential improvements in cancer prevention, an additional 775,000 cases of annual incidence have been prognosed...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092749
更新日期:2020-08-25 00:00:00
abstract::There is increasing data in favour of follicle-stimulating hormone (FSH) therapy in patients with oligo-asthenozoospermia and normal-range gonadotropins in order to increase sperm count and above all sperm motility. Some studies showed an improvement in DNA fragmentation and spontaneous pregnancy. Recently, biosimilar...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051478
更新日期:2020-05-14 00:00:00
abstract::Pulmonary vein (PV) enlargement is associated with atrial fibrillation (AF). However, the predictive value of PV volume for new-onset AF has not been determined. We retrospectively assessed and enrolled non-AF subjects who underwent echocardiography and cardiac CT angiography (CCTA) around the same time and evaluated ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020401
更新日期:2020-02-02 00:00:00
abstract:BACKGROUND:It has been recommended that any invasive treatment performed in patients with central serous chorioretinopathy (CSCR) not be initiated earlier than four months after disease onset due to the potential for spontaneous remission of symptoms. The goal of this study was to examine the outcome of transfoveal sub...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091398
更新日期:2019-09-06 00:00:00
abstract::To investigate the clinicopathological features and treatment outcomes in patients with stage I, high-risk endometrial cancer. Patients with International Federation of Gynecology and Obstetrics stage I, papillary serous, clear cell, or grade 3 endometrioid carcinoma treated between 2000 and 2012 were analyzed for the...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7090254
更新日期:2018-09-04 00:00:00
abstract::Coronavirus disease 2019 (COVID-19), due to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become an epidemiological threat and a worldwide concern. SARS-CoV-2 has spread to 210 countries worldwide and more than 6,500,000 confirmed cases and 384,643 deaths have been reported, while the number of...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9061753
更新日期:2020-06-05 00:00:00
abstract::T-cell-depleted (TCD) human leukocyte antigen (HLA) haploidentical (haplo) hematopoietic stem cell transplantation (HSCT) (TCD-haplo-HSCT) has had a huge impact on the treatment of many haematological diseases. The adoptive transfer of a titrated number of T cells genetically modified with a gene suicide can improve i...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111904
更新日期:2019-11-07 00:00:00
abstract:BACKGROUND:Cesarean deliveries represent a large percentage of deliveries worldwide. Patients undergoing repeat cesarean deliveries are known to have increased risks for surgical complications. However, little is known regarding potential differences in pain. We sought to compare postoperative opioid consumption and pa...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122221
更新日期:2019-12-16 00:00:00
abstract::Contemporary minimally invasive surgical (MIS) treatment options of patients with male Lower Urinary Tract Symptoms (LUTS) in men with prostate glands >80 mL include Holmium Laser Enucleation Prostate (HoLEP), Thulium laser VapoEnucleation Prostate (ThuVEP), and Laparoscopic (LSP) or Robotic-Assisted Simple Prostatect...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9061798
更新日期:2020-06-09 00:00:00
abstract:BACKGROUND:Bioelectrical impedance analysis (BIA) is a simple and rapid technique to measure body composition (BC). Validity of BIA in patients with low body mass index (BMI) remains controversial. We assessed the validity of several BIA equations to evaluate fat-free mass (FFM), fat mass (FM) and muscle mass in patien...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113664
更新日期:2020-11-14 00:00:00
abstract::The radial nerve is the most frequently injured nerve in the upper extremity. Numerous options in treatment have been described for radial nerve injury, such as neurolysis, nerve grafts, or tendon transfers. Currently, new treatment options are arising, such as platelet-rich plasma (PRP), an autologous product with pr...
