Abstract：
:Bruton's tyrosine kinase (BTK) is a critical terminal enzyme in the B-cell antigen receptor (BCR) pathway. BTK activation has been implicated in the pathogenesis of certain B-cell malignancies. Targeting this pathway has emerged as a novel target in B-cell malignancies, of which ibrutinib is the first-in-class agent. A few other BTK inhibitors (BTKi) are also under development (e.g., acalabrutinib). While the predominant action of BTKi is the blockade of B-cell receptor pathway within malignant B-cells, increasing the knowledge of off-target effects as well as a potential role for B-cells in proliferation of solid malignancies is expanding the indication of BTKi into non-hematological malignancies. In addition to the expansion of the role of BTKi monotherapy, combination therapy strategies utilizing ibrutinib with established regimens and combination with modern immunotherapy compounds are being explored.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Campbell R,Chong G,Hawkes EAdoi
10.3390/jcm7040062subject
Has Abstractpub_date
2018-03-21 00:00:00issue
4issn
2077-0383pii
jcm7040062journal_volume
7pub_type
杂志文章,评审abstract：:(1) Background: This study evaluated the perioperative red blood cell (RBC) transfusion need and determined predictors for transfusion in patients undergoing elective primary lumbar posterior spine fusion in a high-volume center for spine surgery. (2) Methods: Data from all patients undergoing spine surgery between 1 ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7020019
更新日期：2018-01-30 00:00:00
abstract：:Bronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly seen in premature infants who required mechanical ventilation and oxygen therapy for acute respiratory distress. While advances in neonatal care have resulted in improved survival rates of premature infants, limited progress has been made in redu...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2017-01-06 00:00:00
abstract：:Aim. To evaluate by meta-analysis of interventional studies the effect of statin therapy on arterial wall inflammation. Background. Arterial exposure to low-density lipoprotein (LDL) cholesterol levels is responsible for initiation and progression of atherosclerosis and arterial wall inflammation. 18F-fluorodeoxygluco...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2019-01-18 00:00:00
abstract：:Long noncoding RNAs (lncRNAs) are involved in diverse physiological and pathological processes by modulating gene expression. They have been found to be dysregulated in the brain and cerebrospinal fluid of patients with neurodegenerative diseases, and are considered promising therapeutic targets for treatment. Among t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7110461
更新日期：2018-11-21 00:00:00
abstract：:This study aimed to understand whether the effect of non-metastatic cells 1 (NME1) on recurrence-free survival (RFS) in early stage non-small cell lung cancer (NSCLC) can be modified by β-catenin overexpression and cisplatin-based adjuvant chemotherapy. Expression levels of NME1 and β-catenin were analyzed using immun...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-09-23 00:00:00
abstract：:Since the discovery of the causal association between human papillomavirus (HPV) and cervical cancer, efforts to develop an effective prophylactic vaccine to prevent high-risk HPV infections have been at the forefront of modern medical research. HPV causes 530,000 cervical cancer cases worldwide, which is the second m...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm4040614
更新日期：2015-04-03 00:00:00
abstract：BACKGROUND:Anemia of Chronic Disease (ACD) can negatively influence the clinical course of Inflammatory Bowel Disease (IBD) patients. The aim of this study was to evaluate the effect of Vedolizumab on ACD in IBD. METHODS:Clinical data of 75 IBD patients (25 Crohn's disease (CD) and 50 Ulcerative Colitis (UC)) receivin...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-07-06 00:00:00
abstract：BACKGROUND:Pembrolizumab is an immune checkpoint inhibitor against programmed cell death protein-1 (PD-1) approved for therapy in metastatic melanoma. PD-1 expression is associated with a diminished functionality in HIV-1 specific-CD8+ T cells. It is thought that PD-1 blockade could contribute to reinvigorate antiviral...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122089
更新日期：2019-12-01 00:00:00
abstract：:The non-consensual sharing of an intimate image is a serious breach of a person's right to privacy and can lead to severe psychosocial consequences. However, little research has been conducted on the reasons for consuming intimate pictures that have been shared non-consensually. This study aims to investigate how the ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050706
更新日期：2019-05-17 00:00:00
abstract：BACKGROUND:No dural substitute has proven to be complication-free in a large clinical trial, even suggesting some benefit during watertight closure. However, primary dural closure is not always possible due to dural shrinkage from electrocautery for dural bleeding. OBJECTIVE:This study is performed to analyze the clin...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9040902
更新日期：2020-03-25 00:00:00
abstract：:Postoperative atrial fibrillation (POAF) is linked with increased morbidity, mortality rate and financial liability. About 20-50% of patients experience POAF after coronary artery bypass graft (CABG) surgery. Numerous review articles and meta-analyses have investigated links between patient clinical risk factors, demo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9041139
