Abstract:
:The worldwide epidemiology of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), still shows an increasing trend in Asia and Iran. Despite an improvement in the treatment landscape focused on symptomatic control, long-term colectomies have not decreased over the last 10-year period. Thus, novel therapies are urgently needed in clinics to supplement the existing treatments. Mesenchymal stem cells (MSCs) are multipotent adult stem cells with immunosuppressive effects, targeting IBD as a new treatment strategy. They have recently received global attention for their use in cell transplantation due to their easy expansion and wide range of activities to be engrafted, and because they are home to the mucosa of the intestine. Moreover, MSCs are able to differentiate into epithelial and other cells that can directly promote repair in the mucosal damages in UC. It seems that there is a need to deepen our understanding to target MSCs as a promising treatment option for UC patients who are refractory to conventional therapies. Here, we overviewed the therapeutic effects of MSCs in UC and discussed the achievements and challenges in the cell transplantation of UC.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Hosseini-Asl SK,Mehrabani D,Karimi-Busheri Fdoi
10.3390/jcm9123922subject
Has Abstractpub_date
2020-12-03 00:00:00issue
12issn
2077-0383pii
jcm9123922journal_volume
9pub_type
杂志文章,评审abstract::The purpose of this study is to describe the Minimally Invasive Intraoral Approach (MIIA) performed on selected cases of abscesses and neck phlegmons of odontogenic origin when the infection has not spread beyond the inferior mandibular margin. This technique allows us to avoid cervicotomy by a direct approach to the ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092971
更新日期:2020-09-14 00:00:00
abstract::After normal survival has been achieved in most patients with chronic myeloid leukemia (CML), a new goal for treating CML is survival at good quality of life, with treatment discontinuation in sustained deep molecular response (DMR; MR4 or deeper) and treatment-free remission (TFR). Four tyrosine kinase inhibitors (TK...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9113671
更新日期:2020-11-16 00:00:00
abstract:BACKGROUND:To compare the clinical, serological and histologic features between male and female patients with Sjögren's syndrome (SS) and explore the potential effect of gender on lymphoma development. METHODS:From a multicenter population (Universities of Udine, Pisa and Athens, Harokopion and Ioannina (UPAHI)) consi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082620
更新日期:2020-08-12 00:00:00
abstract::Background: There is emerging evidence that radiographic progression-free survival (rPFS) is highly correlated with overall survival (OS), potentially serving as an indicator of treatment outcome for castration-resistant prostate cancer (CRPC). The objective of this study is to assess rPFS and prostate specific antige...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8081251
更新日期:2019-08-19 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDA) is notorious for its poor prognosis. The current mainstay of treatment for PDA is surgical resection followed by adjuvant chemotherapy. However, it is difficult to predict the post-operative outcome because of the lack of reliable markers. The single-nucleotide polymorphism (SNP)...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122225
更新日期:2019-12-16 00:00:00
abstract::(1) Background: Endoscopic management of hilar biliary obstruction is still challenging. Compared with unilateral drainage, bilateral drainage could preserve larger functional liver volume and potentially improve clinical outcomes. To evaluate the effectiveness of bilateral drainage, we conducted this multicenter rand...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020206
更新日期:2021-01-08 00:00:00
abstract::In the grey zone of testosterone levels between 8 and 12 nmol/L, the usefulness of therapy is controversial; as such, markers of tissue action of androgens may be helpful in adjusting clinical decisions. To better understand the effect of the hypothalamic-pituitary-testicular axis on male accessory secretion, we perfo...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122128
更新日期:2019-12-03 00:00:00
abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19), first emerged in Wuhan, China. The clinical manifestations of patients infected with COVID-19 include fever, cough, and dyspnea, up to acute respiratory distress syndrome (ARDS) and acute cardiac inju...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9124057
更新日期:2020-12-15 00:00:00
abstract::Tadalafil 5 mg represents the standard for men with Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS)/benign prostatic enlargement (BPE). We carried out an observational trial aiming to assess the efficacy and safety of Tadalafil compared with Tadalafil plus Tamsulosin. Seventy-five patients complainin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8081126
更新日期:2019-07-29 00:00:00
abstract::Atherosclerosis is a progressive, inflammatory cardiovascular disorder characterized by the development of lipid-filled plaques within arteries. Endothelial cell dysfunction in the walls of blood vessels results in an increase in vascular permeability, alteration of the components of the extracellular matrix, and rete...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8111856
更新日期:2019-11-02 00:00:00
abstract:BACKGROUND:There is growing evidence that non-alcoholic fatty liver disease (NAFLD) is a disease affecting not only the liver but also extrahepatic organs. AIM:To investigate whether in youths NAFLD is associated with extrahepatic complications such as subclinical atherosclerosis, cardiac abnormalities, hypertension, ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8060868
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:Current therapeutic options in the course of metastatic castration-resistant prostate cancers (mCRPC) reinforce the need for reliable tools to characterize the tumor in a dynamic way. Circulating tumor cells (CTCs) have emerged as a viable solution to the problem, whereby patients with a variety of solid tum...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072066
更新日期:2020-07-01 00:00:00
abstract::Actinic cheilitis (AC) is one of the most frequent pathologies to affect the lips. Studies show that the most commonplace oral malignancy, squamous cell carcinoma (SCC), often emerges from AC lesions. Invasive diagnostic techniques performed on the lips carry a high risk of complications, but reflectance confocal micr...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061987
更新日期:2020-06-25 00:00:00