journal_title:Journal of clinical medicine
pub_type:
doi:10.3390/jcm7020013
更新日期:2018-01-29 00:00:00
abstract::Paragangliomas and pheochromytomas (PPGLs) exhibit variable malignancy, advanced/hormonally active/progressive need therapy. PRRT (Peptide Receptor Radionuclide Therapy) could be an option for these patients. To evaluate the effectiveness of PRRT (90Y DOTATATE), based on overall survival (OS) and progression-free surv...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8070952
更新日期:2019-06-30 00:00:00
abstract::Long noncoding RNAs (lncRNAs) are involved in diverse physiological and pathological processes by modulating gene expression. They have been found to be dysregulated in the brain and cerebrospinal fluid of patients with neurodegenerative diseases, and are considered promising therapeutic targets for treatment. Among t...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7110461
更新日期:2018-11-21 00:00:00
abstract::Paravalvular leak (PVL) is an important complication of transcatheter aortic valve implantation (TAVI) and is associated with poor prognosis. We aimed to identify the risk factors for PVL after TAVI including patient (calcium amount or location), device (leakage-proof or not), and procedural (oversizing index (OI)) fa...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123936
更新日期:2020-12-04 00:00:00
abstract:BACKGROUND:The National Academies of Science have issued a call for zero preventable trauma deaths. The mortality characteristics in all patients with aortic injury are not well described. METHODS:All prehospital and hospital medical examiner records for deaths occurring in Harris County, Texas in 2014 were retrospect...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092965
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:Both old age and institutionalization in aged care homes come with a significant risk of developing several long-term mental and neurological disorders, but there has been no definitive meta-analysis of data from studies to determine the pooled estimate of central nervous system (CNS) medicines use in aged c...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091292
更新日期:2019-08-23 00:00:00
abstract::Conventional angiography is used to evaluate and treat possible sources of intraabdominal bleeding, though it may cause complications such as contrast-induced nephropathy (CIN). The study's purpose was to identify factors predicting active extravasation and complications during angiography for acute intraabdominal ble...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm6040047
更新日期:2017-04-18 00:00:00
abstract::Limited information on the effect of antiretroviral treatment (ART) on vascular function in South Africans of African descent living with human immunodeficiency virus (HIV) is available. The relationship between ART, vascular function and cardiovascular risk factors in South Africans of African ancestry with HIV was t...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10030392
更新日期:2021-01-20 00:00:00
abstract:INTRODUCTION:Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated disease characterised pathologically by the infiltration of IgG4-bearing plasma cells into the involved organs. Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis with a heavy lymphocytic infiltration and two distinct hi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020409
更新日期:2020-02-03 00:00:00
abstract::Social media enables the public sharing of information. With the recent emphasis on transparency and the open sharing of information between doctors and patients, the intersection of social media and healthcare is of particular interest. Twitter is currently the most popular form of social media used for healthcare co...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7060121
更新日期:2018-05-28 00:00:00
abstract::Minimally invasive surgery is becoming popular for treating spinal disorders. The advantages of percutaneous endoscopic debridement and drainage (PEDD) for infectious spondylitis include direct observation of the lesion, direct pus drainage, and earlier pain relief. We retrospectively reviewed 37 patients who underwen...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091356
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:In order to promote physical activity (PA) in patients with complicated type 2 diabetes, a better understanding of daily movement is required. We (1) objectively assessed PA in patients with type 2 diabetes, and (2) studied the association between muscle mass, dietary protein intake, and PA. Methods: We perfo...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103104
更新日期:2020-09-25 00:00:00
abstract::It is now widely established that management of lung cancer is much more complex and cannot be centered on the binary classification of small-cell versus non-small cell lung cancer (NSCLC). Lung cancer is now recognized as a highly heterogeneous disease that develops from genetic mutations and gene expression patterns...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7060153
更新日期:2018-06-15 00:00:00
abstract::An increasing number of patients with coronary artery disease are at high operative risk due to advanced age, severe comorbidities, complex coronary anatomy, and reduced ejection fraction. Consequently, these high-risk patients are often offered percutaneous coronary intervention (PCI) as an alternative to coronary ar...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113414
更新日期:2020-10-25 00:00:00