Abstract：
:An increasing number of patients with coronary artery disease are at high operative risk due to advanced age, severe comorbidities, complex coronary anatomy, and reduced ejection fraction. Consequently, these high-risk patients are often offered percutaneous coronary intervention (PCI) as an alternative to coronary artery bypass grafting (CABG). We aimed to investigate the outcome of patients with diabetes mellitus (DM) undergoing high-risk PCI. We analyzed consecutive patients undergoing high-risk PCI (period 01/2016-08/2018). In-hospital major adverse cardiac and cerebrovascular events (MACCEs), defined as in-hospital stroke, myocardial infarction and death, and the one-year incidence of death from any cause were assessed in patients with and without DM. There were 276 patients (age 70 years, 74% male) who underwent high-risk PCI. Eighty-six patients (31%) presented with DM (insulin-dependent DM: n = 24; non-insulin-dependent DM: n = 62). In-hospital MACCEs occurred in 9 patients (3%) with a non-significant higher rate in patients with DM (n = 5/86, 6% vs. n = 4/190 2%; p = 0.24). In patients without DM, the survival rate was insignificantly higher than in patients with DM (93.6% vs. 87.1%; p = 0.07). One-year survival was not significantly different in DM patients with more complex coronary artery disease (SYNTAX I-score ≤ 22: 89.3% vs. > 22: 84.5%; p = 0.51). In selected high-risk patients undergoing high-risk PCI, DM was not associated with an increased incidence of in-hospital MACCEs or a decreased one-year survival rate.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Johannsen L,Soldat J,Krueger A,Mahabadi AA,Dykun I,Totzeck M,Jánosi RA,Rassaf T,Al-Rashid Fdoi
10.3390/jcm9113414subject
Has Abstractpub_date
2020-10-25 00:00:00issue
11issn
2077-0383pii
jcm9113414journal_volume
9pub_type
杂志文章abstract：:This study sought to determine whether the implementation of regular and structured follow-up of patients with chronic heart failure (CHF), combined with therapeutic education and remote monitoring solution, leads to better management. This was a single-center retrospective study conducted in a cohort of patients with...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103106
更新日期：2020-09-25 00:00:00
abstract：BACKGROUND AND AIMS:The markers of renal damage defining subclinical AKI are not widely used in children undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). The aim of the study was to evaluate serum and urinary clusterin as indices of kidney injury after alloHSCT in relation to damage (kidney inj...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082599
更新日期：2020-08-11 00:00:00
abstract：:: Several researchers have assessed the utility of Impulse Oscillometry System (IOS) in diagnosing and evaluating the severity of respiratory diseases in childhood, but none has investigated the impact of the fluctuations of IOS parameters in an individualized manner. In this two-year prospective study, we aimed to lo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091475
更新日期：2019-09-16 00:00:00
abstract：:There is increasing data in favour of follicle-stimulating hormone (FSH) therapy in patients with oligo-asthenozoospermia and normal-range gonadotropins in order to increase sperm count and above all sperm motility. Some studies showed an improvement in DNA fragmentation and spontaneous pregnancy. Recently, biosimilar...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051478
更新日期：2020-05-14 00:00:00
abstract：:Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors. In this ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8060757
更新日期：2019-05-28 00:00:00
abstract：:The aim of this paper was to provide insights into alcohol misuse within UK veterans to inform as to whether their presentations differ from the general public. This was done by exploring differences in the severity of alcohol misuse between UK veterans and the general public admitted to a general NHS hospital over an...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm5110095
更新日期：2016-11-02 00:00:00
abstract：:Despite the overall success of cochlear implantation, language outcomes remain suboptimal and subject to large inter-individual variability. Early auditory rehabilitation techniques have mostly focused on low-level sensory abilities. However, a new body of literature suggests that cognitive operations are critical for...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041058
更新日期：2020-04-08 00:00:00
abstract：:Maternal and pediatric delivery outcomes may vary in patients who underwent open fetal myelomeningocele repair and elected to deliver at the fetal center where their fetal intervention was performed versus at the referring physician's hospital. A prospective cohort study of 88 patients were evaluated following in uter...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113443
更新日期：2020-10-27 00:00:00
abstract：:With the expanded legalization of marijuana, its medical and recreational use have sharply increased over the past decade. A wide array of new forms of cannabis is available on the market today, and the potencies are ten times those of forms previously tested, meaning that the true impact of marijuana on the cardiovas...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061925
更新日期：2020-06-19 00:00:00
abstract：:The non-consensual sharing of an intimate image is a serious breach of a person's right to privacy and can lead to severe psychosocial consequences. However, little research has been conducted on the reasons for consuming intimate pictures that have been shared non-consensually. This study aims to investigate how the ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050706
更新日期：2019-05-17 00:00:00
abstract：:Guidelines for the treatment of severe bleeding comprise viscoelastic-test-guided use of coagulation factor concentrates as part of their recommendations. The aim of this study is to investigate the effects of substituting fibrinogen, prothrombin complex concentrate, and a combination of both on conventional coagulati...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123805
更新日期：2020-11-25 00:00:00
abstract：:Continuous renal replacement therapy (CRRT) is an important modality to support critically ill patients, and the need for CRRT treatment has been increasing. However, CRRT management is costly, and the associated resources are limited. Thus, it remains challenging to identify patients that are likely to have a poor ou...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7100334
更新日期：2018-10-08 00:00:00
abstract：INTRODUCTION:Telemedicine is believed to be helpful in managing patients suffering from chronic diseases, in particular elderly patients with numerous accompanying conditions. This was the basis for the "GERIATRICS and e-Technology (GER-e-TEC) study", which was an experiment involving the use of the smart MyPredi™ e-pl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123836