abstract:BACKGROUND:Cefazolin is in vitro active against wild isolates of Escherichia coli, Klebsiella species, and Proteus mirabilis (EKP), but clinical evidence supporting the contemporary susceptibility breakpoint issued by the Clinical and Laboratory Standards Institute (CLSI) are limited. METHODS:Between 2010 and 2015, ad...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010157
更新日期:2020-01-07 00:00:00
abstract::Ocular surgery is one of the most performed medical procedures in the world. Its limitation or suspension, recursively extended over time, could be associated with a significant increase in the number of blind people worldwide. Indeed, cataract causes more than half of all cases of visual impairment in those countries...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm9051403
更新日期:2020-05-09 00:00:00
abstract:BACKGROUND:Daily management to shield chronic dialysis patients from SARS-CoV-2 contamination makes patient care cumbersome. There are no screening methods to date and a molecular biology platform is essential to perform RT-PCR for SARS-CoV-2; however, accessibility remains poor. Our goal was to assess whether the tool...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10010004
更新日期:2020-12-22 00:00:00
abstract::Preterm infants are at higher risk for both symmetrical and asymmetrical head molding. This study involved 3D stereophotogrammetry to assess the cranial growth, molding, and incidence of deformational plagiocephaly (DP) in preterm children compared to term born children. Thirty-four preterm infants and 34 term born co...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101665
更新日期:2019-10-11 00:00:00
abstract::The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in efforts to identify therapies to ameliorate adverse clinical outcomes. The recognition of the key role for increased inflammation in COVID-19 has led to a proliferation of clinical trials targeting inflammation. The purpose of this review is to c...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092935
更新日期:2020-09-11 00:00:00
abstract:BACKGROUND:The direct oral anticoagulant rivaroxaban inhibiting specifically activated factor X (FXa) causes delayed thrombin generation (TG) as measured by calibrated automated thrombography (CAT). The implications of these changes for assessing bleeding or residual prothrombotic risks of patients are unclear in the a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111990
更新日期:2019-11-15 00:00:00
abstract::Bronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly seen in premature infants who required mechanical ventilation and oxygen therapy for acute respiratory distress. While advances in neonatal care have resulted in improved survival rates of premature infants, limited progress has been made in redu...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm6010004
更新日期:2017-01-06 00:00:00
abstract::The main risk factor for primary open-angle glaucoma (POAG) is increased intraocular pressure (IOP). It is of interest that about half of the patients have an IOP within the normal range (normal-tension glaucoma, NTG). Additionally, there is a group of patients with a high IOP but no glaucomatous neurodegeneration (oc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092979
更新日期:2020-09-15 00:00:00
abstract::Androgen/androgen receptor (AR) signaling is a significant driver of prostate cancer progression, therefore androgen-deprivation therapy (ADT) is often used as a standard form of treatment for advanced and metastatic prostate cancer patients. However, after several years of ADT, prostate cancer progresses to castratio...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8030354
更新日期:2019-03-13 00:00:00
abstract::MicroRNAs (miRNAs) can provide insight into the pathophysiological states of ocular tissues such as proliferative diabetic retinopathy (PDR). In this study, differences in miRNA expression in vitreous from PDR patients with and without incidence of recurrent vitreous hemorrhage (RVH) after the initial pars-plana vitre...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122217
更新日期:2019-12-15 00:00:00
abstract::This study aimed to understand whether the effect of non-metastatic cells 1 (NME1) on recurrence-free survival (RFS) in early stage non-small cell lung cancer (NSCLC) can be modified by β-catenin overexpression and cisplatin-based adjuvant chemotherapy. Expression levels of NME1 and β-catenin were analyzed using immun...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103067
更新日期:2020-09-23 00:00:00
abstract:OBJECTIVE:To investigate the risk and risk factors for suicide attempt by patients with regular migraines (RM) and status migrainosus (SM) in Taiwan. METHODS:We analyzed a subset of the National Health Insurance Research Database of Taiwan and enrolled patients (≥20 years old) who had ever received a diagnosis of RM o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7090269
更新日期:2018-09-11 00:00:00
abstract::Post-transplant diabetes mellitus (PTDM) is a serious complication in renal transplant recipients. Branched-chain amino acids (BCAAs) are involved in the pathogenesis of insulin resistance. We determined the association of plasma BCAAs with PTDM and included adult renal transplant recipients (≥18 y) with a functioning...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020511
更新日期:2020-02-13 00:00:00
abstract::A higher incidence rate of nocturia in patients with obstructive sleep apnea (OSA) has been observed. We investigated the differences in clinical examinations between OSA patients with and without nocturia, and further compared those with successful and unsuccessful uvulopalatopharyngoplasty (UPPP). This retrospective...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103089
更新日期:2020-09-25 00:00:00
abstract::Periodontal ligament-derived mesenchymal stem cells (hPDLSCs) possess immunomodulatory abilities which are strongly enhanced by various inflammatory cytokines. Vitamin D3 has anti-inflammatory effects on hPDLSCs and immune cells. However, no study to date has directly compared the influence of 1,25(OH)2D3 on the immun...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122211
更新日期:2019-12-14 00:00:00
abstract::The identification of biomarkers predicting disease severity and outcomes is the focus of intense research in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection). Ideally, such biomarkers should be easily derivable from routine tests. We conducted a systematic review and meta-analysis ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020286
更新日期:2021-01-14 00:00:00
abstract::There are no reliable, non-invasive methods to accurately measure cardiac output (CO) in septic patients. MostCare (Vytech Health™, Vygon, Padova, Italy), is a beat-to-beat, self calibrated method for CO measurement based on continuous analysis of reflected arterial pressure waveforms. We enrolled 40 patients that wer...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020213
更新日期:2021-01-09 00:00:00