Abstract：
:Exercise has health benefits and prevents a range of chronic diseases caused by physiological and biological changes in the whole body. Generally, the metabolic regulation of skeletal muscle through exercise is known to have a protective effect on the pathogenesis of metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), and cardiovascular disease (CVD). Besides this, the importance of the liver as an endocrine organ is a hot research topic. Hepatocytes also secrete many hepatokines in response to nutritional conditions and/or physical activity. In particular, certain hepatokines play a major role in the regulation of whole-body metabolic homeostasis. In this review, we summarize the recent research findings on the exercise-mediated regulation of hepatokines, including fibroblast growth factor 21, fetuin-A, angiopoietin-like protein 4, and follistatin. These hepatokines serve as molecular transducers of the metabolic benefits of physical activity in chronic metabolic diseases, including NAFLD, T2D, and CVDs, in various tissues.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Seo DY,Park SH,Marquez J,Kwak HB,Kim TN,Bae JH,Koh JH,Han Jdoi
10.3390/jcm10030385subject
Has Abstractpub_date
2021-01-20 00:00:00issue
3issn
2077-0383pii
jcm10030385journal_volume
10pub_type
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