当前位置： SCI文献检索 > Journal of Clinical Medicine期刊下所有文献 > Comparison of Radiographic Progression-Free Survival and PSA Response on Sequential Treatment Using Abiraterone and Enzalutamide for Newly Diagnosed Castration-Resistant Prostate Cancer: A Propensity Score Matched Analysis from Multicenter Cohort.

Comparison of Radiographic Progression-Free Survival and PSA Response on Sequential Treatment Using Abiraterone and Enzalutamide for Newly Diagnosed Castration-Resistant Prostate Cancer: A Propensity Score Matched Analysis from Multicenter Cohort.

Abstract：

:Background: There is emerging evidence that radiographic progression-free survival (rPFS) is highly correlated with overall survival (OS), potentially serving as an indicator of treatment outcome for castration-resistant prostate cancer (CRPC). The objective of this study is to assess rPFS and prostate specific antigen (PSA) response in sequential treatment using androgen signaling inhibitors (ASIs) including abiraterone and enzalutamide in newly diagnosed CRPC. Methods: Propensity score matching was performed to reduce bias by confounding factors between first-line ASIs. The primary endpoints of the study included rPFS, time to PSA progression (TTPP), and PSA response. Results: A paired-matched group of 184 patients were identified. From the initiation of first-line ASIs, there was no significant difference in rPFS, TTPP, and PSA response between treatment arms. From the initiation of second-line ASIs, enzalutamide following abiraterone consistently exhibited longer rPFS (median: 7 and 15 months, p = 0.04), TTPP, and better PSA response compared to the reverse, whereas OS did not reach significance (median: 14 and 23 months, p = 0.35). Conclusion: Although the effect of ASIs as the first line was similar, the extent of cross-resistance might differ towards less resistance in enzalutamide following abiraterone than the reverse.

journal_name

J Clin Med

journal_title

Journal of clinical medicine

authors

Komura K,Fujiwara Y,Uchimoto T,Saito K,Tanda N,Matsunaga T,Ichihashi A,Tsutsumi T,Tsujino T,Yoshikawa Y,Nishimoto Y,Takai T,Minami K,Taniguchi K,Tanaka T,Uehara H,Hirano H,Nomi H,Ibuki N,Takahara K,Inamoto T,Azu

doi

10.3390/jcm8081251

subject

Has Abstract

pub_date

2019-08-19 00:00:00

issue

8

issn

2077-0383

pii

jcm8081251

journal_volume

8

pub_type

杂志文章

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