更新日期：2020-04-16 00:00:00
abstract：:Air composition influences Dry Eye (DE) symptoms as demonstrated by studies that have linked the outdoor environment to DE. However, there is insufficient data on the effect of short-term exposure to indoor environments on DE symptoms. We conducted a prospective experimental research, in which an older building served...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051316
更新日期：2020-05-02 00:00:00
abstract：:A key criterion for the most common chronic liver disease-non-alcoholic fatty liver disease (NAFLD)-is an intrahepatic fat content above 5% in individuals who are not using steatogenic agents or having significant alcohol intake. Subjects with NAFLD have increased plasma concentrations of glucagon, and emerging eviden...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9124049
更新日期：2020-12-15 00:00:00
abstract：:The burden of cardiovascular disease and death in chronic kidney disease (CKD) outpaces that of the other diseases and is not adequately described by traditional risk factors alone. Diminished activity of paraoxonase (PON)-1 is associated with increased oxidant stress, a common feature underlying the pathogenesis of C...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071034
更新日期：2019-07-15 00:00:00
abstract：:Background: Due to the higher frequency of ischemic stroke in men compared to women, we aimed to determine if gender differences exist regarding periodontal status and several plasma biomarkers in patients with a recent large artery atherosclerosis ischemic stroke (IS). Material and methods: Patients with their first ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061744
更新日期：2020-06-04 00:00:00
abstract：:Pediatric cancer survivors are at increased risk for psychological distress. We sought to understand the severity and symptoms' co-occurrence among pediatric survivors compared to controls by rating both self- and parent-reported symptomatology. Forty survivors (22 males; mean age at study time: 12.9 years) participat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113444
更新日期：2020-10-27 00:00:00
abstract：:Epileptic seizures in critically ill patients represent a major source of concern, because they are associated with significant mortality and morbidity rates. Despite recent advances that have enabled a better understanding of the global epidemiology of this entity, epileptic seizures in critically ill patients remain...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm9072218
更新日期：2020-07-13 00:00:00
abstract：:Ongoing outbreak of pneumonia caused by novel coronavirus (2019-nCoV) began in December 2019 in Wuhan, China, and the number of new patients continues to increase. Even though it began to spread to many other parts of the world, such as other Asian countries, the Americas, Europe, and the Middle East, the impact of se...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9040944
更新日期：2020-03-30 00:00:00
abstract：:Radiation chorioretinopathy, radiation maculopathy, and radiation optic neuropathy are the major complications of ophthalmic radiotherapy. Optical coherence tomography (OCT) and OCT angiography (OCTA) are revolutionary imaging methods, allowing the visualization of the retinal cellular architecture and the retinal vas...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9113496
更新日期：2020-10-29 00:00:00
abstract：:Staphylococcus aureus bloodstream infection (SA-BSI) is an infection with increasing morbidity and mortality. Concomitant Staphylococcus aureus bacteriuria (SABU) frequently occurs in patients with SA-BSI. It is considered as either a sign of exacerbation of SA-BSI or a primary source in terms of urosepsis. The clinic...
journal_title：Journal of clinical medicine
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abstract：:The application of biomarkers in medicine is evolving. Biomarkers do not only give us a better understanding of pathogenesis, but also increase treatment efficacy and safety, further enabling more precise clinical care. This paper focuses on the current use of biomarkers in atopic dermatitis, new developments and futu...
journal_title：Journal of clinical medicine
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更新日期：2015-03-16 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2018-05-10 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2020-06-06 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2019-08-19 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2020-01-25 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-06-25 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2018-04-02 00:00:00
abstract：:Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in older populations in industrialized nations. AMD is a late-onset deterioration of photoreceptors and retinal pigment epithelium in the central retina caused by various environmental and genetic factors. Great strides i...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm4020343
更新日期：2015-02-12 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2020-05-30 00:00:00
abstract：BACKGROUND:The clinical outcome of patients affected by dilated cardiomyopathy (DCM) is heterogeneous, since its pathophysiology is only partially understood. Interleukin 1β levels could predict the mortality and necessity of cardiac transplantation of DCM patients. OBJECTIVE:To investigate mechanisms triggering steri...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-09-21 00:00:00
