Abstract：
:ApoCIII and triglyceride (TG)-rich lipoproteins (TRL), particularly, large TG-rich lipoproteins particles, have been described as important mediators of cardiovascular disease (CVD) risk. The effects of sustained consumption of dietary fructose compared with those of sustained glucose consumption on circulating apoCIII and large TRL particles have not been reported. We measured apoCIII concentrations and the TG and cholesterol content of lipoprotein subfractions separated by size in fasting and postprandial plasma collected from men and women (age: 54 ± 8 years) before and after they consumed glucose- or fructose-sweetened beverages for 10 weeks. The subjects consuming fructose exhibited higher fasting and postprandial plasma apoCIII concentrations than the subjects consuming glucose (p < 0.05 for both). They also had higher concentrations of postprandial TG in all TRL subfractions (p < 0.05, effect of sugar), with the highest increases occurring in the largest TRL particles (p < 0.0001 for fructose linear trend). Compared to glucose consumption, fructose consumption increased postprandial TG in low-density lipoprotein (LDL) particles (p < 0.05, effect of sugar), especially in the smaller particles (p < 0.0001 for fructose linear trend). The increases of both postprandial apoCIII and TG in large TRL subfractions were associated with fructose-induced increases of fasting cholesterol in the smaller LDL particles. In conclusion, 10 weeks of fructose consumption increased the circulating apoCIII and postprandial concentrations of large TRL particles compared with glucose consumption.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Hieronimus B,Griffen SC,Keim NL,Bremer AA,Berglund L,Nakajima K,Havel PJ,Stanhope KLdoi
10.3390/jcm8070913subject
Has Abstractpub_date
2019-06-26 00:00:00issue
7issn
2077-0383pii
jcm8070913journal_volume
8pub_type
杂志文章abstract：:Exercise has health benefits and prevents a range of chronic diseases caused by physiological and biological changes in the whole body. Generally, the metabolic regulation of skeletal muscle through exercise is known to have a protective effect on the pathogenesis of metabolic syndrome, non-alcoholic fatty liver disea...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2021-01-20 00:00:00
abstract：BACKGROUND:Congenital factor (F) VII deficiency is a rare coagulation factor deficiency with an estimated incidence of 1 per 500,000 individuals. Patients with severe FVII deficiency present a broad range of clinical presentations. Alloimmunization against exogenous FVII, as the main challenge of replacement therapy, i...
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abstract：BACKGROUND:The long-term stability after soft tissue graft for covering gingival recession remains a pivotal goal for both patient and periodontist. Therefore, the aim of this study was to compare the four-year outcomes of the coronally advanced flap (CAF) versus the pouch/tunnel (POT) technique, both combined with con...
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journal_title：Journal of clinical medicine
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更新日期：2018-03-13 00:00:00
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更新日期：2020-04-22 00:00:00
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更新日期：2020-02-14 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-10-31 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2019-05-22 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2021-01-14 00:00:00
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pub_type： 杂志文章,评审
doi：10.3390/jcm9041030
更新日期：2020-04-06 00:00:00
abstract：:To investigate the clinicopathological features and treatment outcomes in patients with stage I, high-risk endometrial cancer. Patients with International Federation of Gynecology and Obstetrics stage I, papillary serous, clear cell, or grade 3 endometrioid carcinoma treated between 2000 and 2012 were analyzed for the...
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pub_type： 杂志文章
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更新日期：2018-09-04 00:00:00
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更新日期：2018-08-02 00:00:00
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更新日期：2019-11-01 00:00:00
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更新日期：2019-01-07 00:00:00
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