更新日期：2020-11-26 00:00:00
abstract：:ApoCIII and triglyceride (TG)-rich lipoproteins (TRL), particularly, large TG-rich lipoproteins particles, have been described as important mediators of cardiovascular disease (CVD) risk. The effects of sustained consumption of dietary fructose compared with those of sustained glucose consumption on circulating apoCII...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8070913
更新日期：2019-06-26 00:00:00
abstract：:Conventional 3D multicellular tumor spheroids of head and neck squamous cell carcinoma (HNSCC) consisting exclusively of cancer cells have some limitations. They are compact cell aggregates that do not interact with their extracellular milieu, thus suffering from both insufficient extracellular matrix (ECM) deposition...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101686
更新日期：2019-10-15 00:00:00
abstract：:The investigation of the potential association between ischemic stroke and subclinical atrial fibrillation (SCAF) is important for secondary prevention. We aimed to determine whether SCAF can be predicted by atrial substrate measurement with P wave signal-averaged electrocardiography (SAECG). We recruited 125 consecut...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041134
更新日期：2020-04-15 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) facilitates neuronal growth and plasticity, and is crucial for learning and memory. Contactin-1 (CNTN1) is a member of the subfamily of neural immunoglobulin and is involved in the formation of axon connections in the developing nervous system. This cross-sectional study invest...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091366
更新日期：2019-09-02 00:00:00
abstract：BACKGROUND:Wolf-Hirschhorn syndrome (WHS) is a rare disease caused by deletion in the distal moiety of the short arm of chromosome 4. The objectives of this study were to report the most representative oral findings of WHS, relate them with other clinical characteristics of the disease, and establish possible phenotype...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113556
更新日期：2020-11-04 00:00:00
abstract：:Acute myeloid leukemia is mainly characterized by a complex and dynamic genomic instability. Next-generation sequencing has significantly improved the ability of diagnostic research to molecularly characterize and stratify patients. This detailed outcome allowed the discovery of new therapeutic targets and predictive ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9030802
更新日期：2020-03-16 00:00:00
abstract：:Diabetes mellitus is one of the most prevalent chronic diseases worldwide. Diabetic patients are at risk of developing cataract and present for surgery at an earlier age than non-diabetics. The aim of this study was to review the problems associated with cataract surgery in a diabetic patient. Corneal complications in...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8050716
更新日期：2019-05-20 00:00:00
abstract：:Substantial progress in recent years has dramatically increased our knowledge of the molecular basis of cancer, revealing new potential therapeutic targets and paving the way for effective personalised medicine for the treatment of many tumour types. However, pancreatic cancer has been lagging behind in this success a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10010149
更新日期：2021-01-04 00:00:00
abstract：:* Correspondence: kasiajanda@op [...]. ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061652
更新日期：2020-05-31 00:00:00
abstract：:Since the discovery of the causal association between human papillomavirus (HPV) and cervical cancer, efforts to develop an effective prophylactic vaccine to prevent high-risk HPV infections have been at the forefront of modern medical research. HPV causes 530,000 cervical cancer cases worldwide, which is the second m...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm4040614
更新日期：2015-04-03 00:00:00
abstract：:Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors, are now known to b...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8101669
更新日期：2019-10-12 00:00:00
abstract：PURPOSE:To investigate the value of visual acuity and patient-perceived visual function test when subretinal drusenoid deposits (SDD) are incorporated into the classification of age-related macular degeneration (AMD). A total of 50 participants were recruited into the study in these groups: healthy ageing (n = 11), int...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092832
更新日期：2020-09-01 00:00:00
abstract：:Air pollution is a major environmental risk to health and a global public health concern. In 2016, according to the World Health Organization (WHO), ambient air pollution in cities and rural areas was estimated to cause 4.2 million premature deaths. It is estimated that around 91% of the world's population lives in pl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10010077
更新日期：2020-12-28 00:00:00
abstract：:Limited information on the effect of antiretroviral treatment (ART) on vascular function in South Africans of African descent living with human immunodeficiency virus (HIV) is available. The relationship between ART, vascular function and cardiovascular risk factors in South Africans of African ancestry with HIV was t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10030392
更新日期：2021-01-20 00:00:00
abstract：BACKGROUND:For acute adnexal torsion of pregnant women, appropriate treatment based on an accurate diagnosis is especially important for fertility preservation and timely treatment. The 2017 American College of Obstetricians and Gynecologists (ACOG) Committee Opinion No. 723 announced its practice-changing guidelines t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072209
更新日期：2020-07-13 00:00:00
abstract：:Arteriogenesis supplies oxygen and nutrients in the tumor microenvironment (TME), which may play an important role in tumor growth and metastasis. Pancreatic neuroendocrine tumors (pNETs) are the second most common pancreatic malignancy and are frequently metastatic on presentation. Nearly a third of pNETs secrete bio...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111980
更新日期：2019-11-14 00:00:00
abstract：:The UBE3A gene codes for a protein with two known functions, a ubiquitin E3-ligase which catalyzes ubiquitin binding to substrate proteins and a steroid hormone receptor coactivator. UBE3A is most famous for its critical role in neuronal functioning. Lack of UBE3A protein expression leads to Angelman syndrome (AS), wh...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051573
更新日期：2020-05-22 00:00:00
